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- W3209568681 abstract "Abstract Multiple embryonic precursors give rise to leukocytes in adults while the lineage‐based functional impacts are underappreciated. Mesodermal precursors expressing PDGFRα appear transiently during E7.5‐8.5 descend to a subset of Lin – Sca1 + Kit + hematopoietic progenitors found in adult BM. By analyzing a PDGFRα‐lineage tracing mouse line, we here report that PDGFRα‐lineage BM F4/80 + SSC lo monocytes/macrophages are solely Ly6C + LFA‐1 hi Mac‐1 hi monocytes enriched on the abluminal sinusoidal endothelium while Ly6C – LFA‐1 lo Mac‐1 lo macrophages are mostly from non‐PDGFRα‐lineage in vivo. Monocytes with stronger integrin profiles outcompete macrophages for adhesion on an endothelial monolayer or surfaces coated with ICAM‐1‐Fc or VCAM‐1‐Fc. Egress of PDGFRα‐lineage‐rich monocytes and subsequent differentiation to peripheral macrophages spatially segregates them from non‐PDGFRα‐lineage BM‐resident macrophages and allows functional specialization since macrophages derived from these egressing monocytes differ in morphology, phenotype, and functionality from BM‐resident macrophages in culture. Extravasation preference for blood PDGFRα‐lineage monocytes varies by tissues and governs the local lineage composition of macrophages. More PDGFRα‐lineage classical monocytes infiltrated into skin and colon but not into peritoneum. Accordingly, transcriptomic analytics indicated augmented inflammatory cascades in dermatitis skin of BM‐chimeric mice harbouring only PDGFRα‐lineage leukocytes. Thus, the PDGFRα‐lineage origin biasedly generates monocytes predestined for BM exit to support peripheral immunity following extravasation and macrophage differentiation." @default.
- W3209568681 created "2021-11-08" @default.
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- W3209568681 date "2021-11-15" @default.
- W3209568681 modified "2023-10-16" @default.
- W3209568681 title "PDGFRα lineage origin directs monocytes to trafficking proficiency to support peripheral immunity" @default.
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- W3209568681 doi "https://doi.org/10.1002/eji.202149479" @default.
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