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- W3210018682 abstract "The emergence of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has resulted in a pandemic causing significant damage to public health and the economy. Efforts to understand the mechanisms of Coronavirus Disease 2019 (COVID-19) have been hampered by the lack of robust mouse models. To overcome this barrier, we used a reverse genetic system to generate a mouse-adapted strain of SARS-CoV-2. Incorporating key mutations found in SARS-CoV-2 variants, this model recapitulates critical elements of human infection including viral replication in the lung, immune cell infiltration, and significant in vivo disease. Importantly, mouse adaptation of SARS-CoV-2 does not impair replication in human airway cells and maintains antigenicity similar to human SARS-CoV-2 strains. Coupled with the incorporation of mutations found in variants of concern, CMA3p20 offers several advantages over other mouse-adapted SARS-CoV-2 strains. Using this model, we demonstrate that SARS-CoV-2-infected mice are protected from lethal challenge with the original Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV), suggesting immunity from heterologous Coronavirus (CoV) strains. Together, the results highlight the use of this mouse model for further study of SARS-CoV-2 infection and disease." @default.
- W3210018682 created "2021-11-08" @default.
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- W3210018682 date "2021-11-04" @default.
- W3210018682 modified "2023-10-18" @default.
- W3210018682 title "Mouse-adapted SARS-CoV-2 protects animals from lethal SARS-CoV challenge" @default.
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- W3210018682 doi "https://doi.org/10.1371/journal.pbio.3001284" @default.
- W3210018682 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8594810" @default.
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