FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3209938416> ?p ?o ?g. }

• W3209938416 abstract "Hepatic ischemia/reperfusion (I/R) injury (HIRI) often occurs following tissue resection, hemorrhagic shock or transplantation surgery. Previous investigations showed that sevoflurane (Sevo), an inhalation anesthetic, had protective properties against different organ damage in animal models including HIRI. This study is aimed to investigate the underlying mechanisms involved in the protective effects of Sevo on HIRI. The present study results showed that treatment with Sevo improved histologic damage, inflammatory response, oxidative stress and apoptosis after hepatic I/R, indicating the protective role of Sevo against liver I/R injury. Importantly, in order to determine the molecular mechanism of Sevo in HIRI, the focus of the study was on microRNA (miR) regulation. By retrieving the microarray data in the Gene Expression Omnibus dataset (GSE72315), miR‑218‑5p was found to be significantly downregulated by Sevo. Moreover, miR‑218‑5p overexpression using agomiR‑218‑5p reversed the protective roles of Sevo against HIRI. Furthermore, GAB2, a positive regulator of PI3K/AKT signaling pathway, was found as a target gene of miR‑218‑5p. It was also found that the Sevo‑mediated protective effects may be dependent on the activation of GAB2/PI3K/AKT. Collectively, these data revealed that Sevo alleviated HIRI in mice by restraining apoptosis, relieving oxidative stress and inflammatory response through the miR‑218‑5p/GAB2/PI3K/AKT pathway, which helps in understanding the novel mechanism of the hepatic‑protection of Sevo." @default.
• W3209938416 created "2021-11-08" @default.
• W3209938416 creator A5035221303 @default.
• W3209938416 creator A5035590977 @default.
• W3209938416 creator A5065859286 @default.
• W3209938416 creator A5070134243 @default.
• W3209938416 date "2021-11-01" @default.
• W3209938416 modified "2023-10-17" @default.
• W3209938416 title "Role of microRNA‑218‑5p in sevoflurane‑induced protective effects in hepatic ischemia/reperfusion injury mice by regulating GAB2/PI3K/AKT pathway" @default.
• W3209938416 cites W144423133 @default.
• W3209938416 cites W1860516218 @default.
• W3209938416 cites W1880102829 @default.
• W3209938416 cites W1908992962 @default.
• W3209938416 cites W1965174412 @default.
• W3209938416 cites W1975304818 @default.
• W3209938416 cites W1988674701 @default.
• W3209938416 cites W2007009367 @default.
• W3209938416 cites W2034580119 @default.
• W3209938416 cites W2049285362 @default.
• W3209938416 cites W2053637509 @default.
• W3209938416 cites W2059712789 @default.
• W3209938416 cites W2061596818 @default.
• W3209938416 cites W2094814043 @default.
• W3209938416 cites W2107277218 @default.
• W3209938416 cites W2114387013 @default.
• W3209938416 cites W2115788076 @default.
• W3209938416 cites W2129787935 @default.
• W3209938416 cites W2142284763 @default.
• W3209938416 cites W2143053936 @default.
• W3209938416 cites W2150244019 @default.
• W3209938416 cites W2158501840 @default.
• W3209938416 cites W2168540880 @default.
• W3209938416 cites W2172189015 @default.
• W3209938416 cites W2192080449 @default.
• W3209938416 cites W2236369785 @default.
• W3209938416 cites W2286924996 @default.
• W3209938416 cites W2296491690 @default.
• W3209938416 cites W2431141163 @default.
• W3209938416 cites W2546311779 @default.
• W3209938416 cites W2549998846 @default.
• W3209938416 cites W2586807519 @default.
• W3209938416 cites W2587439456 @default.
• W3209938416 cites W2588911159 @default.
• W3209938416 cites W2599849665 @default.
• W3209938416 cites W2739873258 @default.
• W3209938416 cites W2770236760 @default.
• W3209938416 cites W2792367472 @default.
• W3209938416 cites W2802554237 @default.
• W3209938416 cites W2848095320 @default.
• W3209938416 cites W2887911881 @default.
• W3209938416 cites W2888856107 @default.
• W3209938416 cites W2891226372 @default.
• W3209938416 cites W2892330893 @default.
• W3209938416 cites W2895231570 @default.
• W3209938416 cites W2911393502 @default.
• W3209938416 cites W2917557545 @default.
• W3209938416 cites W2921734628 @default.
• W3209938416 cites W2942803421 @default.
• W3209938416 cites W2945735701 @default.
• W3209938416 cites W2948351836 @default.
• W3209938416 cites W2959758952 @default.
• W3209938416 cites W2982106221 @default.
• W3209938416 cites W2983478501 @default.
• W3209938416 cites W3000700435 @default.
• W3209938416 cites W3004913739 @default.
• W3209938416 cites W3009623346 @default.
• W3209938416 cites W3025524685 @default.
• W3209938416 cites W3033461986 @default.
• W3209938416 cites W3039547617 @default.
• W3209938416 cites W3044228063 @default.
• W3209938416 cites W3084176717 @default.
• W3209938416 cites W2992696086 @default.
• W3209938416 doi "https://doi.org/10.3892/mmr.2021.12517" @default.
• W3209938416 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8600399" @default.
• W3209938416 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34726254" @default.
• W3209938416 hasPublicationYear "2021" @default.
• W3209938416 type Work @default.
• W3209938416 sameAs 3209938416 @default.
• W3209938416 citedByCount "9" @default.
• W3209938416 countsByYear W32099384162021 @default.
• W3209938416 countsByYear W32099384162022 @default.
• W3209938416 countsByYear W32099384162023 @default.
• W3209938416 crossrefType "journal-article" @default.
• W3209938416 hasAuthorship W3209938416A5035221303 @default.
• W3209938416 hasAuthorship W3209938416A5035590977 @default.
• W3209938416 hasAuthorship W3209938416A5065859286 @default.
• W3209938416 hasAuthorship W3209938416A5070134243 @default.
• W3209938416 hasBestOaLocation W32099384161 @default.
• W3209938416 hasConcept C104317684 @default.
• W3209938416 hasConcept C126322002 @default.
• W3209938416 hasConcept C150194340 @default.
• W3209938416 hasConcept C185592680 @default.
• W3209938416 hasConcept C2776151105 @default.
• W3209938416 hasConcept C2780114680 @default.
• W3209938416 hasConcept C2781453256 @default.
• W3209938416 hasConcept C541997718 @default.
• W3209938416 hasConcept C55493867 @default.
• W3209938416 hasConcept C62478195 @default.
• W3209938416 hasConcept C71924100 @default.
• W3209938416 hasConcept C75217442 @default.

• next