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• W3209656321 abstract "Disordered chromatin remodeling regulation has emerged as an essential driving factor for cancers. Imitation switch (ISWI) family are evolutionarily conserved ATP-dependent chromatin remodeling complexes, which are essential for cellular survival and function through multiple genetic and epigenetic mechanisms. Omics sequencing and a growing number of basic and clinical studies found that ISWI family members displayed widespread gene expression and genetic status abnormalities in human cancer. Their aberrant expression is closely linked to patient outcome and drug response. Functional or componential alteration in ISWI-containing complexes is critical for tumor initiation and development. Furthermore, ISWI-non-coding RNA regulatory networks and some non-coding RNAs derived from exons of ISWI member genes play important roles in tumor progression. Therefore, unveiling the transcriptional regulation mechanism underlying ISWI family sparked a booming interest in finding ISWI-based therapies in cancer. This review aims at describing the current state-of-the-art in the role of ISWI subunits and complexes in tumorigenesis, tumor progression, immunity and drug response, and presenting deep insight into the physiological and pathological implications of the ISWI transcription machinery in cancers." @default.
• W3209656321 created "2021-11-08" @default.
• W3209656321 creator A5013555971 @default.
• W3209656321 creator A5013795174 @default.
• W3209656321 creator A5033747658 @default.
• W3209656321 creator A5035282947 @default.
• W3209656321 creator A5038202726 @default.
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• W3209656321 creator A5071777836 @default.
• W3209656321 creator A5076763078 @default.
• W3209656321 creator A5091100665 @default.
• W3209656321 date "2021-11-04" @default.
• W3209656321 modified "2023-10-14" @default.
• W3209656321 title "The emerging role of ISWI chromatin remodeling complexes in cancer" @default.
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