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• W3209728890 abstract "Abstract Background Multiple sclerosis (MS) is a chronic autoimmune disease driven by sustained inflammation in the central nervous system. One of the pathological hallmarks of MS is extensive free radical production. However, the subsequent generation, potential pathological role, and detoxification of different lipid peroxidation-derived reactive carbonyl species during neuroinflammation are unclear, as are the therapeutic benefits of carbonyl quenchers. Here, we investigated the reactive carbonyl acrolein and (the therapeutic effect of) acrolein quenching by carnosine during neuroinflammation. Methods The abundance and localization of acrolein was investigated in inflammatory lesions of MS patients and experimental autoimmune encephalomyelitis (EAE) mice. In addition, we analysed carnosine levels and acrolein quenching by endogenous and exogenous carnosine in EAE. Finally, the therapeutic effect of exogenous carnosine was assessed in vivo (EAE) and in vitro (primary mouse microglia, macrophages, astrocytes). Results Acrolein was substantially increased in inflammatory lesions of MS patients and EAE mice. Levels of the dipeptide carnosine (β-alanyl- l -histidine), an endogenous carbonyl quencher particularly reactive towards acrolein, and the carnosine-acrolein adduct (carnosine-propanal) were ~ twofold lower within EAE spinal cord tissue. Oral carnosine treatment augmented spinal cord carnosine levels (up to > tenfold), increased carnosine-acrolein quenching, reduced acrolein-protein adduct formation, suppressed inflammatory activity, and alleviated clinical disease severity in EAE. In vivo and in vitro studies indicate that pro-inflammatory microglia/macrophages generate acrolein, which can be efficiently quenched by increasing carnosine availability, resulting in suppressed inflammatory activity. Other properties of carnosine (antioxidant, nitric oxide scavenging) may also contribute to the therapeutic effects. Conclusions Our results identify carbonyl (particularly acrolein) quenching by carnosine as a therapeutic strategy to counter inflammation and macromolecular damage in MS." @default.
• W3209728890 created "2021-11-08" @default.
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• W3209728890 date "2021-11-05" @default.
• W3209728890 modified "2023-10-13" @default.
• W3209728890 title "Carnosine quenches the reactive carbonyl acrolein in the central nervous system and attenuates autoimmune neuroinflammation" @default.
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• W3209728890 cites W1536744532 @default.
• W3209728890 cites W1552434751 @default.
• W3209728890 cites W1577577364 @default.
• W3209728890 cites W1607206274 @default.
• W3209728890 cites W1828576284 @default.
• W3209728890 cites W1934811695 @default.
• W3209728890 cites W1964665990 @default.
• W3209728890 cites W1967505225 @default.
• W3209728890 cites W1970796396 @default.
• W3209728890 cites W1973362554 @default.
• W3209728890 cites W1975914508 @default.
• W3209728890 cites W1978715967 @default.
• W3209728890 cites W1984704805 @default.
• W3209728890 cites W1997372166 @default.
• W3209728890 cites W2008231587 @default.
• W3209728890 cites W2010097555 @default.
• W3209728890 cites W2017930303 @default.
• W3209728890 cites W2019022238 @default.
• W3209728890 cites W2023725391 @default.
• W3209728890 cites W2024140382 @default.
• W3209728890 cites W2054275187 @default.
• W3209728890 cites W2057522312 @default.
• W3209728890 cites W2059552759 @default.
• W3209728890 cites W2084909523 @default.
• W3209728890 cites W2090777067 @default.
• W3209728890 cites W2095580717 @default.
• W3209728890 cites W2099562613 @default.
• W3209728890 cites W2111370164 @default.
• W3209728890 cites W2112408314 @default.
• W3209728890 cites W2120773936 @default.
• W3209728890 cites W2137356761 @default.
• W3209728890 cites W2138121094 @default.
• W3209728890 cites W2191292005 @default.
• W3209728890 cites W2282981307 @default.
• W3209728890 cites W2285460017 @default.
• W3209728890 cites W2321399883 @default.
• W3209728890 cites W2469273189 @default.
• W3209728890 cites W2510179449 @default.
• W3209728890 cites W2519162342 @default.
• W3209728890 cites W2549644306 @default.
• W3209728890 cites W2562977489 @default.
• W3209728890 cites W2563039951 @default.
• W3209728890 cites W2586966505 @default.
• W3209728890 cites W2600168059 @default.
• W3209728890 cites W2613045394 @default.
• W3209728890 cites W2749337106 @default.
• W3209728890 cites W2765218802 @default.
• W3209728890 cites W2773675887 @default.
• W3209728890 cites W2784431956 @default.
• W3209728890 cites W2786316997 @default.
• W3209728890 cites W2786318872 @default.
• W3209728890 cites W2788933778 @default.
• W3209728890 cites W2801312164 @default.
• W3209728890 cites W2804198722 @default.
• W3209728890 cites W2885927965 @default.
• W3209728890 cites W2890125882 @default.
• W3209728890 cites W2897312192 @default.
• W3209728890 cites W2897773126 @default.
• W3209728890 cites W2900574893 @default.
• W3209728890 cites W2911725378 @default.
• W3209728890 cites W2949693884 @default.
• W3209728890 cites W2955092445 @default.
• W3209728890 cites W2985192224 @default.
• W3209728890 cites W3008508106 @default.
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• W3209728890 doi "https://doi.org/10.1186/s12974-021-02306-9" @default.
• W3209728890 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8571880" @default.
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• W3209728890 hasPublicationYear "2021" @default.
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