Matches in SemOpenAlex for { <https://semopenalex.org/work/W3209324861> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W3209324861 abstract "Background: Malaria is a parasitic infection that is common in the tropical and sub-tropical regions of the world. It is estimated to kill one million individuals annually. Detarium microcarpum (Fabaceae family) is used traditionally for the treatment of malaria, diabetes, hypertension, convulsions, pneumonia, leprosy, and meningitis. The purpose of this research was to evaluate the antiplasmodial potential and safety profile of the methanol extract of D. microcarpum stem bark. Methods: The extract was subjected to phytochemical screening and oral median lethal dose (LD50) estimation. Using curative, suppressive, and prophylactic experimental animal models, antiplasmodial activity was assessed in mice infected with chloroquine-sensitive Plasmodium berghei berghei. Biochemical and hematological tests were conducted in rats orally administered with the extract for 28 days. One-way analysis of variance (ANOVA) was used to analyze the data, followed by Dunnett's post hoc test. Results: Alkaloids, flavonoids, saponins, tannins, triterpenes, and glycosides were found in the extract through phytochemical analysis. When compared to the negative control group, the extract at the tested doses (200, 400, and 800 mg/kg) showed a significant (P < 0.001) curative, suppressive, and prophylactic effect and significantly (P < 0.001) prolonged the survival time of mice in the treated groups. The extract had an insignificant (P > 0.05) effect on the biochemical and hematological parameters tested. Conclusion: The results suggest that the stem bark extract of D. microcarpum at the doses tested possesses antiplasmodial activity and is relatively safe after short-term use." @default.
- W3209324861 created "2021-11-08" @default.
- W3209324861 creator A5002890895 @default.
- W3209324861 creator A5020492764 @default.
- W3209324861 creator A5081996255 @default.
- W3209324861 date "2021-10-27" @default.
- W3209324861 modified "2023-10-14" @default.
- W3209324861 title "In Vivo Antiplasmodial Activity of Detarium microcarpum (Fabaceae) Stem Bark Extract" @default.
- W3209324861 cites W1506043065 @default.
- W3209324861 cites W1956981268 @default.
- W3209324861 cites W1978567215 @default.
- W3209324861 cites W1985647431 @default.
- W3209324861 cites W1987774572 @default.
- W3209324861 cites W1993999400 @default.
- W3209324861 cites W2015221460 @default.
- W3209324861 cites W2017806914 @default.
- W3209324861 cites W2018420490 @default.
- W3209324861 cites W2020392184 @default.
- W3209324861 cites W2033721665 @default.
- W3209324861 cites W2042464457 @default.
- W3209324861 cites W2043301708 @default.
- W3209324861 cites W2064931301 @default.
- W3209324861 cites W2091129884 @default.
- W3209324861 cites W2099544645 @default.
- W3209324861 cites W2103478791 @default.
- W3209324861 cites W2103508330 @default.
- W3209324861 cites W2122849872 @default.
- W3209324861 cites W2126748724 @default.
- W3209324861 cites W2138034858 @default.
- W3209324861 cites W2138909719 @default.
- W3209324861 cites W2157409604 @default.
- W3209324861 cites W2159942149 @default.
- W3209324861 cites W2163006457 @default.
- W3209324861 cites W2163440018 @default.
- W3209324861 cites W2169431889 @default.
- W3209324861 cites W2206011794 @default.
- W3209324861 cites W2263023695 @default.
- W3209324861 cites W2496250482 @default.
- W3209324861 cites W2756286840 @default.
- W3209324861 cites W2993175395 @default.
- W3209324861 cites W4211234055 @default.
- W3209324861 cites W4233775358 @default.
- W3209324861 doi "https://doi.org/10.5812/thrita.116921" @default.
- W3209324861 hasPublicationYear "2021" @default.
- W3209324861 type Work @default.
- W3209324861 sameAs 3209324861 @default.
- W3209324861 citedByCount "2" @default.
- W3209324861 countsByYear W32093248612022 @default.
- W3209324861 crossrefType "journal-article" @default.
- W3209324861 hasAuthorship W3209324861A5002890895 @default.
- W3209324861 hasAuthorship W3209324861A5020492764 @default.
- W3209324861 hasAuthorship W3209324861A5081996255 @default.
- W3209324861 hasBestOaLocation W32093248611 @default.
- W3209324861 hasConcept C126322002 @default.
- W3209324861 hasConcept C167552308 @default.
- W3209324861 hasConcept C194671627 @default.
- W3209324861 hasConcept C195475562 @default.
- W3209324861 hasConcept C203014093 @default.
- W3209324861 hasConcept C2777237215 @default.
- W3209324861 hasConcept C2778048844 @default.
- W3209324861 hasConcept C2780900450 @default.
- W3209324861 hasConcept C29730261 @default.
- W3209324861 hasConcept C556039675 @default.
- W3209324861 hasConcept C59822182 @default.
- W3209324861 hasConcept C71924100 @default.
- W3209324861 hasConcept C86803240 @default.
- W3209324861 hasConcept C98274493 @default.
- W3209324861 hasConceptScore W3209324861C126322002 @default.
- W3209324861 hasConceptScore W3209324861C167552308 @default.
- W3209324861 hasConceptScore W3209324861C194671627 @default.
- W3209324861 hasConceptScore W3209324861C195475562 @default.
- W3209324861 hasConceptScore W3209324861C203014093 @default.
- W3209324861 hasConceptScore W3209324861C2777237215 @default.
- W3209324861 hasConceptScore W3209324861C2778048844 @default.
- W3209324861 hasConceptScore W3209324861C2780900450 @default.
- W3209324861 hasConceptScore W3209324861C29730261 @default.
- W3209324861 hasConceptScore W3209324861C556039675 @default.
- W3209324861 hasConceptScore W3209324861C59822182 @default.
- W3209324861 hasConceptScore W3209324861C71924100 @default.
- W3209324861 hasConceptScore W3209324861C86803240 @default.
- W3209324861 hasConceptScore W3209324861C98274493 @default.
- W3209324861 hasIssue "1" @default.
- W3209324861 hasLocation W32093248611 @default.
- W3209324861 hasOpenAccess W3209324861 @default.
- W3209324861 hasPrimaryLocation W32093248611 @default.
- W3209324861 hasRelatedWork W168232003 @default.
- W3209324861 hasRelatedWork W2183872125 @default.
- W3209324861 hasRelatedWork W2333192791 @default.
- W3209324861 hasRelatedWork W2784760684 @default.
- W3209324861 hasRelatedWork W3090410541 @default.
- W3209324861 hasRelatedWork W3209324861 @default.
- W3209324861 hasRelatedWork W4206066382 @default.
- W3209324861 hasRelatedWork W4362685395 @default.
- W3209324861 hasRelatedWork W2187763688 @default.
- W3209324861 hasRelatedWork W2189227311 @default.
- W3209324861 hasVolume "10" @default.
- W3209324861 isParatext "false" @default.
- W3209324861 isRetracted "false" @default.
- W3209324861 magId "3209324861" @default.
- W3209324861 workType "article" @default.