Matches in SemOpenAlex for { <https://semopenalex.org/work/W3209884929> ?p ?o ?g. }
- W3209884929 abstract "Skeletal muscles display sexually dimorphic features. Biochemically, glycolysis and fatty acid β-oxidation occur preferentially in the muscles of males and females, respectively. However, the mechanisms of the selective utilization of these fuels remains elusive. Here, we obtain transcriptomes from quadriceps type IIB fibers of untreated, gonadectomized, and sex steroid-treated mice of both sexes. Analyses of the transcriptomes unveil two genes, Pfkfb3 (phosphofructokinase-2) and Pdk4 (pyruvate dehydrogenase kinase 4), that may function as switches between the two sexually dimorphic metabolic pathways. Interestingly, Pfkfb3 and Pdk4 show male-enriched and estradiol-enhanced expression, respectively. Moreover, the contribution of these genes to sexually dimorphic metabolism is demonstrated by knockdown studies with cultured type IIB muscle fibers. Considering that skeletal muscles as a whole are the largest energy-consuming organs, our results provide insights into energy metabolism in the two sexes, during the estrus cycle in women, and under pathological conditions involving skeletal muscles." @default.
- W3209884929 created "2021-11-08" @default.
- W3209884929 creator A5015480428 @default.
- W3209884929 creator A5033023750 @default.
- W3209884929 creator A5040297828 @default.
- W3209884929 creator A5044109189 @default.
- W3209884929 creator A5063649274 @default.
- W3209884929 creator A5081961761 @default.
- W3209884929 creator A5087195498 @default.
- W3209884929 creator A5087832785 @default.
- W3209884929 creator A5089583817 @default.
- W3209884929 date "2021-11-04" @default.
- W3209884929 modified "2023-10-16" @default.
- W3209884929 title "Sex differences in metabolic pathways are regulated by Pfkfb3 and Pdk4 expression in rodent muscle" @default.
- W3209884929 cites W1498886216 @default.
- W3209884929 cites W1512881602 @default.
- W3209884929 cites W1535070605 @default.
- W3209884929 cites W1763983382 @default.
- W3209884929 cites W1885970184 @default.
- W3209884929 cites W1919512980 @default.
- W3209884929 cites W1941910566 @default.
- W3209884929 cites W1960002717 @default.
- W3209884929 cites W1967360036 @default.
- W3209884929 cites W1974053532 @default.
- W3209884929 cites W1974894157 @default.
- W3209884929 cites W1976792745 @default.
- W3209884929 cites W1978661176 @default.
- W3209884929 cites W1981868769 @default.
- W3209884929 cites W1989760304 @default.
- W3209884929 cites W1995576474 @default.
- W3209884929 cites W1996704658 @default.
- W3209884929 cites W2003330837 @default.
- W3209884929 cites W2011173742 @default.
- W3209884929 cites W2014185583 @default.
- W3209884929 cites W2028908433 @default.
- W3209884929 cites W2030700564 @default.
- W3209884929 cites W2035540931 @default.
- W3209884929 cites W2036753725 @default.
- W3209884929 cites W2043054174 @default.
- W3209884929 cites W2043209502 @default.
- W3209884929 cites W2045611938 @default.
- W3209884929 cites W2057559671 @default.
- W3209884929 cites W2066537398 @default.
- W3209884929 cites W2067594063 @default.
- W3209884929 cites W2068269175 @default.
- W3209884929 cites W2071622413 @default.
- W3209884929 cites W2072263024 @default.
- W3209884929 cites W2079121632 @default.
- W3209884929 cites W2080407205 @default.
- W3209884929 cites W2087051284 @default.
- W3209884929 cites W2091403555 @default.
- W3209884929 cites W2094053629 @default.
- W3209884929 cites W2094746410 @default.
- W3209884929 cites W2097561994 @default.
- W3209884929 cites W2098072804 @default.
- W3209884929 cites W2099148164 @default.
- W3209884929 cites W2114589445 @default.
- W3209884929 cites W2119647215 @default.
- W3209884929 cites W2124407637 @default.
- W3209884929 cites W2130025116 @default.
- W3209884929 cites W2138207763 @default.
- W3209884929 cites W2142084131 @default.
- W3209884929 cites W2151445988 @default.
- W3209884929 cites W2159005026 @default.
- W3209884929 cites W2162459586 @default.
- W3209884929 cites W2167279371 @default.
- W3209884929 cites W2167344472 @default.
- W3209884929 cites W2167740392 @default.
- W3209884929 cites W2168299884 @default.
- W3209884929 cites W2169456326 @default.
- W3209884929 cites W2237575183 @default.
- W3209884929 cites W2319360889 @default.
- W3209884929 cites W2326676506 @default.
- W3209884929 cites W2335813013 @default.
- W3209884929 cites W2465560519 @default.
- W3209884929 cites W2549027334 @default.
- W3209884929 cites W2610777581 @default.
- W3209884929 cites W2766313885 @default.
- W3209884929 cites W2784734859 @default.
- W3209884929 cites W2886239325 @default.
- W3209884929 cites W2887427759 @default.
- W3209884929 cites W2919279123 @default.
- W3209884929 cites W2945494553 @default.
- W3209884929 cites W2950902413 @default.
- W3209884929 cites W2963618058 @default.
- W3209884929 cites W2971287565 @default.
- W3209884929 cites W2998666372 @default.
- W3209884929 cites W3002380642 @default.
- W3209884929 cites W3037120109 @default.
- W3209884929 cites W3138241978 @default.
- W3209884929 cites W4210953210 @default.
- W3209884929 doi "https://doi.org/10.1038/s42003-021-02790-y" @default.
- W3209884929 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8569015" @default.
- W3209884929 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34737380" @default.
- W3209884929 hasPublicationYear "2021" @default.
- W3209884929 type Work @default.
- W3209884929 sameAs 3209884929 @default.
- W3209884929 citedByCount "5" @default.
- W3209884929 countsByYear W32098849292022 @default.
- W3209884929 countsByYear W32098849292023 @default.