FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3209498911> ?p ?o ?g. }

• W3209498911 endingPage "113907" @default.
• W3209498911 startingPage "113907" @default.
• W3209498911 abstract "Propensity to relapse, even after long-term abstinence, is a crucial feature of methamphetamine (METH) abuse. We and other laboratories have reported that acute treatment of oxytocin (OXT), a hormone and neuropeptide, could inhibit reinstatement of METH seeking in animal studies. However, the effects of repeated OXT treatment on METH reinstatement as well as underlying mechanisms are still unclear. In the present study, the effects of repeated OXT treatment during abstinence on context- or restraint stress-induced reinstatement were investigated using the mice conditioned place preference (CPP) paradigm. After three intermittent injections of METH (2 mg/kg, i.p.) to induce CPP, mice received a daily bilateral intra-hippocampus injection of OXT (0.625, 1.25 or 2.5 μg) for 8 consecutive days before the context- or restraint stress-induced reinstatement test. Meanwhile, adult hippocampal neurogenesis (AHN) level was detected using immunostaining. To further clarify the role of AHN underlying OXT's effects on METH-CPP reinstatement, temozolomide (TMZ, 25 mg/kg, i.p.) was employed to deplete AHN prior to OXT treatment. The data showed that repeated OXT treatment (1.25 and 2.5 μg, intra-hippocampus) significantly inhibited both context- and restraint stress-induced METH-CPP reinstatement and concomitantly promoted AHN in a dose-dependent manner. Notably, TMZ pre-treatment markedly abolished all the above-mentioned effects of OXT, suggesting that AHN was closely involved in OXT's inhibition on reinstatement induced by both triggers. Taken together, the present study indicated that repeated OXT treatment during abstinence could inhibit both context- and restraint stress-induced METH-CPP reinstatement possibly by promoting AHN in mice, which provided a better understanding for OXT's beneficial effects on METH addiction." @default.
• W3209498911 created "2021-11-08" @default.
• W3209498911 creator A5013249245 @default.
• W3209498911 creator A5028019357 @default.
• W3209498911 creator A5040299845 @default.
• W3209498911 creator A5052943350 @default.
• W3209498911 creator A5055758813 @default.
• W3209498911 creator A5057336191 @default.
• W3209498911 creator A5067614734 @default.
• W3209498911 creator A5076784980 @default.
• W3209498911 date "2022-01-01" @default.
• W3209498911 modified "2023-09-23" @default.
• W3209498911 title "Repeated oxytocin treatment during abstinence inhibited context- or restraint stress-induced reinstatement of methamphetamine-conditioned place preference and promoted adult hippocampal neurogenesis in mice" @default.
• W3209498911 cites W1540177567 @default.
• W3209498911 cites W1541419652 @default.
• W3209498911 cites W1592428004 @default.
• W3209498911 cites W1898877040 @default.
• W3209498911 cites W1954057881 @default.
• W3209498911 cites W1972421000 @default.
• W3209498911 cites W1973214775 @default.
• W3209498911 cites W1985605151 @default.
• W3209498911 cites W1991163868 @default.
• W3209498911 cites W1998154386 @default.
• W3209498911 cites W2001036497 @default.
• W3209498911 cites W2006780539 @default.
• W3209498911 cites W2009542179 @default.
• W3209498911 cites W2019741006 @default.
• W3209498911 cites W2019888004 @default.
• W3209498911 cites W2023343492 @default.
• W3209498911 cites W2028244020 @default.
• W3209498911 cites W2047831967 @default.
• W3209498911 cites W2051005796 @default.
• W3209498911 cites W2066625945 @default.
• W3209498911 cites W2076518235 @default.
• W3209498911 cites W2090086966 @default.
• W3209498911 cites W2095898364 @default.
• W3209498911 cites W2098536790 @default.
• W3209498911 cites W2115290127 @default.
• W3209498911 cites W2117506912 @default.
• W3209498911 cites W2130169724 @default.
• W3209498911 cites W2140834792 @default.
• W3209498911 cites W2160071886 @default.
• W3209498911 cites W2462199783 @default.
• W3209498911 cites W2515748080 @default.
• W3209498911 cites W2528708709 @default.
• W3209498911 cites W2557831994 @default.
• W3209498911 cites W2601916337 @default.
• W3209498911 cites W2605224586 @default.
• W3209498911 cites W2676255039 @default.
• W3209498911 cites W2755340369 @default.
• W3209498911 cites W2767730684 @default.
• W3209498911 cites W2783921342 @default.
• W3209498911 cites W2784673699 @default.
• W3209498911 cites W2788841756 @default.
• W3209498911 cites W2792606345 @default.
• W3209498911 cites W2799687824 @default.
• W3209498911 cites W2801272424 @default.
• W3209498911 cites W2863633805 @default.
• W3209498911 cites W2890292556 @default.
• W3209498911 cites W2913288555 @default.
• W3209498911 cites W2917404940 @default.
• W3209498911 cites W2956154541 @default.
• W3209498911 cites W2958747473 @default.
• W3209498911 cites W2985482601 @default.
• W3209498911 cites W2987772439 @default.
• W3209498911 cites W2999600065 @default.
• W3209498911 cites W3037694587 @default.
• W3209498911 cites W3127665251 @default.
• W3209498911 cites W3130700614 @default.
• W3209498911 cites W3180479560 @default.
• W3209498911 cites W581256308 @default.
• W3209498911 doi "https://doi.org/10.1016/j.expneurol.2021.113907" @default.
• W3209498911 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34715133" @default.
• W3209498911 hasPublicationYear "2022" @default.
• W3209498911 type Work @default.
• W3209498911 sameAs 3209498911 @default.
• W3209498911 citedByCount "5" @default.
• W3209498911 countsByYear W32094989112021 @default.
• W3209498911 countsByYear W32094989112022 @default.
• W3209498911 countsByYear W32094989112023 @default.
• W3209498911 crossrefType "journal-article" @default.
• W3209498911 hasAuthorship W3209498911A5013249245 @default.
• W3209498911 hasAuthorship W3209498911A5028019357 @default.
• W3209498911 hasAuthorship W3209498911A5040299845 @default.
• W3209498911 hasAuthorship W3209498911A5052943350 @default.
• W3209498911 hasAuthorship W3209498911A5055758813 @default.
• W3209498911 hasAuthorship W3209498911A5057336191 @default.
• W3209498911 hasAuthorship W3209498911A5067614734 @default.
• W3209498911 hasAuthorship W3209498911A5076784980 @default.
• W3209498911 hasConcept C118303440 @default.
• W3209498911 hasConcept C118552586 @default.
• W3209498911 hasConcept C126322002 @default.
• W3209498911 hasConcept C134018914 @default.
• W3209498911 hasConcept C148762608 @default.
• W3209498911 hasConcept C151730666 @default.
• W3209498911 hasConcept C15744967 @default.
• W3209498911 hasConcept C166940927 @default.
• W3209498911 hasConcept C169760540 @default.

• next