FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3209573214> ?p ?o ?g. }

• W3209573214 endingPage "S1038" @default.
• W3209573214 startingPage "S1038" @default.
• W3209573214 abstract "Introduction: Miliary tuberculosis results from massive hematogenous dissemination of tuberculosis (TB) typically to the lung, bone, and less commonly to the gastrointestinal tract. It accounts for 2% of TB cases which may present as a life-threatening septic shock in the setting immunosuppression. Case Description/Methods: A 53-year-old Cuban male physician with moderate to severe ileocolic Crohn's disease and a history of travel to Cuba was recently initiated on Infliximab due to the failure of conventional therapy. Pretreatment Interferon-γ Release Assay (IGRA) QuantiFERON-TB Gold In-Tube, and tuberculin skin test were negative. Fourteen weeks later, he reported fever, emesis, and unintentional weight loss. Colonoscopy revealed severely inflamed mucosa of the right hemi-colon promoting escalation of infliximab dose with steroids for a presumed CD flare. Biopsy subsequently revealed numerous acid-fast bacilli. Therapy was immediately aborted, and he was then advised to initiate TB treatment. He returned eight days later with shock progressing to multiorgan failure. During emergent exploratory laparotomy, the small bowel and omentum were studded with white granulomatous nodules. He expired n the first postoperative day. Sputum, omentum, and abdominal wall cultures were all positive for Mycobacterium tuberculosis, and repeat IGRA was indeterminate. Discussion: Crohn’s disease (CD) is a chronic granulomatous inflammatory and destructive disease which follows a relapsing and remitting course. Infliximab therapy is initiated in moderate to severe stages however it carries with it an increased risk of reactivation of latent TB. IGRA testing before and during treatment is important during treatment with infliximab. It is difficult to surmise whether the subsequent hospital visits post infliximab initiation were due to worsening CD, or a manifestation of intestinal TB given the striking similarities. This patient’s insidious weight loss and rapid decline concomitant with the escalation of Infliximab and corticosteroid use points towards intestinal TB as the etiology of the symptoms. Despite the high sensitivity of IGRA testing, this patient’s travel history in an endemic area decreases the negative predictive value of the test. Diagnosis of miliary TB is challenging given its nonspecific presentation and limited diagnostic modalities. Therefore, patients continually exposed to endemic areas should prompt more frequent diagnostic re-evaluation prior to Infliximab escalation." @default.
• W3209573214 created "2021-11-08" @default.
• W3209573214 creator A5024520597 @default.
• W3209573214 creator A5043106502 @default.
• W3209573214 creator A5056695438 @default.
• W3209573214 date "2021-10-01" @default.
• W3209573214 modified "2023-09-23" @default.
• W3209573214 title "S2456 TB or Not TB? Miliary Tuberculosis in a QuantiFERON-Indeterminate Patient on Infliximab Therapy" @default.
• W3209573214 doi "https://doi.org/10.14309/01.ajg.0000783356.87046.9c" @default.
• W3209573214 hasPublicationYear "2021" @default.
• W3209573214 type Work @default.
• W3209573214 sameAs 3209573214 @default.
• W3209573214 citedByCount "0" @default.
• W3209573214 crossrefType "journal-article" @default.
• W3209573214 hasAuthorship W3209573214A5024520597 @default.
• W3209573214 hasAuthorship W3209573214A5043106502 @default.
• W3209573214 hasAuthorship W3209573214A5056695438 @default.
• W3209573214 hasBestOaLocation W32095732141 @default.
• W3209573214 hasConcept C126322002 @default.
• W3209573214 hasConcept C141071460 @default.
• W3209573214 hasConcept C142724271 @default.
• W3209573214 hasConcept C16005928 @default.
• W3209573214 hasConcept C2776228421 @default.
• W3209573214 hasConcept C2776763545 @default.
• W3209573214 hasConcept C2777138892 @default.
• W3209573214 hasConcept C2777975735 @default.
• W3209573214 hasConcept C2778329809 @default.
• W3209573214 hasConcept C2779134260 @default.
• W3209573214 hasConcept C2779806340 @default.
• W3209573214 hasConcept C2781069245 @default.
• W3209573214 hasConcept C71924100 @default.
• W3209573214 hasConcept C90924648 @default.
• W3209573214 hasConceptScore W3209573214C126322002 @default.
• W3209573214 hasConceptScore W3209573214C141071460 @default.
• W3209573214 hasConceptScore W3209573214C142724271 @default.
• W3209573214 hasConceptScore W3209573214C16005928 @default.
• W3209573214 hasConceptScore W3209573214C2776228421 @default.
• W3209573214 hasConceptScore W3209573214C2776763545 @default.
• W3209573214 hasConceptScore W3209573214C2777138892 @default.
• W3209573214 hasConceptScore W3209573214C2777975735 @default.
• W3209573214 hasConceptScore W3209573214C2778329809 @default.
• W3209573214 hasConceptScore W3209573214C2779134260 @default.
• W3209573214 hasConceptScore W3209573214C2779806340 @default.
• W3209573214 hasConceptScore W3209573214C2781069245 @default.
• W3209573214 hasConceptScore W3209573214C71924100 @default.
• W3209573214 hasConceptScore W3209573214C90924648 @default.
• W3209573214 hasIssue "1" @default.
• W3209573214 hasLocation W32095732141 @default.
• W3209573214 hasLocation W32095732142 @default.
• W3209573214 hasOpenAccess W3209573214 @default.
• W3209573214 hasPrimaryLocation W32095732141 @default.
• W3209573214 hasRelatedWork W13777425 @default.
• W3209573214 hasRelatedWork W1995459579 @default.
• W3209573214 hasRelatedWork W2058168006 @default.
• W3209573214 hasRelatedWork W2101470941 @default.
• W3209573214 hasRelatedWork W2118252327 @default.
• W3209573214 hasRelatedWork W2154239844 @default.
• W3209573214 hasRelatedWork W2443276129 @default.
• W3209573214 hasRelatedWork W2604543294 @default.
• W3209573214 hasRelatedWork W2956353651 @default.
• W3209573214 hasRelatedWork W3119823993 @default.
• W3209573214 hasVolume "116" @default.
• W3209573214 isParatext "false" @default.
• W3209573214 isRetracted "false" @default.
• W3209573214 magId "3209573214" @default.
• W3209573214 workType "article" @default.