Matches in SemOpenAlex for { <https://semopenalex.org/work/W3209812964> ?p ?o ?g. }
Showing items 1 to 70 of
70
with 100 items per page.
- W3209812964 endingPage "S1381" @default.
- W3209812964 startingPage "S1381" @default.
- W3209812964 abstract "Introduction: Immune checkpoint inhibitor-mediated colitis (IMC) is a common adverse event following immune checkpoint inhibitor (ICI) therapy for cancer. IMC has been associated with improved overall survival (OS) and progression-free survival (PFS), but data are limited to a single site and predominantly for melanoma patients. We sought to determine the association of IMC with OS and PFS and identify clinical predictors of IMC. Methods: We performed a retrospective case-control study including 64 ICI users who developed IMC matched according to age, sex, ICI class, and malignancy to a cohort of ICI users without IMC. We collected data on clinical characteristics and progression-free survival in both cohorts. Using univariate and multivariate logistic regression, we determined association of presence of IMC on OS, PFS, and clinical predictors of IMC. Kaplan-Meier curves were generated to compare OS and PFS between ICI users with and without IMC. Results: IMC was significantly associated with a higher OS (mean 24.3 months versus 17.7, p = 0.05) but not PFS (mean 13.7 months versus 11.9, p = 0.524). IMC was significantly associated with OS greater than 12 months (Odds ratio [OR] 2.81, 95% confidence interval [CI] 1.17-6.77). Vitamin D supplementation was significantly associated with increased risk of IMC (OR 2.48, 95% CI 1.01-6.07). Conclusion: IMC was significantly associated with improved OS and with OS greater than 12 months. In contrast to prior work, we found that vitamin D use may be a risk factor for IMC.Figure 1.: Kaplan-Meier curves of overall and progression-free survival in patients with and without IMC. A) Overall survival in patients with and without IMC. B) Progression-free survival in patients with and without IMC. IMC, immune checkpoint inhibitor-mediated colitis. HR, hazard ratio. CI, confidence interval.Table 1.: Univariate and Multivariate Predictors of IMC Among Patients Using ICI (N=128)." @default.
- W3209812964 created "2021-11-08" @default.
- W3209812964 creator A5019899805 @default.
- W3209812964 creator A5022065132 @default.
- W3209812964 creator A5046030411 @default.
- W3209812964 creator A5066409584 @default.
- W3209812964 creator A5067999767 @default.
- W3209812964 creator A5079913102 @default.
- W3209812964 date "2021-10-01" @default.
- W3209812964 modified "2023-09-23" @default.
- W3209812964 title "S3352 Immune Checkpoint Inhibitor-Mediated Colitis Is Associated With Improved Cancer Overall Survival" @default.
- W3209812964 doi "https://doi.org/10.14309/01.ajg.0000786940.40773.e6" @default.
- W3209812964 hasPublicationYear "2021" @default.
- W3209812964 type Work @default.
- W3209812964 sameAs 3209812964 @default.
- W3209812964 citedByCount "0" @default.
- W3209812964 crossrefType "journal-article" @default.
- W3209812964 hasAuthorship W3209812964A5019899805 @default.
- W3209812964 hasAuthorship W3209812964A5022065132 @default.
- W3209812964 hasAuthorship W3209812964A5046030411 @default.
- W3209812964 hasAuthorship W3209812964A5066409584 @default.
- W3209812964 hasAuthorship W3209812964A5067999767 @default.
- W3209812964 hasAuthorship W3209812964A5079913102 @default.
- W3209812964 hasBestOaLocation W32098129641 @default.
- W3209812964 hasConcept C121608353 @default.
- W3209812964 hasConcept C126322002 @default.
- W3209812964 hasConcept C143998085 @default.
- W3209812964 hasConcept C156957248 @default.
- W3209812964 hasConcept C197934379 @default.
- W3209812964 hasConcept C2776694085 @default.
- W3209812964 hasConcept C2780739268 @default.
- W3209812964 hasConcept C44249647 @default.
- W3209812964 hasConcept C50382708 @default.
- W3209812964 hasConcept C71924100 @default.
- W3209812964 hasConcept C72563966 @default.
- W3209812964 hasConcept C90924648 @default.
- W3209812964 hasConceptScore W3209812964C121608353 @default.
- W3209812964 hasConceptScore W3209812964C126322002 @default.
- W3209812964 hasConceptScore W3209812964C143998085 @default.
- W3209812964 hasConceptScore W3209812964C156957248 @default.
- W3209812964 hasConceptScore W3209812964C197934379 @default.
- W3209812964 hasConceptScore W3209812964C2776694085 @default.
- W3209812964 hasConceptScore W3209812964C2780739268 @default.
- W3209812964 hasConceptScore W3209812964C44249647 @default.
- W3209812964 hasConceptScore W3209812964C50382708 @default.
- W3209812964 hasConceptScore W3209812964C71924100 @default.
- W3209812964 hasConceptScore W3209812964C72563966 @default.
- W3209812964 hasConceptScore W3209812964C90924648 @default.
- W3209812964 hasIssue "1" @default.
- W3209812964 hasLocation W32098129641 @default.
- W3209812964 hasLocation W32098129642 @default.
- W3209812964 hasOpenAccess W3209812964 @default.
- W3209812964 hasPrimaryLocation W32098129641 @default.
- W3209812964 hasRelatedWork W1766946880 @default.
- W3209812964 hasRelatedWork W1973855633 @default.
- W3209812964 hasRelatedWork W1998259048 @default.
- W3209812964 hasRelatedWork W2317313649 @default.
- W3209812964 hasRelatedWork W4205334046 @default.
- W3209812964 hasRelatedWork W4304808194 @default.
- W3209812964 hasRelatedWork W4311192294 @default.
- W3209812964 hasRelatedWork W4327920375 @default.
- W3209812964 hasRelatedWork W4382585466 @default.
- W3209812964 hasRelatedWork W4385856392 @default.
- W3209812964 hasVolume "116" @default.
- W3209812964 isParatext "false" @default.
- W3209812964 isRetracted "false" @default.
- W3209812964 magId "3209812964" @default.
- W3209812964 workType "article" @default.