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• W3209800903 endingPage "102873" @default.
• W3209800903 startingPage "102873" @default.
• W3209800903 abstract "Degeneration of the locus coeruleus (LC) is recognized as a critical hallmark of Parkinson's disease (PD). Recent studies have reported that noradrenaline produced from the LC has critical effects on brain functional organization. However, it is unknown if LC degeneration in PD contributes to cognitive/motor manifestations through modulating brain functional organization. This study enrolled 94 PD patients and 68 healthy controls, and LC integrity was measured using the contrast-to-noise ratio of the LC (CNRLC) calculated from T1-weighted magnetic resonance imaging. We used graph-theory-based network analysis to characterize brain functional organization. The relationships among LC degeneration, network disruption, and cognitive/motor manifestations in PD were assessed. Whether network disruption was a mediator between LC degeneration and cognitive/motor impairments was assessed further. In addition, an independent PD subgroup (n = 35) having functional magnetic resonance scanning before and after levodopa administration was enrolled to evaluate whether LC degeneration-related network deficiencies were independent of dopamine deficiency. We demonstrated that PD patients have significant LC degeneration compared to healthy controls. CNRLC was positively correlated with Montreal Cognitive Assessment score and the nodal efficiency (NE) of several cognitive-related regions. Lower NE of the superior temporal gyrus was a mediator between LC degeneration and cognitive impairment in PD. However, levodopa treatment could not normalize the reduced NE of the superior temporal gyrus (mediator). In conclusion, we provided evidence for the relationship between LC degeneration and extensive network disruption in PD, and highlight the role of network disorganization in LC degeneration-related cognitive impairment." @default.
• W3209800903 created "2021-11-08" @default.
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• W3209800903 date "2021-01-01" @default.
• W3209800903 modified "2023-10-01" @default.
• W3209800903 title "Locus coeruleus degeneration is associated with disorganized functional topology in Parkinson’s disease" @default.
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• W3209800903 doi "https://doi.org/10.1016/j.nicl.2021.102873" @default.
• W3209800903 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8578042" @default.
• W3209800903 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34749290" @default.
• W3209800903 hasPublicationYear "2021" @default.
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