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• W3209771402 abstract "70%-84% of individuals with antipsychotic treatment resistance show non-response from the first episode. Emerging cross-sectional evidence comparing cognitive profiles in treatment resistant schizophrenia to treatment-responsive schizophrenia has indicated that verbal memory and language functions may be more impaired in treatment resistance. We sought to confirm this finding by comparing cognitive performance between antipsychotic non-responders (NR) and responders (R) using a brief cognitive battery for schizophrenia, with a primary focus on verbal tasks compared against other measures of cognition.Cross-sectional.This cross-sectional study recruited antipsychotic treatment R and antipsychotic NR across four UK sites. Cognitive performance was assessed using the Brief Assessment of Cognition in Schizophrenia (BACS).One hundred and six participants aged 18-65 years with a diagnosis of schizophrenia or schizophreniform disorder were recruited according to their treatment response, with 52 NR and 54 R cases.Composite and subscale scores of cognitive performance on the BACS. Group (R vs NR) differences in cognitive scores were investigated using univariable and multivariable linear regressions adjusted for age, gender and illness duration.Univariable regression models observed no significant differences between R and NR groups on any measure of the BACS, including verbal memory (ß=-1.99, 95% CI -6.63 to 2.66, p=0.398) and verbal fluency (ß=1.23, 95% CI -2.46 to 4.91, p=0.510). This pattern of findings was consistent in multivariable models.The lack of group difference in cognition in our sample is likely due to a lack of clinical distinction between our groups. Future investigations should aim to use machine learning methods using longitudinal first episode samples to identify responder subtypes within schizophrenia, and how cognitive factors may interact within this.REC: 15/LO/0038." @default.
• W3209771402 created "2021-11-08" @default.
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• W3209771402 date "2021-11-01" @default.
• W3209771402 modified "2023-10-17" @default.
• W3209771402 title "Cross-sectional study comparing cognitive function in treatment responsive versus treatment non-responsive schizophrenia: evidence from the STRATA study" @default.
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• W3209771402 cites W1970372026 @default.
• W3209771402 cites W1986425967 @default.
• W3209771402 cites W1987834520 @default.
• W3209771402 cites W1995051494 @default.
• W3209771402 cites W2000383686 @default.
• W3209771402 cites W2001822785 @default.
• W3209771402 cites W2005342508 @default.
• W3209771402 cites W2008062633 @default.
• W3209771402 cites W2013230963 @default.
• W3209771402 cites W2018927895 @default.
• W3209771402 cites W2021356749 @default.
• W3209771402 cites W2024078112 @default.
• W3209771402 cites W2032517670 @default.
• W3209771402 cites W2047205137 @default.
• W3209771402 cites W2049335636 @default.
• W3209771402 cites W2059669521 @default.
• W3209771402 cites W2059717138 @default.
• W3209771402 cites W2069418962 @default.
• W3209771402 cites W2071340370 @default.
• W3209771402 cites W2075718175 @default.
• W3209771402 cites W2076339227 @default.
• W3209771402 cites W2078717479 @default.
• W3209771402 cites W2082074499 @default.
• W3209771402 cites W2091561736 @default.
• W3209771402 cites W2096544065 @default.
• W3209771402 cites W2099240715 @default.
• W3209771402 cites W2111698739 @default.
• W3209771402 cites W2119409164 @default.
• W3209771402 cites W2119922117 @default.
• W3209771402 cites W2140606211 @default.
• W3209771402 cites W2143776947 @default.
• W3209771402 cites W2148772507 @default.
• W3209771402 cites W2149451815 @default.
• W3209771402 cites W2151137320 @default.
• W3209771402 cites W2154091436 @default.
• W3209771402 cites W2160235820 @default.
• W3209771402 cites W2172100505 @default.
• W3209771402 cites W2175366611 @default.
• W3209771402 cites W2280484203 @default.
• W3209771402 cites W2335471937 @default.
• W3209771402 cites W2414437245 @default.
• W3209771402 cites W2469715053 @default.
• W3209771402 cites W2517254183 @default.
• W3209771402 cites W2552106994 @default.
• W3209771402 cites W2577123768 @default.
• W3209771402 cites W2578041951 @default.
• W3209771402 cites W2580516220 @default.
• W3209771402 cites W2605692276 @default.
• W3209771402 cites W2605982210 @default.
• W3209771402 cites W2612727556 @default.
• W3209771402 cites W2622372453 @default.
• W3209771402 cites W2889181835 @default.
• W3209771402 cites W2896749562 @default.
• W3209771402 cites W2904941108 @default.
• W3209771402 cites W2912254966 @default.
• W3209771402 cites W2916543729 @default.
• W3209771402 cites W2918793347 @default.
• W3209771402 cites W2945575042 @default.
• W3209771402 cites W2954450251 @default.
• W3209771402 cites W2955772992 @default.
• W3209771402 cites W2969616952 @default.
• W3209771402 cites W3006100854 @default.
• W3209771402 cites W3011624175 @default.
• W3209771402 cites W3023762651 @default.
• W3209771402 cites W3027463619 @default.
• W3209771402 cites W3040903862 @default.
• W3209771402 cites W3086533835 @default.
• W3209771402 cites W3091977258 @default.
• W3209771402 cites W3133199303 @default.
• W3209771402 cites W3171418018 @default.
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• W3209771402 doi "https://doi.org/10.1136/bmjopen-2021-054160" @default.
• W3209771402 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34824121" @default.
• W3209771402 hasPublicationYear "2021" @default.

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