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• W3210054575 abstract "Synovial inflammation influences the progression of osteoarthritis (OA). Herein, we aimed to identify potential biomarkers and analyze transcriptional regulatory-immune mechanism of synovitis in OA using weighted gene coexpression network analysis (WGCNA).A data set of OA synovium samples (GSE55235) was analyzed based on WGCNA. The most significant module with OA was identified and function annotation of the module was performed, following which the hub genes of the module were identified using Pearson correlation and a protein-protein interaction network was constructed. A transcriptional regulatory network of hub genes was constructed using the TRRUST database. The immune cell infiltration of OA samples was evaluated using the single-sample Gene Set Enrichment Analysis (ssGSEA) method. The hub genes coexpressed in multiple tissues were then screened out using data sets of synovium, cartilage, chondrocyte, subchondral bone, and synovial fluid samples. Finally, transcriptional factors and coexpressed hub genes were validated via experiments.The turquoise module of GSE55235 was identified via WGCNA. Functional annotation analysis showed that mineral absorption and FoxO signaling pathway were mostly enriched in the module. JUN, EGR1, FOSB, and KLF4 acted as central nodes in protein-protein interaction network and transcription factors to connect several target genes. Activated B cell, activated CD4T cell, eosinophil, neutrophil, and type 17 T helper cell showed high immune infiltration, while FOSB, KLF6, and MYBL2 showed significant negative correlation with type 17 T helper cell.Our results suggest that the expression level of apolipoprotein D (APOD) was correlated with OA. Furthermore, transcriptional regulatory-immune network was constructed, which may contribute to OA therapy." @default.
• W3210054575 created "2021-11-08" @default.
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• W3210054575 date "2021-10-31" @default.
• W3210054575 modified "2023-10-16" @default.
• W3210054575 title "Apolipoprotein D as a Potential Biomarker and Construction of a Transcriptional Regulatory-Immune Network Associated with Osteoarthritis by Weighted Gene Coexpression Network Analysis" @default.
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• W3210054575 doi "https://doi.org/10.1177/19476035211053824" @default.
• W3210054575 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34719950" @default.
• W3210054575 hasPublicationYear "2021" @default.
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