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- W3209801373 abstract "We developed a 4D interplay effect model to quantitatively evaluate breathing-induced interplay effects and assess the feasibility of utilizing spot-scanning proton arc (SPArc) therapy for hypo-fractionated lung stereotactic body radiotherapy (SBRT). The model was then validated by retrospective application to clinical cases.A digital lung 4DCT phantoms was used to mimic targets in diameter of 3cm with breathing motion amplitudes: 5, 10, 15, and 20 mm, respectively. Two planning groups based on robust optimization were generated: (1) Two-field Intensity Modulated Proton Therapy (IMPT) plans and (2) SPArc plans via a partial arc. 5000 cGy was prescribed to the internal target volume (ITV) in 5 fractions. To quantitatively assess the breathing induced interplay effect, the 4D dynamic dose was calculated by synchronizing the breathing pattern with the simulated proton machine delivery sequence, including IMPT, Volumetric repainting (IMPTvolumetric), iso-layered repainting (IMPTlayer) and SPArc. Ten lung patients' 4DCT previously treated with VMAT SBRT, were used to validate the digital lung tumor model. Normal tissue complicated probability (NTCP) of chestwall toxicity was calculated.Target dose were degraded as the tumor motion amplitude increased. The 4D interplay effect phantom model indicated that motion mitigation effectiveness using SPArc was about five times of IMPTvolumetric or IMPTlayer using maximum MU/spot as 0.5 MU at 20 mm motion amplitude. The retrospective study showed that SPArc has an advantage in normal tissue sparing. The probability of chestwall's toxicity were significantly improved from 40.2% ± 29.0% (VMAT) (P = 0.01) and 16.3% ± 12.0% (IMPT) (P = 0.01) to 10.1% ± 5.4% (SPArc). SPArc significantly mitigated the interplay effect compared to IMPT, where the average target D99 in single fraction 4D dynamic dose throughout patients was 4876 ± 107 cGy[RBE] (IMPT) vs. 4913 ± 64 cGy[RBE] (SPArc) (P < 0.01).SPArc is an efficient treatment modality capable of effectively mitigating the interplay effect in lung SBRT compared to IMPT with repainting. Such a technique has the potential to further reduce the normal tissue complexity compared to the VMAT.G. Liu: None. L. Zhao: None. A. Qin: None. R.L. Deraniyagala: None. C.W. Stevens: None. D. Yan: None. X. Li: None. X. Ding: None." @default.
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- W3209801373 date "2021-11-01" @default.
- W3209801373 modified "2023-09-23" @default.
- W3209801373 title "Lung Stereotactic Body Radiotherapy (SBRT) Using Spot-Scanning Proton Arc (SPArc) Therapy: A Feasibility Study" @default.
- W3209801373 doi "https://doi.org/10.1016/j.ijrobp.2021.07.1488" @default.
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