FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3209968453> ?p ?o ?g. }

• W3209968453 endingPage "111476" @default.
• W3209968453 startingPage "111476" @default.
• W3209968453 abstract "Diabetic osteoporosis (DOP) is a serious complication of diabetes, which brings a heavy burden to patients' families and society. The SDF-1/CXCR4 signal pathway may be a target to prevent articular cartilage degeneration. In this study, we studied the effects of high glucose (20 mmol/L) and CXCR4 antagonist AMD3465 (10 μmol/L) on the apoptosis and gene expression of osteoblast-like cells MG63 to determine a new treatment for DOP. CCK8 and clone formation assays confirmed that AMD3465 resisted the decrease of proliferation caused by high glucose. According to the results of scratch and transwell analysis, AMD3465 could remedy the decrease of cell migration and invasion induced by high glucose. The results of flow cytometry analysis and double staining with Hoechst and PI showed AMD3465 corrected the apoptosis induced by high glucose. In addition, high glucose regulated the expression of cell cycle- and apoptosis-related proteins, while AMD3465 blocked the regulation of high glucose. Furthermore, high glucose enhanced the expression levels of SDF-1 and CXCR4 in MG63 cells, as well as the release of MMP1, 3, 9 and 13. AMD3465 inhibited the release of MMPs. The results showed that AMD3465 resisted the apoptosis of MG63 cells induced by high glucose, provided a new strategy for the therapy of DOP." @default.
• W3209968453 created "2021-11-08" @default.
• W3209968453 creator A5002501199 @default.
• W3209968453 creator A5013769680 @default.
• W3209968453 creator A5031646804 @default.
• W3209968453 creator A5035555370 @default.
• W3209968453 creator A5056436243 @default.
• W3209968453 creator A5064024990 @default.
• W3209968453 creator A5069841884 @default.
• W3209968453 creator A5075141173 @default.
• W3209968453 date "2021-06-01" @default.
• W3209968453 modified "2023-10-10" @default.
• W3209968453 title "AMD3465 (hexahydrobromide) rescues the MG63 osteoblasts against the apoptosis induced by high glucose" @default.
• W3209968453 cites W1595099528 @default.
• W3209968453 cites W1733843774 @default.
• W3209968453 cites W2047535802 @default.
• W3209968453 cites W2051517030 @default.
• W3209968453 cites W2053275761 @default.
• W3209968453 cites W2061860330 @default.
• W3209968453 cites W2077656672 @default.
• W3209968453 cites W2078005465 @default.
• W3209968453 cites W2087754901 @default.
• W3209968453 cites W2118582101 @default.
• W3209968453 cites W2125074798 @default.
• W3209968453 cites W2125637498 @default.
• W3209968453 cites W2157891776 @default.
• W3209968453 cites W2161485411 @default.
• W3209968453 cites W2410413380 @default.
• W3209968453 cites W2522659753 @default.
• W3209968453 cites W2527338241 @default.
• W3209968453 cites W2731349674 @default.
• W3209968453 doi "https://doi.org/10.1016/j.biopha.2021.111476" @default.
• W3209968453 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33773470" @default.
• W3209968453 hasPublicationYear "2021" @default.
• W3209968453 type Work @default.
• W3209968453 sameAs 3209968453 @default.
• W3209968453 citedByCount "3" @default.
• W3209968453 countsByYear W32099684532022 @default.
• W3209968453 crossrefType "journal-article" @default.
• W3209968453 hasAuthorship W3209968453A5002501199 @default.
• W3209968453 hasAuthorship W3209968453A5013769680 @default.
• W3209968453 hasAuthorship W3209968453A5031646804 @default.
• W3209968453 hasAuthorship W3209968453A5035555370 @default.
• W3209968453 hasAuthorship W3209968453A5056436243 @default.
• W3209968453 hasAuthorship W3209968453A5064024990 @default.
• W3209968453 hasAuthorship W3209968453A5069841884 @default.
• W3209968453 hasAuthorship W3209968453A5075141173 @default.
• W3209968453 hasBestOaLocation W32099684531 @default.
• W3209968453 hasConcept C109523444 @default.
• W3209968453 hasConcept C126322002 @default.
• W3209968453 hasConcept C134018914 @default.
• W3209968453 hasConcept C153911025 @default.
• W3209968453 hasConcept C161573976 @default.
• W3209968453 hasConcept C165220095 @default.
• W3209968453 hasConcept C185592680 @default.
• W3209968453 hasConcept C190283241 @default.
• W3209968453 hasConcept C202751555 @default.
• W3209968453 hasConcept C2778260815 @default.
• W3209968453 hasConcept C2779306644 @default.
• W3209968453 hasConcept C2780963292 @default.
• W3209968453 hasConcept C553184892 @default.
• W3209968453 hasConcept C55493867 @default.
• W3209968453 hasConcept C555293320 @default.
• W3209968453 hasConcept C71924100 @default.
• W3209968453 hasConcept C86803240 @default.
• W3209968453 hasConcept C95444343 @default.
• W3209968453 hasConceptScore W3209968453C109523444 @default.
• W3209968453 hasConceptScore W3209968453C126322002 @default.
• W3209968453 hasConceptScore W3209968453C134018914 @default.
• W3209968453 hasConceptScore W3209968453C153911025 @default.
• W3209968453 hasConceptScore W3209968453C161573976 @default.
• W3209968453 hasConceptScore W3209968453C165220095 @default.
• W3209968453 hasConceptScore W3209968453C185592680 @default.
• W3209968453 hasConceptScore W3209968453C190283241 @default.
• W3209968453 hasConceptScore W3209968453C202751555 @default.
• W3209968453 hasConceptScore W3209968453C2778260815 @default.
• W3209968453 hasConceptScore W3209968453C2779306644 @default.
• W3209968453 hasConceptScore W3209968453C2780963292 @default.
• W3209968453 hasConceptScore W3209968453C553184892 @default.
• W3209968453 hasConceptScore W3209968453C55493867 @default.
• W3209968453 hasConceptScore W3209968453C555293320 @default.
• W3209968453 hasConceptScore W3209968453C71924100 @default.
• W3209968453 hasConceptScore W3209968453C86803240 @default.
• W3209968453 hasConceptScore W3209968453C95444343 @default.
• W3209968453 hasLocation W32099684531 @default.
• W3209968453 hasLocation W32099684532 @default.
• W3209968453 hasOpenAccess W3209968453 @default.
• W3209968453 hasPrimaryLocation W32099684531 @default.
• W3209968453 hasRelatedWork W164936156 @default.
• W3209968453 hasRelatedWork W1949667913 @default.
• W3209968453 hasRelatedWork W2001727502 @default.
• W3209968453 hasRelatedWork W2016840219 @default.
• W3209968453 hasRelatedWork W2288066127 @default.
• W3209968453 hasRelatedWork W2366289714 @default.
• W3209968453 hasRelatedWork W2409214574 @default.
• W3209968453 hasRelatedWork W3152173255 @default.
• W3209968453 hasRelatedWork W43051378 @default.
• W3209968453 hasRelatedWork W4367836243 @default.

• next