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- W3209613510 abstract "The bone extracellular matrix (ECM) contains organic and mineral constituents. The establishment and degradation processes of ECM connect with spatial and temporal patterns, especially circadian rhythms in ECM. These patterns are responsible for the physical and biological characteristics of bone. The disturbances of the patterns disrupt bone matrix remodeling and cause diverse bone diseases, such as osteogenesis imperfecta (OI) and bone fracture. In addition, the main regulatory factors and inflammatory factors also follow circadian rhythms. Studies show that the circadian oscillations of these factors in bone ECM potentially influence the interactions between immune responses and bone formation. More importantly, mesenchymal stem cells (MSCs) within the specific microenvironments provide the regenerative potential for tissue remodeling. In this review, we summarize the advanced ECM spatial characteristics and the periodic patterns of bone ECM. Importantly, we focus on the intrinsic connections between the immunoinflammatory system and bone formation according to circadian rhythms of regulatory factors in bone ECM. And our research group emphasizes the multipotency of MSCs with their microenvironments. The advanced understandings of bone ECM formation patterns and MSCs contribute to providing optimal prevention and treatment strategies." @default.
- W3209613510 created "2021-11-08" @default.
- W3209613510 creator A5001897189 @default.
- W3209613510 creator A5007181965 @default.
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- W3209613510 creator A5055211283 @default.
- W3209613510 creator A5058073103 @default.
- W3209613510 creator A5085884522 @default.
- W3209613510 date "2021-11-03" @default.
- W3209613510 modified "2023-10-14" @default.
- W3209613510 title "Spatial-Temporal Patterns and Inflammatory Factors of Bone Matrix Remodeling" @default.
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