Matches in SemOpenAlex for { <https://semopenalex.org/work/W3209507066> ?p ?o ?g. }
- W3209507066 endingPage "1162" @default.
- W3209507066 startingPage "1149" @default.
- W3209507066 abstract "This study aimed to clarify the regulatory role of Th17-Treg balance in periodontitis and further reveal Treg plasticity.An experimental periodontitis model was established by ligation and injection of Pg-LPS. Inflammatory factors were measured by ELISA and RT-PCR. Alveolar bone absorption was evaluated by micro-CT and histomorphology. Quantities of Treg and Th17 cell and their related gene expression were examined. Furthermore, after magnetic bead-sorting spleen Treg cells, Treg/Th17 characteristic genes were explored. Immunofluorescence double staining of Foxp3 and IL-17 was conducted to further reveal Treg plasticity.Inflammatory cytokines in serum and gingival tissue increased significantly in periodontitis, which revealed obvious crestal bone loss. Further analysis showed that the number of Th17 cells and expression of related genes increased more significantly than Treg cells, demonstrating Treg-Th17 imbalance. Flow cytometry showed that the proportions of Treg cells in the blood and spleen were lower in periodontitis group. Furthermore, Foxp3 was downregulated, and Rorc/ IL-17A were increased in Treg cells of periodontitis group. Immunofluorescence double staining showed significantly increased number of IL-17+Foxp3+ cells in periodontitis.These results provided evidence that Treg cells showed characteristics of Th17 cells in mice with periodontitis, although its mechanisms require further study." @default.
- W3209507066 created "2021-11-08" @default.
- W3209507066 creator A5000602103 @default.
- W3209507066 creator A5004395331 @default.
- W3209507066 creator A5028576686 @default.
- W3209507066 creator A5030725667 @default.
- W3209507066 creator A5037970606 @default.
- W3209507066 creator A5056840842 @default.
- W3209507066 creator A5062071376 @default.
- W3209507066 date "2021-11-12" @default.
- W3209507066 modified "2023-10-17" @default.
- W3209507066 title "Regulatory T cells showed characteristics of T helper‐17(Th17) cells in mice periodontitis model" @default.
- W3209507066 cites W1528084970 @default.
- W3209507066 cites W1987802826 @default.
- W3209507066 cites W2003324119 @default.
- W3209507066 cites W2027646748 @default.
- W3209507066 cites W2035555189 @default.
- W3209507066 cites W2036117709 @default.
- W3209507066 cites W2043776488 @default.
- W3209507066 cites W2049967795 @default.
- W3209507066 cites W2055603849 @default.
- W3209507066 cites W2062522397 @default.
- W3209507066 cites W2066521804 @default.
- W3209507066 cites W2084007358 @default.
- W3209507066 cites W2085253026 @default.
- W3209507066 cites W2104369318 @default.
- W3209507066 cites W2104401957 @default.
- W3209507066 cites W2107786131 @default.
- W3209507066 cites W2111914463 @default.
- W3209507066 cites W2120010406 @default.
- W3209507066 cites W2120741277 @default.
- W3209507066 cites W2127483675 @default.
- W3209507066 cites W2138257851 @default.
- W3209507066 cites W2142017607 @default.
- W3209507066 cites W2143100947 @default.
- W3209507066 cites W2152642587 @default.
- W3209507066 cites W2166508471 @default.
- W3209507066 cites W2193676377 @default.
- W3209507066 cites W2306484536 @default.
- W3209507066 cites W2483681232 @default.
- W3209507066 cites W2511627766 @default.
- W3209507066 cites W2529152595 @default.
- W3209507066 cites W2536653177 @default.
- W3209507066 cites W2602724180 @default.
- W3209507066 cites W2795665486 @default.
- W3209507066 cites W2889955262 @default.
- W3209507066 cites W2896857921 @default.
- W3209507066 cites W2897795153 @default.
- W3209507066 cites W2947661946 @default.
- W3209507066 cites W2961107174 @default.
- W3209507066 cites W3011062320 @default.
- W3209507066 cites W3168058619 @default.
- W3209507066 doi "https://doi.org/10.1111/odi.14072" @default.
- W3209507066 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34741371" @default.
- W3209507066 hasPublicationYear "2021" @default.
- W3209507066 type Work @default.
- W3209507066 sameAs 3209507066 @default.
- W3209507066 citedByCount "3" @default.
- W3209507066 countsByYear W32095070662022 @default.
- W3209507066 countsByYear W32095070662023 @default.
- W3209507066 crossrefType "journal-article" @default.
- W3209507066 hasAuthorship W3209507066A5000602103 @default.
- W3209507066 hasAuthorship W3209507066A5004395331 @default.
- W3209507066 hasAuthorship W3209507066A5028576686 @default.
- W3209507066 hasAuthorship W3209507066A5030725667 @default.
- W3209507066 hasAuthorship W3209507066A5037970606 @default.
- W3209507066 hasAuthorship W3209507066A5056840842 @default.
- W3209507066 hasAuthorship W3209507066A5062071376 @default.
- W3209507066 hasConcept C126322002 @default.
- W3209507066 hasConcept C159654299 @default.
- W3209507066 hasConcept C203014093 @default.
- W3209507066 hasConcept C2776914184 @default.
- W3209507066 hasConcept C2778236600 @default.
- W3209507066 hasConcept C2779727006 @default.
- W3209507066 hasConcept C2780385504 @default.
- W3209507066 hasConcept C2780931953 @default.
- W3209507066 hasConcept C47348012 @default.
- W3209507066 hasConcept C553184892 @default.
- W3209507066 hasConcept C71924100 @default.
- W3209507066 hasConcept C74737994 @default.
- W3209507066 hasConcept C8891405 @default.
- W3209507066 hasConceptScore W3209507066C126322002 @default.
- W3209507066 hasConceptScore W3209507066C159654299 @default.
- W3209507066 hasConceptScore W3209507066C203014093 @default.
- W3209507066 hasConceptScore W3209507066C2776914184 @default.
- W3209507066 hasConceptScore W3209507066C2778236600 @default.
- W3209507066 hasConceptScore W3209507066C2779727006 @default.
- W3209507066 hasConceptScore W3209507066C2780385504 @default.
- W3209507066 hasConceptScore W3209507066C2780931953 @default.
- W3209507066 hasConceptScore W3209507066C47348012 @default.
- W3209507066 hasConceptScore W3209507066C553184892 @default.
- W3209507066 hasConceptScore W3209507066C71924100 @default.
- W3209507066 hasConceptScore W3209507066C74737994 @default.
- W3209507066 hasConceptScore W3209507066C8891405 @default.
- W3209507066 hasFunder F4320321001 @default.
- W3209507066 hasIssue "3" @default.
- W3209507066 hasLocation W32095070661 @default.
- W3209507066 hasLocation W32095070662 @default.