Matches in SemOpenAlex for { <https://semopenalex.org/work/W3209858602> ?p ?o ?g. }
- W3209858602 abstract "Fish species, such as zebrafish (Danio rerio), can regenerate their appendages after amputation through the formation of a heterogeneous cellular structure named blastema. Here, by combining live imaging of triple transgenic zebrafish embryos and single-cell RNA sequencing we established a detailed cell atlas of the regenerating caudal fin in zebrafish larvae. We confirmed the presence of macrophage subsets that govern zebrafish fin regeneration, and identified a foxd3-positive cell population within the regenerating fin. Genetic depletion of these foxd3-positive neural crest-derived cells (NCdC) showed that they are involved in blastema formation and caudal fin regeneration. Finally, chemical inhibition and transcriptomic analysis demonstrated that these foxd3-positive cells regulate macrophage recruitment and polarization through the NRG1/ErbB pathway. Here, we show the diversity of the cells required for blastema formation, identify a discrete foxd3-positive NCdC population, and reveal the critical function of the NRG1/ErbB pathway in controlling the dialogue between macrophages and NCdC." @default.
- W3209858602 created "2021-11-08" @default.
- W3209858602 creator A5003210314 @default.
- W3209858602 creator A5004343368 @default.
- W3209858602 creator A5009581879 @default.
- W3209858602 creator A5025907859 @default.
- W3209858602 creator A5044106964 @default.
- W3209858602 creator A5044428408 @default.
- W3209858602 creator A5051689782 @default.
- W3209858602 creator A5051711255 @default.
- W3209858602 creator A5058103666 @default.
- W3209858602 creator A5069087828 @default.
- W3209858602 creator A5069841702 @default.
- W3209858602 creator A5084525465 @default.
- W3209858602 date "2021-11-03" @default.
- W3209858602 modified "2023-10-17" @default.
- W3209858602 title "NRG1/ErbB signalling controls the dialogue between macrophages and neural crest-derived cells during zebrafish fin regeneration" @default.
- W3209858602 cites W1549792523 @default.
- W3209858602 cites W1908290270 @default.
- W3209858602 cites W1966987683 @default.
- W3209858602 cites W1967959203 @default.
- W3209858602 cites W1969644508 @default.
- W3209858602 cites W1980916535 @default.
- W3209858602 cites W1981692093 @default.
- W3209858602 cites W1988564150 @default.
- W3209858602 cites W1992663358 @default.
- W3209858602 cites W1995138630 @default.
- W3209858602 cites W2020788680 @default.
- W3209858602 cites W2024470896 @default.
- W3209858602 cites W2025903846 @default.
- W3209858602 cites W2028157008 @default.
- W3209858602 cites W2029416405 @default.
- W3209858602 cites W2030890903 @default.
- W3209858602 cites W2040653604 @default.
- W3209858602 cites W2043648485 @default.
- W3209858602 cites W2048003465 @default.
- W3209858602 cites W2050195517 @default.
- W3209858602 cites W2063671952 @default.
- W3209858602 cites W2064140933 @default.
- W3209858602 cites W2070515279 @default.
- W3209858602 cites W2070734183 @default.
- W3209858602 cites W2075935381 @default.
- W3209858602 cites W2095059099 @default.
- W3209858602 cites W2100388117 @default.
- W3209858602 cites W2115844415 @default.
- W3209858602 cites W2120231073 @default.
- W3209858602 cites W2120676127 @default.
- W3209858602 cites W2121195205 @default.
- W3209858602 cites W2124875294 @default.
- W3209858602 cites W2127925349 @default.
- W3209858602 cites W2150761291 @default.
- W3209858602 cites W2152663152 @default.
- W3209858602 cites W2155490506 @default.
- W3209858602 cites W2156420692 @default.
- W3209858602 cites W2165389148 @default.
- W3209858602 cites W2166884973 @default.
- W3209858602 cites W2167279371 @default.
- W3209858602 cites W2170811625 @default.
- W3209858602 cites W2333893582 @default.
- W3209858602 cites W2464410938 @default.
- W3209858602 cites W2550675068 @default.
- W3209858602 cites W2743154979 @default.
- W3209858602 cites W2892640601 @default.
- W3209858602 cites W2902071445 @default.
- W3209858602 cites W2966060504 @default.
- W3209858602 cites W2981938374 @default.
- W3209858602 cites W2995700709 @default.
- W3209858602 cites W2998632984 @default.
- W3209858602 cites W2999300780 @default.
- W3209858602 cites W3007171906 @default.
- W3209858602 cites W3043815129 @default.
- W3209858602 cites W3048434310 @default.
- W3209858602 cites W3081691131 @default.
- W3209858602 cites W7354718 @default.
- W3209858602 doi "https://doi.org/10.1038/s41467-021-26422-5" @default.
- W3209858602 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8566576" @default.
- W3209858602 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34732706" @default.
- W3209858602 hasPublicationYear "2021" @default.
- W3209858602 type Work @default.
- W3209858602 sameAs 3209858602 @default.
- W3209858602 citedByCount "7" @default.
- W3209858602 countsByYear W32098586022022 @default.
- W3209858602 countsByYear W32098586022023 @default.
- W3209858602 crossrefType "journal-article" @default.
- W3209858602 hasAuthorship W3209858602A5003210314 @default.
- W3209858602 hasAuthorship W3209858602A5004343368 @default.
- W3209858602 hasAuthorship W3209858602A5009581879 @default.
- W3209858602 hasAuthorship W3209858602A5025907859 @default.
- W3209858602 hasAuthorship W3209858602A5044106964 @default.
- W3209858602 hasAuthorship W3209858602A5044428408 @default.
- W3209858602 hasAuthorship W3209858602A5051689782 @default.
- W3209858602 hasAuthorship W3209858602A5051711255 @default.
- W3209858602 hasAuthorship W3209858602A5058103666 @default.
- W3209858602 hasAuthorship W3209858602A5069087828 @default.
- W3209858602 hasAuthorship W3209858602A5069841702 @default.
- W3209858602 hasAuthorship W3209858602A5084525465 @default.
- W3209858602 hasBestOaLocation W32098586021 @default.
- W3209858602 hasConcept C104317684 @default.
- W3209858602 hasConcept C105702510 @default.
- W3209858602 hasConcept C126749454 @default.