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- W3209714898 abstract "Abstract Microglia contribute to Alzheimer’s Disease (AD) progression and are candidate therapeutic targets. Human microglia exhibit an array of transcriptional phenotypes implying that accurate manipulation of microglial function will require clarity of their molecular states and context dependent regulation. To increase the number of microglia analyzed per subject we employed fluorescence activated nuclei sorting prior to single-nucleus RNA-seq on human prefrontal cortices. We observed microglia phenotypes previously unrecognized in human brain gene expression studies and mapped their transcriptomic relationships by trajectory inference. Three clusters were enriched for endolysosomal pathways, one of which showed differential expression of AD GWAS genes in addition to genes implicated in nucleic acid detection and interferon signaling. Analysis of the “homeostatic” microglia cluster revealed a uniquely AD subcluster. Our study demonstrates the value of deeply profiling microglia to explore the biological implications of microglia transcriptomic diversity." @default.
- W3209714898 created "2021-11-08" @default.
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- W3209714898 date "2021-10-26" @default.
- W3209714898 modified "2023-10-12" @default.
- W3209714898 title "Transcriptomically unique endolysosomal and homeostatic microglia populations in Alzheimer’s disease and aged human brain" @default.
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- W3209714898 doi "https://doi.org/10.1101/2021.10.25.465802" @default.
- W3209714898 hasPublicationYear "2021" @default.
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