FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3209464783> ?p ?o ?g. }

• W3209464783 endingPage "1754.e8" @default.
• W3209464783 startingPage "1744" @default.
• W3209464783 abstract "Hematopoietic stem cell transplantation (HSCT) represents a curative treatment for patients with severe combined immunodeficiency (SCID), a group of monogenic immune disorders with an otherwise fatal outcome.We performed a comprehensive multicenter analysis of genotype-specific HSCT outcome, including detailed analysis of immune reconstitution (IR) and the predictive value for clinical outcome.HSCT outcome was studied in 338 patients with genetically confirmed SCID who underwent transplantation in 2006-2014 and who were registered in the SCETIDE registry. In a representative subgroup of 152 patients, data on IR and long-term clinical outcome were analyzed.Two-year OS was similar with matched family and unrelated donors and better than mismatched donor HSCT (P < .001). The 2-year event-free survival (EFS) was similar in matched and mismatched unrelated donor and less favorable in mismatched related donor (MMRD) HSCT (P < .001). Genetic subgroups did not differ in 2-year OS (P = .1) and EFS (P = .073). In multivariate analysis, pretransplantation infections and use of MMRDs were associated with less favorable OS and EFS. With a median follow-up of 6.2 years (range, 2.0-11.8 years), 73 of 152 patients in the IR cohort were alive and well without Ig dependency. IL-2 receptor gamma chain/Janus kinase 3/IL-7 receptor-deficient SCID, myeloablative conditioning, matched donor HSCT, and naive CD4 T lymphocytes >0.5 × 10e3/μL at +1 year were identified as independent predictors of favorable clinical and immunologic outcome.Recent advances in HSCT in SCID patients have resulted in improved OS and EFS in all genotypes and donor types. To achieve a favorable long-term outcome, treatment strategies should aim for optimal naive CD4 T lymphocyte regeneration." @default.
• W3209464783 created "2021-11-08" @default.
• W3209464783 creator A5000382317 @default.
• W3209464783 creator A5000858647 @default.
• W3209464783 creator A5001630246 @default.
• W3209464783 creator A5002489212 @default.
• W3209464783 creator A5003067125 @default.
• W3209464783 creator A5005040866 @default.
• W3209464783 creator A5005573514 @default.
• W3209464783 creator A5006102363 @default.
• W3209464783 creator A5008743000 @default.
• W3209464783 creator A5009510239 @default.
• W3209464783 creator A5010556604 @default.
• W3209464783 creator A5013190832 @default.
• W3209464783 creator A5013983797 @default.
• W3209464783 creator A5014175225 @default.
• W3209464783 creator A5014207275 @default.
• W3209464783 creator A5014990865 @default.
• W3209464783 creator A5016105550 @default.
• W3209464783 creator A5019188950 @default.
• W3209464783 creator A5019781329 @default.
• W3209464783 creator A5021572787 @default.
• W3209464783 creator A5028292912 @default.
• W3209464783 creator A5029004287 @default.
• W3209464783 creator A5029304342 @default.
• W3209464783 creator A5029816641 @default.
• W3209464783 creator A5030851924 @default.
• W3209464783 creator A5031098425 @default.
• W3209464783 creator A5032520604 @default.
• W3209464783 creator A5034423434 @default.
• W3209464783 creator A5037313274 @default.
• W3209464783 creator A5044249462 @default.
• W3209464783 creator A5045322247 @default.
• W3209464783 creator A5050682361 @default.
• W3209464783 creator A5050745478 @default.
• W3209464783 creator A5051621566 @default.
• W3209464783 creator A5052353546 @default.
• W3209464783 creator A5052361337 @default.
• W3209464783 creator A5054904756 @default.
• W3209464783 creator A5056892740 @default.
• W3209464783 creator A5058130884 @default.
• W3209464783 creator A5058502232 @default.
• W3209464783 creator A5058861543 @default.
• W3209464783 creator A5061463272 @default.
• W3209464783 creator A5064058270 @default.
• W3209464783 creator A5064468034 @default.
• W3209464783 creator A5068635503 @default.
• W3209464783 creator A5069107002 @default.
• W3209464783 creator A5069128648 @default.
• W3209464783 creator A5071364391 @default.
• W3209464783 creator A5073001580 @default.
• W3209464783 creator A5075839647 @default.
• W3209464783 creator A5076117076 @default.
• W3209464783 creator A5076169728 @default.
• W3209464783 creator A5078800018 @default.
• W3209464783 creator A5082007290 @default.
• W3209464783 creator A5086233617 @default.
• W3209464783 creator A5086385261 @default.
• W3209464783 creator A5087818948 @default.
• W3209464783 creator A5090000319 @default.
• W3209464783 date "2022-05-01" @default.
• W3209464783 modified "2023-10-17" @default.
• W3209464783 title "Hematopoietic cell transplantation in severe combined immunodeficiency: The SCETIDE 2006-2014 European cohort" @default.
• W3209464783 cites W1576043159 @default.
• W3209464783 cites W1978341830 @default.
• W3209464783 cites W2009394284 @default.
• W3209464783 cites W2060662421 @default.
• W3209464783 cites W2065910655 @default.
• W3209464783 cites W2088882275 @default.
• W3209464783 cites W2100304556 @default.
• W3209464783 cites W2122153475 @default.
• W3209464783 cites W2152461163 @default.
• W3209464783 cites W2170677852 @default.
• W3209464783 cites W2588670026 @default.
• W3209464783 cites W2743113491 @default.
• W3209464783 cites W2762629706 @default.
• W3209464783 cites W2770403440 @default.
• W3209464783 cites W2801448223 @default.
• W3209464783 cites W2887096319 @default.
• W3209464783 cites W2889412507 @default.
• W3209464783 cites W2910184421 @default.
• W3209464783 cites W2912749691 @default.
• W3209464783 cites W2914985409 @default.
• W3209464783 cites W2921075494 @default.
• W3209464783 cites W2970334679 @default.
• W3209464783 cites W2972071232 @default.
• W3209464783 cites W2975502554 @default.
• W3209464783 cites W2981550624 @default.
• W3209464783 cites W2991518933 @default.
• W3209464783 cites W3000301584 @default.
• W3209464783 cites W3038542904 @default.
• W3209464783 cites W3040732116 @default.
• W3209464783 cites W3162626720 @default.
• W3209464783 cites W3187152632 @default.
• W3209464783 doi "https://doi.org/10.1016/j.jaci.2021.10.017" @default.
• W3209464783 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34718043" @default.
• W3209464783 hasPublicationYear "2022" @default.
• W3209464783 type Work @default.

• next