Matches in SemOpenAlex for { <https://semopenalex.org/work/W3209415780> ?p ?o ?g. }
- W3209415780 endingPage "4227" @default.
- W3209415780 startingPage "4212" @default.
- W3209415780 abstract "Acute inflammation caused by bacterial infections is an essential biological defence mechanism of the host in order to neutralize and clear the invaders and to return to homeostasis. Despite its protective function, inflammation may become persistent and uncontrolled, resulting in chronic diseases and tissue destruction as consequence of the unresolved inflammatory process. Therefore, spatiotemporal induction of endogenous inflammation resolution programs that govern bacterial clearance as well as tissue repair and regeneration, are of major importance in order to enable tissues to restore functions. Lipid mediators that are de‐novo biosynthesized from polyunsaturated fatty acids (PUFAs) mainly by lipoxygenases and cyclooxygenases, critically regulate the initiation, the maintenance but also the resolution of infectious inflammation and tissue regeneration. The discovery of specialized pro‐resolving mediators (SPMs) generated from omega‐3 PUFAs stimulated intensive research in inflammation resolution, especially in infectious inflammation elicited by bacteria. SPMs are immunoresolvents that actively terminate inflammation by limiting neutrophil influx, stimulating phagocytosis, bacterial killing and clearance as well as efferocytosis of apoptotic neutrophils and cellular debris by macrophages. Moreover, SPMs prevent collateral tissue damage, promote tissue repair and regeneration and lower antibiotic requirement. Here, we review the biosynthesis of SPMs in bacterial infections and cover specific mechanisms of SPMs that govern the resolution of bacteria‐initiated inflammation." @default.
- W3209415780 created "2021-11-08" @default.
- W3209415780 creator A5023008183 @default.
- W3209415780 creator A5045395183 @default.
- W3209415780 date "2021-11-18" @default.
- W3209415780 modified "2023-10-15" @default.
- W3209415780 title "Specialized pro‐resolving mediators: biosynthesis and biological role in bacterial infections" @default.
- W3209415780 cites W1494464010 @default.
- W3209415780 cites W1497700962 @default.
- W3209415780 cites W1535815464 @default.
- W3209415780 cites W1538565107 @default.
- W3209415780 cites W1601517895 @default.
- W3209415780 cites W1836416096 @default.
- W3209415780 cites W1973193762 @default.
- W3209415780 cites W1974066136 @default.
- W3209415780 cites W1974226247 @default.
- W3209415780 cites W1975430023 @default.
- W3209415780 cites W1975531685 @default.
- W3209415780 cites W1975751417 @default.
- W3209415780 cites W1977471016 @default.
- W3209415780 cites W1977905350 @default.
- W3209415780 cites W1979659529 @default.
- W3209415780 cites W1986273261 @default.
- W3209415780 cites W1989856248 @default.
- W3209415780 cites W1996404624 @default.
- W3209415780 cites W2004536682 @default.
- W3209415780 cites W2007187686 @default.
- W3209415780 cites W2020561358 @default.
- W3209415780 cites W2024176341 @default.
- W3209415780 cites W2028906750 @default.
- W3209415780 cites W2030886691 @default.
- W3209415780 cites W2031084334 @default.
- W3209415780 cites W2042215223 @default.
- W3209415780 cites W2050362957 @default.
- W3209415780 cites W2070359486 @default.
- W3209415780 cites W2074692187 @default.
- W3209415780 cites W2080594285 @default.
- W3209415780 cites W2084117223 @default.
- W3209415780 cites W2089618876 @default.
- W3209415780 cites W2090609282 @default.
- W3209415780 cites W2094863064 @default.
- W3209415780 cites W2102189561 @default.
- W3209415780 cites W2103010344 @default.
- W3209415780 cites W2105788269 @default.
- W3209415780 cites W2118742454 @default.
- W3209415780 cites W2120699390 @default.
- W3209415780 cites W2122017112 @default.
- W3209415780 cites W2127604161 @default.
- W3209415780 cites W2134294696 @default.
- W3209415780 cites W2145946501 @default.
- W3209415780 cites W2148536296 @default.
- W3209415780 cites W2154748957 @default.
- W3209415780 cites W2156416313 @default.
- W3209415780 cites W2162465757 @default.
- W3209415780 cites W2184888523 @default.
- W3209415780 cites W2192331777 @default.
- W3209415780 cites W2198808464 @default.
- W3209415780 cites W2210741139 @default.
- W3209415780 cites W2266416617 @default.
- W3209415780 cites W2272063300 @default.
- W3209415780 cites W2284096089 @default.
- W3209415780 cites W2286411196 @default.
- W3209415780 cites W2291628580 @default.
- W3209415780 cites W2293029604 @default.
- W3209415780 cites W2293625454 @default.
- W3209415780 cites W2316741846 @default.
- W3209415780 cites W2321314291 @default.
- W3209415780 cites W2335925695 @default.
- W3209415780 cites W2341698863 @default.
- W3209415780 cites W2411841810 @default.
- W3209415780 cites W2507401895 @default.
- W3209415780 cites W2521020420 @default.
- W3209415780 cites W2540973436 @default.
- W3209415780 cites W2558506213 @default.
- W3209415780 cites W2562307887 @default.
- W3209415780 cites W2576089561 @default.
- W3209415780 cites W2579756956 @default.
- W3209415780 cites W2593211491 @default.
- W3209415780 cites W2593676156 @default.
- W3209415780 cites W2605253263 @default.
- W3209415780 cites W2606662408 @default.
- W3209415780 cites W2737388023 @default.
- W3209415780 cites W2739568820 @default.
- W3209415780 cites W2743599156 @default.
- W3209415780 cites W2752260686 @default.
- W3209415780 cites W2766246418 @default.
- W3209415780 cites W2778372284 @default.
- W3209415780 cites W2790138601 @default.
- W3209415780 cites W2791017891 @default.
- W3209415780 cites W2801066468 @default.
- W3209415780 cites W2802901067 @default.
- W3209415780 cites W2883180544 @default.
- W3209415780 cites W2892316903 @default.
- W3209415780 cites W2905294475 @default.
- W3209415780 cites W2910425223 @default.
- W3209415780 cites W2914637605 @default.
- W3209415780 cites W2950009659 @default.
- W3209415780 cites W2957454597 @default.