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- W3209945557 abstract "STAT3 is an oncogenic transcription factor that controls the expression of genes associated with oncogenesis and malignant progression. Persistent activation of STAT3 is observed in human malignancies, including hepatocellular carcinoma (HCC) and multiple myeloma (MM). Here, we have investigated the action of Tris(dibenzylideneacetone) dipalladium 0 (Tris DBA) on STAT3 signaling in HCC and MM cells. Tris DBA decreased cell viability, increased apoptosis, and inhibited IL-6 induced/constitutive activation of STAT3, JAK1, JAK2, and Src in HCC and MM cells. Tris DBA downmodulated the nuclear translocation of STAT3 and reduced its DNA binding ability. It upregulated the expression of SHP2 (protein and mRNA) to induce STAT3 dephosphorylation, and the inhibition of SHP2 reversed this effect. Tris DBA downregulated the expression of STAT3-driven genes, suppressed cell migration/invasion. Tris DBA significantly inhibited tumor growth in xenograft MM and orthotopic HCC preclinical mice models with a reduction in the expression of various prosurvival biomarkers in MM tumor tissues without displaying significant toxicity. Overall, Tris DBA functions as a good inhibitor of STAT3 signaling in preclinical HCC and MM models." @default.
- W3209945557 created "2021-11-08" @default.
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- W3209945557 creator A5073499085 @default.
- W3209945557 date "2021-10-31" @default.
- W3209945557 modified "2023-10-14" @default.
- W3209945557 title "Tris(dibenzylideneacetone)dipalladium(0) (Tris DBA) Abrogates Tumor Progression in Hepatocellular Carcinoma and Multiple Myeloma Preclinical Models by Regulating the STAT3 Signaling Pathway" @default.
- W3209945557 cites W1493557897 @default.
- W3209945557 cites W1545911557 @default.
- W3209945557 cites W1562057738 @default.
- W3209945557 cites W1587528990 @default.
- W3209945557 cites W1599834457 @default.
- W3209945557 cites W1812164980 @default.
- W3209945557 cites W1934957927 @default.
- W3209945557 cites W1948731184 @default.
- W3209945557 cites W1964847767 @default.
- W3209945557 cites W1991013609 @default.
- W3209945557 cites W2012173045 @default.
- W3209945557 cites W2014622924 @default.
- W3209945557 cites W2016191221 @default.
- W3209945557 cites W2016614467 @default.
- W3209945557 cites W2018659577 @default.
- W3209945557 cites W2024964331 @default.
- W3209945557 cites W2025295046 @default.
- W3209945557 cites W2068648892 @default.
- W3209945557 cites W2076971614 @default.
- W3209945557 cites W2095910264 @default.
- W3209945557 cites W2096182244 @default.
- W3209945557 cites W2099395323 @default.
- W3209945557 cites W2102912734 @default.
- W3209945557 cites W2109786000 @default.
- W3209945557 cites W2110842318 @default.
- W3209945557 cites W2119130730 @default.
- W3209945557 cites W2127754394 @default.
- W3209945557 cites W2134871530 @default.
- W3209945557 cites W2137135537 @default.
- W3209945557 cites W2140966985 @default.
- W3209945557 cites W2152750160 @default.
- W3209945557 cites W2159875179 @default.
- W3209945557 cites W2160417998 @default.
- W3209945557 cites W2165197609 @default.
- W3209945557 cites W2170930147 @default.
- W3209945557 cites W2179211029 @default.
- W3209945557 cites W2196215011 @default.
- W3209945557 cites W2241507036 @default.
- W3209945557 cites W2277406115 @default.
- W3209945557 cites W2293591396 @default.
- W3209945557 cites W2326620506 @default.
- W3209945557 cites W2336661473 @default.
- W3209945557 cites W2341035006 @default.
- W3209945557 cites W2401797579 @default.
- W3209945557 cites W2461978431 @default.
- W3209945557 cites W2490891607 @default.
- W3209945557 cites W2501536493 @default.
- W3209945557 cites W2504338811 @default.
- W3209945557 cites W2518545475 @default.
- W3209945557 cites W2528470914 @default.
- W3209945557 cites W2567401674 @default.
- W3209945557 cites W2572077158 @default.
- W3209945557 cites W2573808229 @default.
- W3209945557 cites W2575645930 @default.
- W3209945557 cites W2589094768 @default.
- W3209945557 cites W2618584271 @default.
- W3209945557 cites W2735458523 @default.
- W3209945557 cites W2743896081 @default.
- W3209945557 cites W2770054994 @default.
- W3209945557 cites W2782355083 @default.
- W3209945557 cites W2791833522 @default.
- W3209945557 cites W2802296785 @default.
- W3209945557 cites W2806456320 @default.
- W3209945557 cites W2885958700 @default.
- W3209945557 cites W2889646458 @default.
- W3209945557 cites W2890743393 @default.
- W3209945557 cites W2891863700 @default.
- W3209945557 cites W2896536135 @default.
- W3209945557 cites W2899784880 @default.
- W3209945557 cites W2903930196 @default.
- W3209945557 cites W2905373525 @default.
- W3209945557 cites W2909295436 @default.
- W3209945557 cites W2917410143 @default.
- W3209945557 cites W2942536939 @default.
- W3209945557 cites W2942539217 @default.
- W3209945557 cites W2963854884 @default.
- W3209945557 cites W2971774950 @default.
- W3209945557 cites W2976144232 @default.