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• W3209692649 abstract "Abstract Background COVID-19 symptoms range from mild to severe illness; the cause for this differential response to infection remains unknown. Unravelling the immune mechanisms acting at different levels of the colonization process might be key to understand these differences. Methods and findings We carried out a multi-tissue (nasal, buccal and blood; n = 156) gene expression analysis of immune-related genes from patients affected by different COVID-19 severities, and healthy controls through the nCounter technology. We then used a differential expression approach and pathways analysis to detect tissue specific immune severity signals in COVID-19 patients. Mild and asymptomatic cases showed a powerful innate antiviral response in nasal epithelium, characterized by activation of interferon (IFN) pathway and downstream cascades, successfully controlling the infection at local level. In contrast, weak macrophage/monocyte driven innate antiviral response and lack of IFN signalling activity were shown in severe cases. Consequently, oral mucosa from severe patients showed signals of viral activity, cell arresting and viral dissemination to the lower respiratory tract, which ultimately could explain the exacerbated innate immune response and impaired adaptative immune responses observed at systemic level. Results from saliva transcriptome suggest that the buccal cavity might play a key role in SARS-CoV-2 infection and dissemination in patients with worse prognosis. Conclusions We found severity-related signatures in patient tissues mainly represented by genes involved in the innate immune system and cytokine/chemokine signalling. Local immune response could be key to determine the course of the systemic response and thus COVID-19 severity. Our findings provide a framework to investigate severity host gene biomarkers and pathways that might be relevant to diagnosis, prognosis, and therapy." @default.
• W3209692649 created "2021-11-08" @default.
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• W3209692649 date "2021-10-29" @default.
• W3209692649 modified "2023-10-16" @default.
• W3209692649 title "A multi-tissue study of immune gene expression profiling highlights the key role of the nasal epithelium in COVID-19 severity" @default.
• W3209692649 cites W1577577364 @default.
• W3209692649 cites W1969957411 @default.
• W3209692649 cites W1985987855 @default.
• W3209692649 cites W1994915168 @default.
• W3209692649 cites W1997651223 @default.
• W3209692649 cites W2016749309 @default.
• W3209692649 cites W2023674649 @default.
• W3209692649 cites W2035618305 @default.
• W3209692649 cites W2037466316 @default.
• W3209692649 cites W2039521726 @default.
• W3209692649 cites W2106608030 @default.
• W3209692649 cites W2110547512 @default.
• W3209692649 cites W2114805242 @default.
• W3209692649 cites W2118310160 @default.
• W3209692649 cites W2130410032 @default.
• W3209692649 cites W2131200439 @default.
• W3209692649 cites W2146512944 @default.
• W3209692649 cites W2146743474 @default.
• W3209692649 cites W2148708580 @default.
• W3209692649 cites W2167523852 @default.
• W3209692649 cites W2179438025 @default.
• W3209692649 cites W2216485355 @default.
• W3209692649 cites W2406250479 @default.
• W3209692649 cites W2474277182 @default.
• W3209692649 cites W2514928018 @default.
• W3209692649 cites W2517204460 @default.
• W3209692649 cites W2739638175 @default.
• W3209692649 cites W2765744828 @default.
• W3209692649 cites W2780398602 @default.
• W3209692649 cites W2784906428 @default.
• W3209692649 cites W2786793629 @default.
• W3209692649 cites W2800845333 @default.
• W3209692649 cites W2803981123 @default.
• W3209692649 cites W2942610007 @default.
• W3209692649 cites W2955848963 @default.
• W3209692649 cites W2977313709 @default.
• W3209692649 cites W3001118548 @default.
• W3209692649 cites W3005187171 @default.
• W3209692649 cites W3005690553 @default.
• W3209692649 cites W3006961006 @default.
• W3209692649 cites W3008090866 @default.
• W3209692649 cites W3009859788 @default.
• W3209692649 cites W3011483298 @default.
• W3209692649 cites W3011812996 @default.
• W3209692649 cites W3013270782 @default.
• W3209692649 cites W3013449264 @default.
• W3209692649 cites W3013616922 @default.
• W3209692649 cites W3014006087 @default.
• W3209692649 cites W3014050022 @default.
• W3209692649 cites W3014663601 @default.
• W3209692649 cites W3015429491 @default.
• W3209692649 cites W3018221920 @default.
• W3209692649 cites W3020425489 @default.
• W3209692649 cites W3020909574 @default.
• W3209692649 cites W3021242766 @default.
• W3209692649 cites W3023982717 @default.
• W3209692649 cites W3035423175 @default.
• W3209692649 cites W3036869070 @default.
• W3209692649 cites W3036882010 @default.
• W3209692649 cites W3037544553 @default.
• W3209692649 cites W3041479264 @default.
• W3209692649 cites W3041960835 @default.
• W3209692649 cites W3042075747 @default.
• W3209692649 cites W3045188041 @default.
• W3209692649 cites W3046231656 @default.
• W3209692649 cites W3062126634 @default.
• W3209692649 cites W3080652759 @default.
• W3209692649 cites W3081687852 @default.
• W3209692649 cites W3082684881 @default.
• W3209692649 cites W3084149299 @default.
• W3209692649 cites W3085718285 @default.
• W3209692649 cites W3085801799 @default.
• W3209692649 cites W3085958090 @default.
• W3209692649 cites W3091902939 @default.
• W3209692649 cites W3093413235 @default.
• W3209692649 cites W3094282922 @default.

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