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- W3209881615 abstract "AstraZeneca's covid-19 vaccine demonstrates some concerns regarding its excipients, such as polysorbate 80, which serves as a stabilizer, and EDTA, which serves as a binding agent. 7 ADA is a critical purine metabolic enzyme required for adequate immunological competence. The current study examines the effect of Zn2+ on the maintenance of ADA. After eliminating Zn2+, the protein's crystallographic structure has retained a high degree of order and similarity to the original one, with some alterations limited to the areas surrounding the pocket. However, the protein's stability has been dramatically reduced. EDTA is a highly effective zinc-chelating agent employed in the investigations of protein interactions. The potential damage of the structure and interactions of zinc-binding proteins by EDTA treatment must be considered. Excess Zn2+ has not returned C/H1 to its normal structure, highlighting the irreversible denaturation induced by the EDTA. Around 30% of proteins in cells form complexes with metals. Metal ions are essential not just for regulating biological functions but also for stabilizing proteins. (ADA, EC 3.5.4.4) has a molecular mass of 40 kDa and contains a firmly attached zinc ion essential for its activity. The lack of its enzymatic activity leads to malfunction B and T cells, and SCID development" @default.
- W3209881615 created "2021-11-08" @default.
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- W3209881615 date "2021-10-24" @default.
- W3209881615 modified "2023-09-26" @default.
- W3209881615 title "Are babies of vaccinated Pregnant and lactating mothers with ChAdOx1 AstraZeneca covid vaccine more risk for zinc deficiency and SCID disease." @default.
- W3209881615 doi "https://doi.org/10.14293/s2199-1006.1.sor-.pp3sfae.v1" @default.
- W3209881615 hasPublicationYear "2021" @default.
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