FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3209622270> ?p ?o ?g. }

• W3209622270 endingPage "11535" @default.
• W3209622270 startingPage "11535" @default.
• W3209622270 abstract "Tissue remodeling contributes to ongoing inflammation and refractoriness of chronic rhinosinusitis (CRS). During this process, epithelial-mesenchymal transition (EMT) plays an important role in dysregulated remodeling and both microRNA (miR)-29b and heat shock protein 47 (HSP47) may be engaged in the pathophysiology of CRS. This study aimed to determine the role of miR-29b and HSP47 in modulating transforming growth factor (TGF)-β1-induced EMT and migration in airway epithelial cells. Expression levels of miR-29b, HSP47, E-cadherin, α-smooth muscle actin (α-SMA), vimentin and fibronectin were assessed through real-time PCR, Western blotting, and immunofluorescence staining. Small interfering RNA (siRNA) targeted against miR-29b and HSP47 were transfected to regulate the expression of EMT-related markers. Cell migration was evaluated with wound scratch and transwell migration assay. miR-29b mimic significantly inhibited the expression of HSP47 and TGF-β1-induced EMT-related markers in A549 cells. However, the miR-29b inhibitor more greatly induced the expression of them. HSP47 knockout suppressed TGF-β1-induced EMT marker levels. Functional studies indicated that TGF-β1-induced EMT was regulated by miR-29b and HSP47 in A549 cells. These findings were further verified in primary nasal epithelial cells. miR-29b modulated TGF-β1-induced EMT-related markers and migration via HSP47 expression modulation in A549 and primary nasal epithelial cells. These results suggested the importance of miR-29b and HSP47 in pathologic tissue remodeling progression in CRS." @default.
• W3209622270 created "2021-11-08" @default.
• W3209622270 creator A5038844360 @default.
• W3209622270 creator A5070739086 @default.
• W3209622270 creator A5076458741 @default.
• W3209622270 creator A5080619272 @default.
• W3209622270 creator A5085324516 @default.
• W3209622270 creator A5091044411 @default.
• W3209622270 date "2021-10-26" @default.
• W3209622270 modified "2023-10-12" @default.
• W3209622270 title "miR-29b Regulates TGF-β1-Induced Epithelial–Mesenchymal Transition by Inhibiting Heat Shock Protein 47 Expression in Airway Epithelial Cells" @default.
• W3209622270 cites W1945572218 @default.
• W3209622270 cites W1978596588 @default.
• W3209622270 cites W2025894943 @default.
• W3209622270 cites W2028251585 @default.
• W3209622270 cites W2055740721 @default.
• W3209622270 cites W2067989180 @default.
• W3209622270 cites W2087158191 @default.
• W3209622270 cites W2120169383 @default.
• W3209622270 cites W2135580384 @default.
• W3209622270 cites W2163169932 @default.
• W3209622270 cites W2298907915 @default.
• W3209622270 cites W2324178939 @default.
• W3209622270 cites W2364897480 @default.
• W3209622270 cites W2472286572 @default.
• W3209622270 cites W2549531463 @default.
• W3209622270 cites W2607403768 @default.
• W3209622270 cites W2775629330 @default.
• W3209622270 cites W2900294366 @default.
• W3209622270 cites W2937230843 @default.
• W3209622270 cites W2982497935 @default.
• W3209622270 cites W3000151357 @default.
• W3209622270 cites W3045417094 @default.
• W3209622270 cites W3046391563 @default.
• W3209622270 cites W3083472235 @default.
• W3209622270 cites W3111670355 @default.
• W3209622270 cites W3123306882 @default.
• W3209622270 cites W2991169943 @default.
• W3209622270 doi "https://doi.org/10.3390/ijms222111535" @default.
• W3209622270 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8584188" @default.
• W3209622270 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34768968" @default.
• W3209622270 hasPublicationYear "2021" @default.
• W3209622270 type Work @default.
• W3209622270 sameAs 3209622270 @default.
• W3209622270 citedByCount "3" @default.
• W3209622270 countsByYear W32096222702023 @default.
• W3209622270 crossrefType "journal-article" @default.
• W3209622270 hasAuthorship W3209622270A5038844360 @default.
• W3209622270 hasAuthorship W3209622270A5070739086 @default.
• W3209622270 hasAuthorship W3209622270A5076458741 @default.
• W3209622270 hasAuthorship W3209622270A5080619272 @default.
• W3209622270 hasAuthorship W3209622270A5085324516 @default.
• W3209622270 hasAuthorship W3209622270A5091044411 @default.
• W3209622270 hasBestOaLocation W32096222701 @default.
• W3209622270 hasConcept C104317684 @default.
• W3209622270 hasConcept C127561419 @default.
• W3209622270 hasConcept C137738243 @default.
• W3209622270 hasConcept C142724271 @default.
• W3209622270 hasConcept C147447768 @default.
• W3209622270 hasConcept C1491633281 @default.
• W3209622270 hasConcept C189165786 @default.
• W3209622270 hasConcept C203014093 @default.
• W3209622270 hasConcept C204232928 @default.
• W3209622270 hasConcept C22615655 @default.
• W3209622270 hasConcept C502942594 @default.
• W3209622270 hasConcept C54009773 @default.
• W3209622270 hasConcept C54355233 @default.
• W3209622270 hasConcept C55493867 @default.
• W3209622270 hasConcept C71924100 @default.
• W3209622270 hasConcept C76419328 @default.
• W3209622270 hasConcept C81729549 @default.
• W3209622270 hasConcept C81885089 @default.
• W3209622270 hasConcept C86492073 @default.
• W3209622270 hasConcept C86803240 @default.
• W3209622270 hasConcept C95444343 @default.
• W3209622270 hasConceptScore W3209622270C104317684 @default.
• W3209622270 hasConceptScore W3209622270C127561419 @default.
• W3209622270 hasConceptScore W3209622270C137738243 @default.
• W3209622270 hasConceptScore W3209622270C142724271 @default.
• W3209622270 hasConceptScore W3209622270C147447768 @default.
• W3209622270 hasConceptScore W3209622270C1491633281 @default.
• W3209622270 hasConceptScore W3209622270C189165786 @default.
• W3209622270 hasConceptScore W3209622270C203014093 @default.
• W3209622270 hasConceptScore W3209622270C204232928 @default.
• W3209622270 hasConceptScore W3209622270C22615655 @default.
• W3209622270 hasConceptScore W3209622270C502942594 @default.
• W3209622270 hasConceptScore W3209622270C54009773 @default.
• W3209622270 hasConceptScore W3209622270C54355233 @default.
• W3209622270 hasConceptScore W3209622270C55493867 @default.
• W3209622270 hasConceptScore W3209622270C71924100 @default.
• W3209622270 hasConceptScore W3209622270C76419328 @default.
• W3209622270 hasConceptScore W3209622270C81729549 @default.
• W3209622270 hasConceptScore W3209622270C81885089 @default.
• W3209622270 hasConceptScore W3209622270C86492073 @default.
• W3209622270 hasConceptScore W3209622270C86803240 @default.
• W3209622270 hasConceptScore W3209622270C95444343 @default.
• W3209622270 hasFunder F4320322120 @default.
• W3209622270 hasIssue "21" @default.

• next