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- W3209508086 abstract "In his Perspective “Treatments for Alzheimer’s disease emerge” (6 August, p. 624), D. J. Selkoe asserts that some trials testing potential treatments for Alzheimer’s disease have shown “evidence of disease modification.” He cites reductions in amyloid plaques (hypothesized to cause cognitive decline) and some modest reductions in cognitive decline shown in four potential drugs that target amyloid. However, hardly any trials have shown an effect, and even the trials with statistically significant results show effects that are too small to be clinically significant or to justify moving forward with the treatments. β-amyloid antibodies can lower amyloid plaques (extracellular aggregated insoluble β-amyloid), but available data show that decreasing amyloid plaques does not in itself lead to reduction in cognitive decline." @default.
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- W3209508086 date "2021-10-29" @default.
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- W3209508086 title "Alzheimer’s drugs: Does reducing amyloid work?" @default.
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- W3209508086 doi "https://doi.org/10.1126/science.abl8366" @default.
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