FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3209378635> ?p ?o ?g. }

• W3209378635 abstract "Growing industrial use of carbon nanotubes and nanofibers (CNT/F) warrants consideration of human health outcomes. CNT/F produces pulmonary, cardiovascular, and other toxic effects in animals along with a significant release of bioactive peptides into the circulation, the augmented serum peptidome. While epidemiology among CNT/F workers reports on few acute symptoms, there remains concern over sub-clinical CNT/F effects that may prime for chronic disease, necessitating sensitive health outcome diagnostic markers for longitudinal follow-up.Here, the serum peptidome was assessed for its biomarker potential in detecting sub-symptomatic pathobiology among CNT/F workers using label-free data-independent mass spectrometry. Studies employed a stratified design between High (> 0.5 µg/m3) and Low (< 0.1 µg/m3) inhalable CNT/F exposures in the industrial setting. Peptide biomarker model building and refinement employed linear regression and partial least squared discriminant analyses. Top-ranked peptides were then sequence identified and evaluated for pathological-relevance.In total, 41 peptides were found to be highly discriminatory after model building with a strong linear correlation to personal CNT/F exposure. The top-five peptide model offered ideal prediction with high accuracy (Q2 = 0.99916). Unsupervised validation affirmed 43.5% of the serum peptidomic variance was attributable to CNT/F exposure. Peptide sequence identification reveals a predominant association with vascular pathology. ARHGAP21, ADAM15 and PLPP3 peptides suggest heightened cardiovasculature permeability and F13A1, FBN1 and VWDE peptides infer a pro-thrombotic state among High CNT/F workers.The serum peptidome affords a diagnostic window into sub-symptomatic pathology among CNT/F exposed workers for longitudinal monitoring of systemic health risks." @default.
• W3209378635 created "2021-11-08" @default.
• W3209378635 creator A5009948507 @default.
• W3209378635 creator A5019952224 @default.
• W3209378635 creator A5029332620 @default.
• W3209378635 creator A5041165353 @default.
• W3209378635 creator A5042231568 @default.
• W3209378635 creator A5044242893 @default.
• W3209378635 creator A5052347611 @default.
• W3209378635 creator A5061516111 @default.
• W3209378635 date "2021-10-28" @default.
• W3209378635 modified "2023-09-26" @default.
• W3209378635 title "Serum peptidome: diagnostic window into pathogenic processes following occupational exposure to carbon nanomaterials" @default.
• W3209378635 cites W176201993 @default.
• W3209378635 cites W1953921195 @default.
• W3209378635 cites W1965147942 @default.
• W3209378635 cites W1967249788 @default.
• W3209378635 cites W1969316714 @default.
• W3209378635 cites W1976416877 @default.
• W3209378635 cites W1979415542 @default.
• W3209378635 cites W1982264399 @default.
• W3209378635 cites W1991548496 @default.
• W3209378635 cites W1996767189 @default.
• W3209378635 cites W2003648250 @default.
• W3209378635 cites W2015999017 @default.
• W3209378635 cites W2016871586 @default.
• W3209378635 cites W2021558293 @default.
• W3209378635 cites W2022392583 @default.
• W3209378635 cites W2023626030 @default.
• W3209378635 cites W2037306255 @default.
• W3209378635 cites W2038317842 @default.
• W3209378635 cites W2041692988 @default.
• W3209378635 cites W2048234788 @default.
• W3209378635 cites W2052608599 @default.
• W3209378635 cites W2057663938 @default.
• W3209378635 cites W2059901024 @default.
• W3209378635 cites W2071624868 @default.
• W3209378635 cites W2076058780 @default.
• W3209378635 cites W2085523775 @default.
• W3209378635 cites W2098598082 @default.
• W3209378635 cites W2098722265 @default.
• W3209378635 cites W2099871684 @default.
• W3209378635 cites W2100370397 @default.
• W3209378635 cites W2105981176 @default.
• W3209378635 cites W2108252803 @default.
• W3209378635 cites W2109274354 @default.
• W3209378635 cites W2110766589 @default.
• W3209378635 cites W2116850938 @default.
• W3209378635 cites W2133246333 @default.
• W3209378635 cites W2134228812 @default.
• W3209378635 cites W2137766969 @default.
• W3209378635 cites W2151570064 @default.
• W3209378635 cites W2154396014 @default.
• W3209378635 cites W2216522720 @default.
• W3209378635 cites W2275623113 @default.
• W3209378635 cites W2308569764 @default.
• W3209378635 cites W2329954262 @default.
• W3209378635 cites W2332143474 @default.
• W3209378635 cites W2414205908 @default.
• W3209378635 cites W2470122983 @default.
• W3209378635 cites W2490424452 @default.
• W3209378635 cites W2515306133 @default.
• W3209378635 cites W2520222164 @default.
• W3209378635 cites W2522432693 @default.
• W3209378635 cites W2538106203 @default.
• W3209378635 cites W2566869394 @default.
• W3209378635 cites W2591366418 @default.
• W3209378635 cites W2597012859 @default.
• W3209378635 cites W2784304141 @default.
• W3209378635 cites W2786538622 @default.
• W3209378635 cites W2800331440 @default.
• W3209378635 cites W2807531409 @default.
• W3209378635 cites W2909035818 @default.
• W3209378635 cites W2912277923 @default.
• W3209378635 cites W2947567577 @default.
• W3209378635 cites W2972110711 @default.
• W3209378635 cites W3005476899 @default.
• W3209378635 cites W3005775962 @default.
• W3209378635 cites W3092958543 @default.
• W3209378635 cites W3111928832 @default.
• W3209378635 cites W3154352730 @default.
• W3209378635 cites W45534775 @default.
• W3209378635 doi "https://doi.org/10.1186/s12989-021-00431-0" @default.
• W3209378635 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8555107" @default.
• W3209378635 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34711247" @default.
• W3209378635 hasPublicationYear "2021" @default.
• W3209378635 type Work @default.
• W3209378635 sameAs 3209378635 @default.
• W3209378635 citedByCount "3" @default.
• W3209378635 countsByYear W32093786352022 @default.
• W3209378635 countsByYear W32093786352023 @default.
• W3209378635 crossrefType "journal-article" @default.
• W3209378635 hasAuthorship W3209378635A5009948507 @default.
• W3209378635 hasAuthorship W3209378635A5019952224 @default.
• W3209378635 hasAuthorship W3209378635A5029332620 @default.
• W3209378635 hasAuthorship W3209378635A5041165353 @default.
• W3209378635 hasAuthorship W3209378635A5042231568 @default.
• W3209378635 hasAuthorship W3209378635A5044242893 @default.
• W3209378635 hasAuthorship W3209378635A5052347611 @default.
• W3209378635 hasAuthorship W3209378635A5061516111 @default.

• next