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- W3209585462 abstract "Abstract Background Growing evidence suggests that vascular risk factors, especially hypertension, relate not only to cardiovascular disease but also to cognitive impairment. However, the impact of pulse pressure on cognitive function remains controversial. In this study, we evaluated the associations between pulse pressure and cognitive function in a Japanese health examination cohort using propensity matching analysis. Methods We examined 2,546 individuals with a mean age of 60.8 ± 10.3 years who voluntarily participated in health examination. Clinical variables including pulse pressure, brain magnetic resonance imaging (MRI), and cognitive function were assessed. We divided the participants into the high and low pulse pressure groups and evaluated their physical examination data, cognitive functions, and silent brain lesions using propensity matching. To clarify whether pulse pressure and blood pressure have different implications for cognitive function, a mediating analysis was also conducted. Results Higher pulse pressure corresponded to lower Okabe and Kohs’ scores. The relationship between pulse pressure and cognitive impairment was not significantly mediated by systolic blood pressure. We observed no significant associations between silent brain lesions and pulse pressure. Conclusion High pulse pressure associates with cognitive impairment without systolic blood pressure mediation in Japanese subjects without dementia." @default.
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- W3209585462 date "2021-10-25" @default.
- W3209585462 modified "2023-09-26" @default.
- W3209585462 title "Pulse Pressure is Associated with Cognitive Impairment in Japanese Non-Demented Population: A Cross-Sectional Study" @default.
- W3209585462 doi "https://doi.org/10.21203/rs.3.rs-991138/v1" @default.
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