Matches in SemOpenAlex for { <https://semopenalex.org/work/W3209972844> ?p ?o ?g. }
- W3209972844 endingPage "11910" @default.
- W3209972844 startingPage "11910" @default.
- W3209972844 abstract "5-hydroxytryptamine type 3 (5-HT3) receptors are ligand gated ion channels, which clearly distinguish their mode of action from the other G-protein coupled 5-HT or serotonin receptors. 5-HT3 receptors are well established targets for emesis and gastrointestinal mobility and are used as adjunct targets in treating schizophrenia. However, the distribution of these receptors is wider than the nervous system and there is potential that these additional sites can be targeted to modulate inflammatory and/or metabolic conditions. Recent progress in structural biology and pharmacology of 5-HT3 receptors have provided profound insights into mechanisms of their action. These advances, combined with insights into clinical relevance of mutations in genes encoding 5-HT3 subunits and increasing understanding of their implications in patient's predisposition to diseases and response to the treatment, open new avenues for personalized precision medicine. In this review, we recap on the current status of 5-HT3 receptor-based therapies using a biochemical and physiological perspective. We assess the potential for targeting 5-HT3 receptors in conditions involving metabolic or inflammatory disorders based on recent findings, underscoring the challenges and limitations of this approach." @default.
- W3209972844 created "2021-11-08" @default.
- W3209972844 creator A5015831998 @default.
- W3209972844 creator A5049805667 @default.
- W3209972844 creator A5050960417 @default.
- W3209972844 creator A5066233352 @default.
- W3209972844 date "2021-11-02" @default.
- W3209972844 modified "2023-09-27" @default.
- W3209972844 title "Tapping into 5-HT3 Receptors to Modify Metabolic and Immune Responses" @default.
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