Matches in SemOpenAlex for { <https://semopenalex.org/work/W3209427366> ?p ?o ?g. }
- W3209427366 abstract "Lysocin E is a lipopeptide with antibiotic activity against methicillin-resistant Staphylococcus aureus. For unclear reasons, the antibacterial activity of lysocin E in a mouse systemic infection model is higher than expected from in vitro results, and the in vitro activity is enhanced by addition of bovine serum. Here, we confirm that serum from various species, including humans, increases lysocin E antimicrobial activity, and identify apolipoprotein A-I (ApoA-I) as an enhancing factor. ApoA-I increases the antibacterial activity of lysocin E when added in vitro, and the antibiotic displays reduced activity in ApoA-I gene knockout mice. Binding of ApoA-I to lysocin E is enhanced by lipid II, a cell-wall synthesis precursor found in the bacterial membrane. Thus, the antimicrobial activity of lysocin E is potentiated through interactions with host serum proteins and microbial components." @default.
- W3209427366 created "2021-11-08" @default.
- W3209427366 creator A5003851517 @default.
- W3209427366 creator A5012585624 @default.
- W3209427366 creator A5015297087 @default.
- W3209427366 creator A5036125797 @default.
- W3209427366 creator A5049635624 @default.
- W3209427366 creator A5050128143 @default.
- W3209427366 creator A5057751462 @default.
- W3209427366 creator A5061673601 @default.
- W3209427366 creator A5065487216 @default.
- W3209427366 creator A5067467084 @default.
- W3209427366 creator A5086986935 @default.
- W3209427366 date "2021-11-04" @default.
- W3209427366 modified "2023-10-14" @default.
- W3209427366 title "Serum apolipoprotein A-I potentiates the therapeutic efficacy of lysocin E against Staphylococcus aureus" @default.
- W3209427366 cites W1531230592 @default.
- W3209427366 cites W1557332392 @default.
- W3209427366 cites W1586229903 @default.
- W3209427366 cites W1790927204 @default.
- W3209427366 cites W1971806607 @default.
- W3209427366 cites W1974903759 @default.
- W3209427366 cites W1993558089 @default.
- W3209427366 cites W2003889403 @default.
- W3209427366 cites W2009001568 @default.
- W3209427366 cites W2012251902 @default.
- W3209427366 cites W2016872307 @default.
- W3209427366 cites W2019673246 @default.
- W3209427366 cites W2024670233 @default.
- W3209427366 cites W2030377661 @default.
- W3209427366 cites W2053529911 @default.
- W3209427366 cites W2054301035 @default.
- W3209427366 cites W2078829510 @default.
- W3209427366 cites W2081213583 @default.
- W3209427366 cites W2091085461 @default.
- W3209427366 cites W2099540110 @default.
- W3209427366 cites W2114579765 @default.
- W3209427366 cites W2116918625 @default.
- W3209427366 cites W2128254394 @default.
- W3209427366 cites W2135774757 @default.
- W3209427366 cites W2140147718 @default.
- W3209427366 cites W2140426405 @default.
- W3209427366 cites W2140880071 @default.
- W3209427366 cites W2150388094 @default.
- W3209427366 cites W2153920932 @default.
- W3209427366 cites W2166492699 @default.
- W3209427366 cites W2180304118 @default.
- W3209427366 cites W2194877626 @default.
- W3209427366 cites W2486016627 @default.
- W3209427366 cites W2531787923 @default.
- W3209427366 cites W2586337928 @default.
- W3209427366 cites W2593854886 @default.
- W3209427366 cites W2618803170 @default.
- W3209427366 cites W2770241117 @default.
- W3209427366 cites W2770346510 @default.
- W3209427366 cites W2784502358 @default.
- W3209427366 cites W2797779767 @default.
- W3209427366 cites W2897851159 @default.
- W3209427366 cites W2915235351 @default.
- W3209427366 cites W2920977377 @default.
- W3209427366 cites W2954519218 @default.
- W3209427366 cites W2955549808 @default.
- W3209427366 cites W2969414466 @default.
- W3209427366 cites W3040230712 @default.
- W3209427366 doi "https://doi.org/10.1038/s41467-021-26702-0" @default.
- W3209427366 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8568920" @default.
- W3209427366 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34737305" @default.
- W3209427366 hasPublicationYear "2021" @default.
- W3209427366 type Work @default.
- W3209427366 sameAs 3209427366 @default.
- W3209427366 citedByCount "11" @default.
- W3209427366 countsByYear W32094273662022 @default.
- W3209427366 countsByYear W32094273662023 @default.
- W3209427366 crossrefType "journal-article" @default.
- W3209427366 hasAuthorship W3209427366A5003851517 @default.
- W3209427366 hasAuthorship W3209427366A5012585624 @default.
- W3209427366 hasAuthorship W3209427366A5015297087 @default.
- W3209427366 hasAuthorship W3209427366A5036125797 @default.
- W3209427366 hasAuthorship W3209427366A5049635624 @default.
- W3209427366 hasAuthorship W3209427366A5050128143 @default.
- W3209427366 hasAuthorship W3209427366A5057751462 @default.
- W3209427366 hasAuthorship W3209427366A5061673601 @default.
- W3209427366 hasAuthorship W3209427366A5065487216 @default.
- W3209427366 hasAuthorship W3209427366A5067467084 @default.
- W3209427366 hasAuthorship W3209427366A5086986935 @default.
- W3209427366 hasBestOaLocation W32094273661 @default.
- W3209427366 hasConcept C104317684 @default.
- W3209427366 hasConcept C185592680 @default.
- W3209427366 hasConcept C202751555 @default.
- W3209427366 hasConcept C2777425210 @default.
- W3209427366 hasConcept C2778163477 @default.
- W3209427366 hasConcept C2779489039 @default.
- W3209427366 hasConcept C2780104969 @default.
- W3209427366 hasConcept C2780183148 @default.
- W3209427366 hasConcept C4937899 @default.
- W3209427366 hasConcept C501593827 @default.
- W3209427366 hasConcept C523546767 @default.
- W3209427366 hasConcept C54355233 @default.
- W3209427366 hasConcept C553450214 @default.
- W3209427366 hasConcept C55493867 @default.