FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3209493952> ?p ?o ?g. }

• W3209493952 endingPage "S1267" @default.
• W3209493952 startingPage "S1266" @default.
• W3209493952 abstract "Introduction: Sclerosing mesenteritis (SM) refers to a spectrum of inflammatory disorders of the bowel mesentery adipose tissue whose pathogenesis is poorly understood, but has been associated with prior abdominal surgery, malignancy, and autoimmune disease. Patients can be asymptomatic or have non-specific abdominal complaints. Diagnosis can be made radiographically, but tissue is required for definitive evaluation. We present a case of severe constipation and abdominal distention due to sclerosing mesenteritis. Case Description/Methods: A 55-year-old male presented with two months of constipation, abdominal pain, and severe distention impairing ability to wear regular-sized clothing. Initial laboratory evaluation was normal, CTAP revealed no obstruction, and colonoscopy was normal. A trial of linaclotide briefly improved symptoms, however he re-presented to an ED with severe pain where CTAP showed an ovoid expansile region of mesenteric haziness within the central abdomen, encircling the mesenteric root vessels, reflecting SM with mass effect on the surrounding bowel (Figure 1A). PET/CT did not show evidence of malignancy. Laparoscopic mesenteric biopsy revealed areas of fat necrosis with associated lipid-laden macrophages; fibrosis was not identified, plasma cells were not prominent, and IgG4 positive cells were absent. Immunostains were negative. Laboratory evaluation was notable for: borderline ANA titer 1:80, positive fibrillarin antibody, and negative Scl-70. Systemic steroids were initiated with some improvement in symptoms, and tamoxifen was later added. Discussion: Sclerosing mesenteritis is a rare inflammatory, fibrotic disease of bowel mesentery fat tissue whose presentation ranges from asymptomatic to severe pain and bowel changes due to obstruction. While its exact pathogenesis is unclear, it may be related to prior surgery, underlying malignancy (eg. lymphoma) or an autoimmune etiology (due to association with conditions such as primary sclerosing cholangitis and retroperitoneal fibrosis). Diagnosis is challenging; CT scan is the most sensitive test, but histological analysis is necessary to evaluate for any underlying etiologies. There is no definitive therapy, but systemic steroids and antifibrotic agents such as tamoxifen have been studied; some patients require surgical resection.Figure 1.: CT-Abdomen and Pelvis: An ovoid expansile region of mesenteric haziness within the central abdomen, encircling the mesenteric root vessels, reflecting sclerosing mesenteritis with mass effect on the surrounding bowel loops." @default.
• W3209493952 created "2021-11-08" @default.
• W3209493952 creator A5048048504 @default.
• W3209493952 creator A5059607973 @default.
• W3209493952 creator A5062791085 @default.
• W3209493952 creator A5081788151 @default.
• W3209493952 date "2021-10-01" @default.
• W3209493952 modified "2023-09-27" @default.
• W3209493952 title "S3069 A Disease of Many Names: Sclerosing Mesenteritis" @default.
• W3209493952 doi "https://doi.org/10.14309/01.ajg.0000785808.60046.aa" @default.
• W3209493952 hasPublicationYear "2021" @default.
• W3209493952 type Work @default.
• W3209493952 sameAs 3209493952 @default.
• W3209493952 citedByCount "0" @default.
• W3209493952 crossrefType "journal-article" @default.
• W3209493952 hasAuthorship W3209493952A5048048504 @default.
• W3209493952 hasAuthorship W3209493952A5059607973 @default.
• W3209493952 hasAuthorship W3209493952A5062791085 @default.
• W3209493952 hasAuthorship W3209493952A5081788151 @default.
• W3209493952 hasBestOaLocation W32094939521 @default.
• W3209493952 hasConcept C121608353 @default.
• W3209493952 hasConcept C126322002 @default.
• W3209493952 hasConcept C126838900 @default.
• W3209493952 hasConcept C142724271 @default.
• W3209493952 hasConcept C2775934546 @default.
• W3209493952 hasConcept C2777910003 @default.
• W3209493952 hasConcept C2778260677 @default.
• W3209493952 hasConcept C2778435480 @default.
• W3209493952 hasConcept C2778948390 @default.
• W3209493952 hasConcept C2779134260 @default.
• W3209493952 hasConcept C2779399171 @default.
• W3209493952 hasConcept C2779983558 @default.
• W3209493952 hasConcept C2780955771 @default.
• W3209493952 hasConcept C526805850 @default.
• W3209493952 hasConcept C71924100 @default.
• W3209493952 hasConcept C90924648 @default.
• W3209493952 hasConceptScore W3209493952C121608353 @default.
• W3209493952 hasConceptScore W3209493952C126322002 @default.
• W3209493952 hasConceptScore W3209493952C126838900 @default.
• W3209493952 hasConceptScore W3209493952C142724271 @default.
• W3209493952 hasConceptScore W3209493952C2775934546 @default.
• W3209493952 hasConceptScore W3209493952C2777910003 @default.
• W3209493952 hasConceptScore W3209493952C2778260677 @default.
• W3209493952 hasConceptScore W3209493952C2778435480 @default.
• W3209493952 hasConceptScore W3209493952C2778948390 @default.
• W3209493952 hasConceptScore W3209493952C2779134260 @default.
• W3209493952 hasConceptScore W3209493952C2779399171 @default.
• W3209493952 hasConceptScore W3209493952C2779983558 @default.
• W3209493952 hasConceptScore W3209493952C2780955771 @default.
• W3209493952 hasConceptScore W3209493952C526805850 @default.
• W3209493952 hasConceptScore W3209493952C71924100 @default.
• W3209493952 hasConceptScore W3209493952C90924648 @default.
• W3209493952 hasIssue "1" @default.
• W3209493952 hasLocation W32094939521 @default.
• W3209493952 hasLocation W32094939522 @default.
• W3209493952 hasOpenAccess W3209493952 @default.
• W3209493952 hasPrimaryLocation W32094939521 @default.
• W3209493952 hasRelatedWork W1970829184 @default.
• W3209493952 hasRelatedWork W1975032444 @default.
• W3209493952 hasRelatedWork W2017993548 @default.
• W3209493952 hasRelatedWork W2019857031 @default.
• W3209493952 hasRelatedWork W2074554504 @default.
• W3209493952 hasRelatedWork W2384196439 @default.
• W3209493952 hasRelatedWork W2474068478 @default.
• W3209493952 hasRelatedWork W3020811650 @default.
• W3209493952 hasRelatedWork W3021779352 @default.
• W3209493952 hasRelatedWork W3171911296 @default.
• W3209493952 hasVolume "116" @default.
• W3209493952 isParatext "false" @default.
• W3209493952 isRetracted "false" @default.
• W3209493952 magId "3209493952" @default.
• W3209493952 workType "article" @default.