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• W3209447050 endingPage "6537" @default.
• W3209447050 startingPage "6537" @default.
• W3209447050 abstract "Boron neutron capture therapy is a unique form of adjuvant cancer therapy for various malignancies including malignant gliomas. The conjugation of boron compounds and human serum albumin (HSA)-a carrier protein with a long plasma half-life-is expected to extend systemic circulation of the boron compounds and increase their accumulation in human glioma cells. We report on the synthesis of fluorophore-labeled homocystamide conjugates of human serum albumin and their use in thiol-'click' chemistry to prepare novel multimodal boronated albumin-based theranostic agents, which could be accumulated in tumor cells. The novelty of this work involves the development of the synthesis methodology of albumin conjugates for the imaging-guided boron neutron capture therapy combination. Herein, we suggest using thenoyltrifluoroacetone as a part of an anticancer theranostic construct: approximately 5.4 molecules of thenoyltrifluoroacetone were bound to each albumin. Along with its beneficial properties as a chemotherapeutic agent, thenoyltrifluoroacetone is a promising magnetic resonance imaging agent. The conjugation of bimodal HSA with undecahydro-closo-dodecaborate only slightly reduced human glioma cell line viability in the absence of irradiation (~30 μM of boronated albumin) but allowed for neutron capture and decreased tumor cell survival under epithermal neutron flux. The simultaneous presence of undecahydro-closo-dodecaborate and labeled amino acid residues (fluorophore dye and fluorine atoms) in the obtained HSA conjugate makes it a promising candidate for the combination imaging-guided boron neutron capture therapy." @default.
• W3209447050 created "2021-11-08" @default.
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• W3209447050 date "2021-10-29" @default.
• W3209447050 modified "2023-10-16" @default.
• W3209447050 title "Homocystamide Conjugates of Human Serum Albumin as a Platform to Prepare Bimodal Multidrug Delivery Systems for Boron Neutron Capture Therapy" @default.
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• W3209447050 doi "https://doi.org/10.3390/molecules26216537" @default.
• W3209447050 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8586956" @default.
• W3209447050 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34770947" @default.
• W3209447050 hasPublicationYear "2021" @default.
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