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• W3210028666 abstract "Neutrophils are an integral component of the innate immune system and key regulators of cell-mediated defense against bacterial and fungal pathogens. The potential of granulocyte transfusions has been investigated to temporarily replenish innate immune function to prevent and/or treat infections in patients with severe neutropenia or neutrophil dysfunction. However, evidence has been largely theoretical, experimental, and/or inconclusive. Clinical efficacy has yet to be confirmed by large-scale randomized controlled clinical trials. Performing such trials has been hampered by low granulocyte collection yield and poor patient accrual. We provide a practical summary of the current literature surrounding the practice of granulocyte transfusion." @default.
• W3210028666 created "2021-11-08" @default.
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• W3210028666 date "2021-12-01" @default.
• W3210028666 modified "2023-09-26" @default.
• W3210028666 title "Granulocyte Transfusion" @default.
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• W3210028666 doi "https://doi.org/10.1016/j.cll.2021.07.007" @default.
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