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- W3209997788 endingPage "428" @default.
- W3209997788 startingPage "395" @default.
- W3209997788 abstract "The human brain undergoes rapid changes from mid-gestation to postnatal 2 years of age. These rapid structural and functional changes underlie initial cognitive and behavioral development. Decades of histological studies have identified strong spatial and functional maturation gradients in human brain. Recent improvements in magnetic resonance imaging (MRI) techniques, especially diffusion MRI (dMRI), functional MRI (fMRI) and perfusion MRI (pMRI) have provided unprecedented opportunities to noninvasively quantify and map these early developmental changes at whole brain and regional levels. Here, we review recent advances in early brain development during the second half of gestation and the first two postnatal years using modern MR techniques. Specifically, we review MRI studies delineating spatiotemporally heterogeneous macro- and micro-structural changes in cerebral cortical regions and white mater tracts, as well as functional maturation across brain regions. In addition, we briefly discuss connectomics, metabolic and physiological changes during this developmental period. These imaging studies converge into typically developing brain structural and functional maturational curves that are distinctive across brain regions, setting the stage for understanding aberrant brain development in neurological or neuropsychiatric disorders." @default.
- W3209997788 created "2021-11-08" @default.
- W3209997788 creator A5003616974 @default.
- W3209997788 creator A5057295149 @default.
- W3209997788 creator A5080400240 @default.
- W3209997788 creator A5086152043 @default.
- W3209997788 date "2021-01-01" @default.
- W3209997788 modified "2023-09-23" @default.
- W3209997788 title "Imaging early brain structural and functional development" @default.
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