Matches in SemOpenAlex for { <https://semopenalex.org/work/W3209747954> ?p ?o ?g. }
- W3209747954 abstract "Increasing evidence suggests that in vitro fertilization (IVF) may be associated with an increased risk of developing obesity and metabolic diseases later in life in the offspring. Notably, the addition of melatonin to culture medium may improve embryo development and prevent cardiovascular dysfunction in IVF adult mice. This study aimed to determine if melatonin supplementation in the culture medium can reverse impaired glucose metabolism in IVF mice offspring and the underlying mechanisms. Blastocysts used for transfer were generated by natural mating (control group) or IVF with or without melatonin (10-6 M) supplementation (mIVF and IVF group, respectively) in clinical-grade culture media. Here, we first report that IVF decreased hepatic expression of Fbxl7, which was associated with impaired glucose metabolism in mice offspring. Melatonin addition reversed the phenotype by up-regulating the expression of hepatic Fbxl7. In vitro experiments showed that Fbxl7 enhanced the insulin signaling pathway by degrading RhoA through ubiquitination and was up-regulated by transcription factor Foxa2. Specific knockout of Fbxl7 in the liver of adult mice, through tail intravenous injection of recombinant adeno-associated virus, impaired glucose tolerance, while overexpression of hepatic Fbxl7 significantly improved glucose tolerance in adult IVF mice. Thus, the data suggest that Fbxl7 plays an important role in maintaining glucose metabolism of mice, and melatonin supplementation in the culture medium may rescue the long-term risk of metabolic diseases in IVF offspring." @default.
- W3209747954 created "2021-11-08" @default.
- W3209747954 creator A5008540359 @default.
- W3209747954 creator A5009826802 @default.
- W3209747954 creator A5010383775 @default.
- W3209747954 creator A5013186280 @default.
- W3209747954 creator A5016297609 @default.
- W3209747954 creator A5017178504 @default.
- W3209747954 creator A5028881152 @default.
- W3209747954 creator A5033020983 @default.
- W3209747954 creator A5057834550 @default.
- W3209747954 creator A5058603003 @default.
- W3209747954 creator A5063110312 @default.
- W3209747954 creator A5076478503 @default.
- W3209747954 creator A5087302456 @default.
- W3209747954 creator A5089439223 @default.
- W3209747954 creator A5090920925 @default.
- W3209747954 date "2021-12-03" @default.
- W3209747954 modified "2023-10-14" @default.
- W3209747954 title "Melatonin supplementation in the culture medium rescues impaired glucose metabolism in IVF mice offspring" @default.
- W3209747954 cites W1716810435 @default.
- W3209747954 cites W1844312938 @default.
- W3209747954 cites W1964031474 @default.
- W3209747954 cites W1970792890 @default.
- W3209747954 cites W1975169884 @default.
- W3209747954 cites W1978089688 @default.
- W3209747954 cites W1979055428 @default.
- W3209747954 cites W1982818510 @default.
- W3209747954 cites W1994919529 @default.
- W3209747954 cites W1997741476 @default.
- W3209747954 cites W2001405008 @default.
- W3209747954 cites W2001813843 @default.
- W3209747954 cites W2016754212 @default.
- W3209747954 cites W2028067695 @default.
- W3209747954 cites W2028966545 @default.
- W3209747954 cites W2029356978 @default.
- W3209747954 cites W2040017622 @default.
- W3209747954 cites W2045283564 @default.
- W3209747954 cites W2055092042 @default.
- W3209747954 cites W2062501347 @default.
- W3209747954 cites W2066020526 @default.
- W3209747954 cites W2075202597 @default.
- W3209747954 cites W2087199631 @default.
- W3209747954 cites W2096531574 @default.
- W3209747954 cites W2096612144 @default.
- W3209747954 cites W2099560343 @default.
- W3209747954 cites W2115208391 @default.
- W3209747954 cites W2129434699 @default.
- W3209747954 cites W2143847855 @default.
- W3209747954 cites W2145591214 @default.
- W3209747954 cites W2147545348 @default.
- W3209747954 cites W2150408168 @default.
- W3209747954 cites W2158068037 @default.
- W3209747954 cites W2165543359 @default.
- W3209747954 cites W2183199504 @default.
- W3209747954 cites W2216710583 @default.
- W3209747954 cites W2238308167 @default.
- W3209747954 cites W2254262262 @default.
- W3209747954 cites W2276507574 @default.
- W3209747954 cites W2289042320 @default.
- W3209747954 cites W2302504690 @default.
- W3209747954 cites W2560125023 @default.
- W3209747954 cites W2587368411 @default.
- W3209747954 cites W2606728662 @default.
- W3209747954 cites W2728715382 @default.
- W3209747954 cites W2767467045 @default.
- W3209747954 cites W2772801538 @default.
- W3209747954 cites W2792065479 @default.
- W3209747954 cites W2809505601 @default.
- W3209747954 cites W2884347422 @default.
- W3209747954 cites W2901740709 @default.
- W3209747954 cites W2905440802 @default.
- W3209747954 cites W2907063341 @default.
- W3209747954 cites W2911348880 @default.
- W3209747954 cites W2913162405 @default.
- W3209747954 cites W2914352735 @default.
- W3209747954 cites W2915563981 @default.
- W3209747954 cites W2925599397 @default.
- W3209747954 cites W2959814266 @default.
- W3209747954 cites W2965299749 @default.
- W3209747954 cites W2965745841 @default.
- W3209747954 cites W2973564248 @default.
- W3209747954 cites W2980934775 @default.
- W3209747954 cites W2985432310 @default.
- W3209747954 cites W3005110232 @default.
- W3209747954 cites W3006902664 @default.
- W3209747954 cites W3008081750 @default.
- W3209747954 cites W3010013908 @default.
- W3209747954 cites W3013029453 @default.
- W3209747954 cites W3013068423 @default.
- W3209747954 cites W3090886449 @default.
- W3209747954 cites W3095285782 @default.
- W3209747954 cites W3107038103 @default.
- W3209747954 cites W3108752949 @default.
- W3209747954 cites W3111370788 @default.
- W3209747954 cites W4231894124 @default.
- W3209747954 doi "https://doi.org/10.1111/jpi.12778" @default.
- W3209747954 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34726796" @default.
- W3209747954 hasPublicationYear "2021" @default.
- W3209747954 type Work @default.