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- W3209843883 abstract "Here we show the development of heterobifunctional small molecules capable of selectively targeting MCL1 using a Proteolysis Targeting Chimera (PROTAC) methodology leading to successful degradation. We have confirmed the involvement of the E3 ligase CUL4A-DDB1 cereblon (CRBN) ubiquitination pathway, making these PROTACs a first step toward a new class of anti-apoptotic BCL-2 family protein degraders." @default.
- W3209843883 created "2021-11-08" @default.
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- W3209843883 date "2019-02-15" @default.
- W3209843883 modified "2023-10-17" @default.
- W3209843883 title "From Inhibition to Degradation: Targeting the Anti-apoptotic Protein Myeloid Cell Leukemia 1(MCL1)" @default.
- W3209843883 doi "https://doi.org/10.26434/chemrxiv.7722359.v1" @default.
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