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• W3210063562 endingPage "116251" @default.
• W3210063562 startingPage "116251" @default.
• W3210063562 abstract "The developing fetus may be particularly susceptibility to environmental osteotoxicants, but studies of pregnancy phthalate exposures and childhood bone health are scarce.To examine relations of pregnancy phthalate exposure biomarkers with early adolescent bone mineral density (BMD) and bone mineral content (BMC) in a prospective birth cohort.We used data from 223 pregnant mothers and their children enrolled in a Cincinnati, OH area cohort from 2003 to 2006. We quantified monoethyl phthalate (MEP), monoisobutyl phthalate, monobutyl phthalate, monobenzyl phthalate, mono-(3-carboxypropyl) phthalate (MCPP), and four metabolites of di-2-ethylhexyl phthalate in maternal urine collected at 16 and 26 weeks gestation, and calculated the average of creatinine-standardized concentrations. Using dual x-ray absorptiometry measures at age 12 years, we calculated BMD and BMC Z-scores for six skeletal sites. In overall and sex-stratified models, we estimated covariate-adjusted associations per 2-fold increase in phthalate biomarker concentrations using linear regression, and estimated joint effects of the phthalate biomarkers mixture using Bayesian kernel machine regression (BKMR) and quantile g-computation.In single phthalate models, several biomarkers were positively associated with BMC and BMD. For example, each doubling of MEP and MCPP, 1/3rd distal radius BMD Z-score increased by 0.09 (95% CI: 0.01, 0.17) and 0.16 (95% CI: 0.01, 0.31), respectively. For phthalate mixtures, associations were generally U-shaped among males and positive-linear among females, using both statistical methods. Mixture associations were strongest with forearm sites: in BKMR models, increasing all biomarkers from the 50th to 90th percentile was associated with a 0.64 (95% CI: 0.01, 1.28) greater 1/3rd distal radius BMD Z-score in males, and a 0.49 (95% CI: -0.13, 1.10) greater ultradistal radius BMD Z-score in females.In this study, phthalate exposures during gestation were associated with increased BMD Z-scores in early adolescence, though further research is needed to determine implications for long-term skeletal health." @default.
• W3210063562 created "2021-11-08" @default.
• W3210063562 creator A5013602281 @default.
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• W3210063562 date "2022-01-01" @default.
• W3210063562 modified "2023-10-16" @default.
• W3210063562 title "Associations of pregnancy phthalate concentrations and their mixture with early adolescent bone mineral content and density: The Health Outcomes and Measures of the Environment (HOME) study" @default.
• W3210063562 cites W1606867770 @default.
• W3210063562 cites W1836565766 @default.
• W3210063562 cites W1918275002 @default.
• W3210063562 cites W1963720275 @default.
• W3210063562 cites W1964085086 @default.
• W3210063562 cites W1967640708 @default.
• W3210063562 cites W1975011880 @default.
• W3210063562 cites W1978630883 @default.
• W3210063562 cites W1979452460 @default.
• W3210063562 cites W1981067059 @default.
• W3210063562 cites W1984634361 @default.
• W3210063562 cites W1986987737 @default.
• W3210063562 cites W1989530871 @default.
• W3210063562 cites W1989963382 @default.
• W3210063562 cites W1994744000 @default.
• W3210063562 cites W2002786747 @default.
• W3210063562 cites W2009208205 @default.
• W3210063562 cites W2016069630 @default.
• W3210063562 cites W2016709601 @default.
• W3210063562 cites W2017345460 @default.
• W3210063562 cites W2020635117 @default.
• W3210063562 cites W2020659036 @default.
• W3210063562 cites W2022998841 @default.
• W3210063562 cites W2031283052 @default.
• W3210063562 cites W2033548902 @default.
• W3210063562 cites W2036058164 @default.
• W3210063562 cites W2041454621 @default.
• W3210063562 cites W2043860874 @default.
• W3210063562 cites W2046802028 @default.
• W3210063562 cites W2050574400 @default.
• W3210063562 cites W2055634200 @default.
• W3210063562 cites W2057962659 @default.
• W3210063562 cites W2065412063 @default.
• W3210063562 cites W2069995375 @default.
• W3210063562 cites W2073295043 @default.
• W3210063562 cites W2084026465 @default.
• W3210063562 cites W2085816378 @default.
• W3210063562 cites W2091042653 @default.
• W3210063562 cites W2091235933 @default.
• W3210063562 cites W2092579688 @default.
• W3210063562 cites W2097633545 @default.
• W3210063562 cites W2101160904 @default.
• W3210063562 cites W2102556062 @default.
• W3210063562 cites W2119221073 @default.
• W3210063562 cites W2120660861 @default.
• W3210063562 cites W2124359549 @default.
• W3210063562 cites W2128241866 @default.
• W3210063562 cites W2131486343 @default.
• W3210063562 cites W2139857937 @default.
• W3210063562 cites W2146539655 @default.
• W3210063562 cites W2150239640 @default.
• W3210063562 cites W2161583137 @default.
• W3210063562 cites W2163191787 @default.
• W3210063562 cites W2166507499 @default.
• W3210063562 cites W2166972916 @default.
• W3210063562 cites W2176728586 @default.
• W3210063562 cites W2185799454 @default.
• W3210063562 cites W2257516528 @default.
• W3210063562 cites W2265634200 @default.
• W3210063562 cites W2303415821 @default.
• W3210063562 cites W2317471983 @default.
• W3210063562 cites W2321635716 @default.
• W3210063562 cites W2337977161 @default.
• W3210063562 cites W2344335473 @default.
• W3210063562 cites W2382021917 @default.
• W3210063562 cites W2415893412 @default.
• W3210063562 cites W2522500216 @default.
• W3210063562 cites W2524686607 @default.
• W3210063562 cites W2553727184 @default.
• W3210063562 cites W2564124967 @default.
• W3210063562 cites W2588375748 @default.
• W3210063562 cites W2591696989 @default.
• W3210063562 cites W2607456148 @default.
• W3210063562 cites W2724347615 @default.
• W3210063562 cites W2738919786 @default.
• W3210063562 cites W2756116170 @default.
• W3210063562 cites W2769487897 @default.
• W3210063562 cites W2790407756 @default.
• W3210063562 cites W2809629560 @default.
• W3210063562 cites W2809971549 @default.
• W3210063562 cites W2892737990 @default.
• W3210063562 cites W2895363664 @default.
• W3210063562 cites W2918173153 @default.

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