Matches in SemOpenAlex for { <https://semopenalex.org/work/W3209812653> ?p ?o ?g. }
- W3209812653 abstract "Over the past years, peptides have attracted increasing interest for G protein-coupled receptor (GPCR) drug discovery and development. Peptides occupy a unique chemical space that is not easily accessible for small molecules and antibodies and provide advantages over these ligand classes such as lower toxicity and higher selectivity. The κ-opioid receptor (KOR) is a prototypic GPCR and an appealing therapeutic target for the development of safer and more effective analgesics. Recently, peptides have emerged as analgesic drug candidates with improved side effect profiles. We have previously identified plant-derived peptides, which activate KOR. Based on this precedent, here we relied on publicly available databases to discover novel KOR peptide ligands by genome mining. Using human preprodynorphin as a query, we identified blenny fish-derived peptides, referred to as blenniorphins, capable of binding to and activating KOR with nanomolar affinity and potency, respectively. Additionally, the blenniorphins altered β-arrestin-2 recruitment at the KOR. Our study demonstrates the utility of genome mining to identify peptide GPCR ligands with intriguing pharmacological properties and unveils the potential of blenny fishes as a source for novel KOR ligands." @default.
- W3209812653 created "2021-11-08" @default.
- W3209812653 creator A5005511726 @default.
- W3209812653 creator A5008037495 @default.
- W3209812653 creator A5029045654 @default.
- W3209812653 creator A5049100399 @default.
- W3209812653 creator A5060360807 @default.
- W3209812653 creator A5072063000 @default.
- W3209812653 date "2021-10-22" @default.
- W3209812653 modified "2023-09-23" @default.
- W3209812653 title "Genome Mining-Based Discovery of Blenny Fish-Derived Peptides Targeting the Mouse κ-Opioid Receptor" @default.
- W3209812653 cites W1541516368 @default.
- W3209812653 cites W1543236252 @default.
- W3209812653 cites W1567081863 @default.
- W3209812653 cites W1970407380 @default.
- W3209812653 cites W1994656998 @default.
- W3209812653 cites W2003207203 @default.
- W3209812653 cites W2010531200 @default.
- W3209812653 cites W2021733207 @default.
- W3209812653 cites W2028645925 @default.
- W3209812653 cites W2070098194 @default.
- W3209812653 cites W2074599713 @default.
- W3209812653 cites W2076323933 @default.
- W3209812653 cites W2084719431 @default.
- W3209812653 cites W2090055657 @default.
- W3209812653 cites W2110566477 @default.
- W3209812653 cites W2125425115 @default.
- W3209812653 cites W2147196684 @default.
- W3209812653 cites W2177786495 @default.
- W3209812653 cites W2312582369 @default.
- W3209812653 cites W2557809815 @default.
- W3209812653 cites W2561058767 @default.
- W3209812653 cites W2579679755 @default.
- W3209812653 cites W2584604256 @default.
- W3209812653 cites W2617279801 @default.
- W3209812653 cites W2765153686 @default.
- W3209812653 cites W2800926943 @default.
- W3209812653 cites W2803572653 @default.
- W3209812653 cites W2808792445 @default.
- W3209812653 cites W2884887849 @default.
- W3209812653 cites W2890283911 @default.
- W3209812653 cites W2902898515 @default.
- W3209812653 cites W2909204744 @default.
- W3209812653 cites W2929883728 @default.
- W3209812653 cites W2946386518 @default.
- W3209812653 cites W2980479257 @default.
- W3209812653 cites W2995337781 @default.
- W3209812653 cites W3001942526 @default.
- W3209812653 cites W3006232652 @default.
- W3209812653 cites W3015123576 @default.
- W3209812653 cites W3041369629 @default.
- W3209812653 cites W3046472620 @default.
- W3209812653 cites W3093777800 @default.
- W3209812653 cites W3119952098 @default.
- W3209812653 cites W3127297964 @default.
- W3209812653 cites W3145340769 @default.
- W3209812653 cites W3177241996 @default.
- W3209812653 doi "https://doi.org/10.3389/fphar.2021.773029" @default.
- W3209812653 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8569185" @default.
- W3209812653 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34744752" @default.
- W3209812653 hasPublicationYear "2021" @default.
- W3209812653 type Work @default.
- W3209812653 sameAs 3209812653 @default.
- W3209812653 citedByCount "1" @default.
- W3209812653 countsByYear W32098126532023 @default.
- W3209812653 crossrefType "journal-article" @default.
- W3209812653 hasAuthorship W3209812653A5005511726 @default.
- W3209812653 hasAuthorship W3209812653A5008037495 @default.
- W3209812653 hasAuthorship W3209812653A5029045654 @default.
- W3209812653 hasAuthorship W3209812653A5049100399 @default.
- W3209812653 hasAuthorship W3209812653A5060360807 @default.
- W3209812653 hasAuthorship W3209812653A5072063000 @default.
- W3209812653 hasBestOaLocation W32098126531 @default.
- W3209812653 hasConcept C104317684 @default.
- W3209812653 hasConcept C135285700 @default.
- W3209812653 hasConcept C141231307 @default.
- W3209812653 hasConcept C170493617 @default.
- W3209812653 hasConcept C185592680 @default.
- W3209812653 hasConcept C2779281246 @default.
- W3209812653 hasConcept C2779886867 @default.
- W3209812653 hasConcept C2781063702 @default.
- W3209812653 hasConcept C55493867 @default.
- W3209812653 hasConcept C60644358 @default.
- W3209812653 hasConcept C70721500 @default.
- W3209812653 hasConcept C74187038 @default.
- W3209812653 hasConcept C86803240 @default.
- W3209812653 hasConceptScore W3209812653C104317684 @default.
- W3209812653 hasConceptScore W3209812653C135285700 @default.
- W3209812653 hasConceptScore W3209812653C141231307 @default.
- W3209812653 hasConceptScore W3209812653C170493617 @default.
- W3209812653 hasConceptScore W3209812653C185592680 @default.
- W3209812653 hasConceptScore W3209812653C2779281246 @default.
- W3209812653 hasConceptScore W3209812653C2779886867 @default.
- W3209812653 hasConceptScore W3209812653C2781063702 @default.
- W3209812653 hasConceptScore W3209812653C55493867 @default.
- W3209812653 hasConceptScore W3209812653C60644358 @default.
- W3209812653 hasConceptScore W3209812653C70721500 @default.
- W3209812653 hasConceptScore W3209812653C74187038 @default.
- W3209812653 hasConceptScore W3209812653C86803240 @default.
- W3209812653 hasFunder F4320321181 @default.