FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3209325612> ?p ?o ?g. }

• W3209325612 endingPage "943" @default.
• W3209325612 startingPage "935" @default.
• W3209325612 abstract "To assess the efficacy and FVIII consumption of BAY 94-9027 versus N8-GP in prophylaxis in adolescent and adult patients with severe hemophilia A (HA).A systematic literature review was conducted to identify studies on the efficacy of BAY-94-9027 and N8-GP for prophylaxis in patients with HA aged ≥12 years without a history of inhibitors. Eight studies met systematic literature review inclusion criteria, but only data from PROTECT VIII on BAY 94-9027 and PATHFINDER 2 on N8-GP could be used for an indirect comparison. Matching-adjusted indirect comparison (MAIC) and simulated treatment comparison were performed.No significant differences (unadjusted and adjusted) were observed in the mean annualized bleeding rate (ABR) for any bleed and proportion of patients with zero bleeds when comparing BAY 94-9027 to N8-GP. The adjusted treatment difference [incidence rate ratio (IRR)] in terms of ABR was 1.11 (95% CI, 0.85-1.44). The odds ratio (OR) of any bleed, measuring the relative effect of BAY 94-9027 versus N8-GP on the proportion of patients with zero bleeds, was 1.03 (95% CI, 0.60-1.77). FVIII consumption was significantly lower in BAY 94-9027 [mean adjusted difference=-1292.57 IU/kg/year (95% CI, ‒2152.44 to ‒432.70)]; a 26.7% reduction in consumption of BAY-94-9027. The results of the sensitivity analyses were similar to the main analysis for mean ABRs, percentages of patients with zero bleeds, and significant reduction in rFVIII consumption. For patients on BAY 94-9027 every-5-days and every-7-days, no differences versus every-4-days N8-GP were observed for the mean ABR for any bleed [IRR=0.90 (95% CI, 0.68‒1.20)] and proportion of patients with zero bleeds [OR=1.06 (95% CI, 0.56‒2.02)].BAY 94-9027 prophylaxis demonstrated 26.7% lower annual consumption when compared to N8-GP with similar efficacy in terms of ABR and percentage of patients with zero bleeds." @default.
• W3209325612 created "2021-11-08" @default.
• W3209325612 creator A5018946153 @default.
• W3209325612 creator A5020918878 @default.
• W3209325612 creator A5033399787 @default.
• W3209325612 creator A5043641955 @default.
• W3209325612 creator A5046959234 @default.
• W3209325612 creator A5078942318 @default.
• W3209325612 creator A5083911927 @default.
• W3209325612 date "2021-11-01" @default.
• W3209325612 modified "2023-09-25" @default.
• W3209325612 title "Indirect Treatment Comparison of Damoctocog Alfa Pegol versus Turoctocog Alfa Pegol as Prophylactic Treatment in Patients with Hemophilia A" @default.
• W3209325612 cites W1623696825 @default.
• W3209325612 cites W2001886937 @default.
• W3209325612 cites W2013607072 @default.
• W3209325612 cites W2059843712 @default.
• W3209325612 cites W2090145179 @default.
• W3209325612 cites W2212870307 @default.
• W3209325612 cites W2417015270 @default.
• W3209325612 cites W2557462868 @default.
• W3209325612 cites W2566584570 @default.
• W3209325612 cites W2792202538 @default.
• W3209325612 cites W2793143008 @default.
• W3209325612 cites W2809892887 @default.
• W3209325612 cites W2920063431 @default.
• W3209325612 cites W2949365580 @default.
• W3209325612 cites W2951088829 @default.
• W3209325612 cites W2981289366 @default.
• W3209325612 cites W3029557309 @default.
• W3209325612 cites W3115286475 @default.
• W3209325612 cites W4246592208 @default.
• W3209325612 doi "https://doi.org/10.2147/jbm.s321288" @default.
• W3209325612 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8570287" @default.
• W3209325612 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34754257" @default.
• W3209325612 hasPublicationYear "2021" @default.
• W3209325612 type Work @default.
• W3209325612 sameAs 3209325612 @default.
• W3209325612 citedByCount "3" @default.
• W3209325612 countsByYear W32093256122023 @default.
• W3209325612 crossrefType "journal-article" @default.
• W3209325612 hasAuthorship W3209325612A5018946153 @default.
• W3209325612 hasAuthorship W3209325612A5020918878 @default.
• W3209325612 hasAuthorship W3209325612A5033399787 @default.
• W3209325612 hasAuthorship W3209325612A5043641955 @default.
• W3209325612 hasAuthorship W3209325612A5046959234 @default.
• W3209325612 hasAuthorship W3209325612A5078942318 @default.
• W3209325612 hasAuthorship W3209325612A5083911927 @default.
• W3209325612 hasBestOaLocation W32093256121 @default.
• W3209325612 hasConcept C115880899 @default.
• W3209325612 hasConcept C126322002 @default.
• W3209325612 hasConcept C127413603 @default.
• W3209325612 hasConcept C141071460 @default.
• W3209325612 hasConcept C147176958 @default.
• W3209325612 hasConcept C156957248 @default.
• W3209325612 hasConcept C2776259030 @default.
• W3209325612 hasConcept C71924100 @default.
• W3209325612 hasConceptScore W3209325612C115880899 @default.
• W3209325612 hasConceptScore W3209325612C126322002 @default.
• W3209325612 hasConceptScore W3209325612C127413603 @default.
• W3209325612 hasConceptScore W3209325612C141071460 @default.
• W3209325612 hasConceptScore W3209325612C147176958 @default.
• W3209325612 hasConceptScore W3209325612C156957248 @default.
• W3209325612 hasConceptScore W3209325612C2776259030 @default.
• W3209325612 hasConceptScore W3209325612C71924100 @default.
• W3209325612 hasLocation W32093256121 @default.
• W3209325612 hasLocation W32093256122 @default.
• W3209325612 hasLocation W32093256123 @default.
• W3209325612 hasLocation W32093256124 @default.
• W3209325612 hasLocation W32093256125 @default.
• W3209325612 hasOpenAccess W3209325612 @default.
• W3209325612 hasPrimaryLocation W32093256121 @default.
• W3209325612 hasRelatedWork W2003938723 @default.
• W3209325612 hasRelatedWork W2047967234 @default.
• W3209325612 hasRelatedWork W2118496982 @default.
• W3209325612 hasRelatedWork W2360716590 @default.
• W3209325612 hasRelatedWork W2364998975 @default.
• W3209325612 hasRelatedWork W2369162477 @default.
• W3209325612 hasRelatedWork W2439875401 @default.
• W3209325612 hasRelatedWork W2678470159 @default.
• W3209325612 hasRelatedWork W4238867864 @default.
• W3209325612 hasRelatedWork W2525756941 @default.
• W3209325612 hasVolume "Volume 12" @default.
• W3209325612 isParatext "false" @default.
• W3209325612 isRetracted "false" @default.
• W3209325612 magId "3209325612" @default.
• W3209325612 workType "article" @default.