Matches in SemOpenAlex for { <https://semopenalex.org/work/W3209892019> ?p ?o ?g. }
- W3209892019 endingPage "3455" @default.
- W3209892019 startingPage "3440" @default.
- W3209892019 abstract "Clinically relevant myopenia accompanies spinal cord injury (SCI), and compromises function, metabolism, body composition, and health. Myostatin, a transforming growth factor (TGF)β family member, is a key negative regulator of skeletal muscle mass. We investigated inhibition of myostatin signaling using systemic delivery of a highly selective monoclonal antibody - muSRK-015P (40 mg/kg) - that blocks release of active growth factor from the latent form of myostatin. Adult female mice (C57BL/6) were subjected to a severe SCI (65 kdyn) at T9 and were then immediately and 1 week later administered test articles: muSRK-015P (40 mg/kg) or control (vehicle or IgG). A sham control group (laminectomy only) was included. At euthanasia, (2 weeks post-SCI) muSRK-015P preserved whole body lean mass and sublesional gastrocnemius and soleus mass. muSRK-015P-treated mice with SCI also had significantly attenuated myofiber atrophy, lipid infiltration, and loss of slow-oxidative phenotype in soleus muscle. These outcomes were accompanied by significantly improved sublesional motor function and muscle force production at 1 and 2 weeks post-SCI. At 2 weeks post-SCI, lean mass was significantly decreased in SCI-IgG mice, but was not different in SCI-muSRK-015P mice than in sham controls. Total energy expenditure (kCal/day) at 2 weeks post-SCI was lower in SCI-immunoglobulin (Ig)G mice, but not different in SCI-muSRK-015P mice than in sham controls. We conclude that in a randomized, blinded, and controlled study in mice, myostatin inhibition using muSRK-015P had broad effects on physical, metabolic, and functional outcomes when compared with IgG control treated SCI animals. These findings may identify a useful, targeted therapeutic strategy for treating post-SCI myopenia and related sequelae in humans." @default.
- W3209892019 created "2021-11-08" @default.
- W3209892019 creator A5009309290 @default.
- W3209892019 creator A5011373172 @default.
- W3209892019 creator A5027559430 @default.
- W3209892019 creator A5038391715 @default.
- W3209892019 creator A5053311946 @default.
- W3209892019 date "2021-12-15" @default.
- W3209892019 modified "2023-09-26" @default.
- W3209892019 title "Selective Myostatin Inhibition Spares Sublesional Muscle Mass and Myopenia-Related Dysfunction after Severe Spinal Cord Contusion in Mice" @default.
- W3209892019 cites W1458217 @default.
- W3209892019 cites W1489102529 @default.
- W3209892019 cites W1571718655 @default.
- W3209892019 cites W1659002779 @default.
- W3209892019 cites W1748379224 @default.
- W3209892019 cites W1820228121 @default.
- W3209892019 cites W1955609192 @default.
- W3209892019 cites W1964417136 @default.
- W3209892019 cites W1967321749 @default.
- W3209892019 cites W1967465122 @default.
- W3209892019 cites W1967619991 @default.
- W3209892019 cites W1969705877 @default.
- W3209892019 cites W1971809291 @default.
- W3209892019 cites W1972604813 @default.
- W3209892019 cites W1972641070 @default.
- W3209892019 cites W1973842058 @default.
- W3209892019 cites W1974626477 @default.
- W3209892019 cites W1978177347 @default.
- W3209892019 cites W1979057337 @default.
- W3209892019 cites W1979397290 @default.
- W3209892019 cites W1979942439 @default.
- W3209892019 cites W1983325630 @default.
- W3209892019 cites W1983415262 @default.
- W3209892019 cites W1985477058 @default.
- W3209892019 cites W1989888013 @default.
- W3209892019 cites W1991129063 @default.
- W3209892019 cites W1992162034 @default.
- W3209892019 cites W1994261229 @default.
- W3209892019 cites W1994270208 @default.
- W3209892019 cites W1998631080 @default.
- W3209892019 cites W2000059256 @default.
- W3209892019 cites W2002631725 @default.
- W3209892019 cites W2004810821 @default.
- W3209892019 cites W2005080823 @default.
- W3209892019 cites W2011466202 @default.
- W3209892019 cites W2014899456 @default.
- W3209892019 cites W2027667550 @default.
- W3209892019 cites W2028026223 @default.
- W3209892019 cites W2028966038 @default.
- W3209892019 cites W2029591368 @default.
- W3209892019 cites W2030301571 @default.
- W3209892019 cites W2033991878 @default.
- W3209892019 cites W2035223341 @default.
- W3209892019 cites W2039328837 @default.
- W3209892019 cites W2040871722 @default.
- W3209892019 cites W2041742077 @default.
- W3209892019 cites W2041811148 @default.
- W3209892019 cites W2045333877 @default.
- W3209892019 cites W2047259732 @default.
- W3209892019 cites W2053079324 @default.
- W3209892019 cites W2054368198 @default.
- W3209892019 cites W2054919722 @default.
- W3209892019 cites W2056656068 @default.
- W3209892019 cites W2057148677 @default.
- W3209892019 cites W2057338072 @default.
- W3209892019 cites W2060575247 @default.
- W3209892019 cites W2074161753 @default.
- W3209892019 cites W2080583960 @default.
- W3209892019 cites W2085098316 @default.
- W3209892019 cites W2090221386 @default.
- W3209892019 cites W2093294273 @default.
- W3209892019 cites W2095606469 @default.
- W3209892019 cites W2099540110 @default.
- W3209892019 cites W2102107385 @default.
- W3209892019 cites W2102638170 @default.
- W3209892019 cites W2104321619 @default.
- W3209892019 cites W2108604696 @default.
- W3209892019 cites W2108708765 @default.
- W3209892019 cites W2108720133 @default.
- W3209892019 cites W2109168446 @default.
- W3209892019 cites W2113551891 @default.
- W3209892019 cites W2114725982 @default.
- W3209892019 cites W2114952053 @default.
- W3209892019 cites W2117267014 @default.
- W3209892019 cites W2118149354 @default.
- W3209892019 cites W2119333938 @default.
- W3209892019 cites W2120813098 @default.
- W3209892019 cites W2122554400 @default.
- W3209892019 cites W2125061065 @default.
- W3209892019 cites W2129063712 @default.
- W3209892019 cites W2129228740 @default.
- W3209892019 cites W2133828201 @default.
- W3209892019 cites W2145592650 @default.
- W3209892019 cites W2146923536 @default.
- W3209892019 cites W2149075623 @default.
- W3209892019 cites W2151283204 @default.
- W3209892019 cites W2152101348 @default.
- W3209892019 cites W2153029800 @default.