FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3210078367> ?p ?o ?g. }

• W3210078367 abstract "Abstract CRISPR-Cas9 recessive genome-wide pooled screens have allowed systematic explorations of weaknesses and vulnerabilities existing in cancer cells, across different tissue lineages at unprecedented accuracy and scale. The identification of novel genes essential for selective cancer cell survival is currently one of the main applications of this technology. Towards this aim, distinguishing genes that are constitutively essential (invariantly across tissues and genomic contexts, i.e. core-fitness genes) from those whose essentiality is associated with molecular features peculiar to certain cancers is of paramount importance for identifying new oncology therapeutic targets. This is crucial to assess the risk of a candidate target’s suppression impacting critical cellular processes that are unspecific to cancer. On the other hand, identifying new human core-fitness genes might also elucidate new mechanisms involved in tissue-specific genetic diseases. We present CoRe: an open-source R package implementing established and novel methods for the identification of core-fitness genes based on joint analyses of data from multiple CRISPR-Cas9 screens. In addition, we present results from a fully reproducible benchmarking pipeline demonstrating that CoRe outperforms other state-of-the-art methods, and it yields more reliable sets of core-fitness and common-essential genes with respect to existing reference sets and methods." @default.
• W3210078367 created "2021-11-08" @default.
• W3210078367 creator A5023862882 @default.
• W3210078367 creator A5027896699 @default.
• W3210078367 creator A5056181848 @default.
• W3210078367 creator A5084143561 @default.
• W3210078367 creator A5084431909 @default.
• W3210078367 creator A5085472676 @default.
• W3210078367 creator A5090904309 @default.
• W3210078367 date "2021-05-26" @default.
• W3210078367 modified "2023-10-16" @default.
• W3210078367 title "CoRe: A robustly benchmarked R package for the identification of core fitness genes in genome-wide pooled CRISPR knock-out screens" @default.
• W3210078367 cites W1934704664 @default.
• W3210078367 cites W1968342623 @default.
• W3210078367 cites W2003171404 @default.
• W3210078367 cites W2003223511 @default.
• W3210078367 cites W2031211461 @default.
• W3210078367 cites W2075027707 @default.
• W3210078367 cites W2123746851 @default.
• W3210078367 cites W2130410032 @default.
• W3210078367 cites W2131395804 @default.
• W3210078367 cites W2138164217 @default.
• W3210078367 cites W2141749416 @default.
• W3210078367 cites W2151819406 @default.
• W3210078367 cites W2174686320 @default.
• W3210078367 cites W2180291937 @default.
• W3210078367 cites W2338215681 @default.
• W3210078367 cites W2533641274 @default.
• W3210078367 cites W2568849010 @default.
• W3210078367 cites W2704159227 @default.
• W3210078367 cites W2727479110 @default.
• W3210078367 cites W2734573616 @default.
• W3210078367 cites W2739511077 @default.
• W3210078367 cites W2761872853 @default.
• W3210078367 cites W2766971792 @default.
• W3210078367 cites W2783151804 @default.
• W3210078367 cites W2893209354 @default.
• W3210078367 cites W2925372744 @default.
• W3210078367 cites W2936686072 @default.
• W3210078367 cites W2937947908 @default.
• W3210078367 cites W2947035301 @default.
• W3210078367 cites W2950642204 @default.
• W3210078367 cites W2952121859 @default.
• W3210078367 cites W2970555691 @default.
• W3210078367 cites W2971136217 @default.
• W3210078367 cites W2977510709 @default.
• W3210078367 cites W2994966800 @default.
• W3210078367 cites W3005394826 @default.
• W3210078367 cites W3008056245 @default.
• W3210078367 cites W3012585054 @default.
• W3210078367 cites W3014684155 @default.
• W3210078367 cites W3043613986 @default.
• W3210078367 cites W3047825284 @default.
• W3210078367 cites W3093253498 @default.
• W3210078367 cites W3121522323 @default.
• W3210078367 cites W3134916687 @default.
• W3210078367 cites W3153695932 @default.
• W3210078367 doi "https://doi.org/10.1101/2021.05.25.445610" @default.
• W3210078367 hasPublicationYear "2021" @default.
• W3210078367 type Work @default.
• W3210078367 sameAs 3210078367 @default.
• W3210078367 citedByCount "1" @default.
• W3210078367 countsByYear W32100783672022 @default.
• W3210078367 crossrefType "posted-content" @default.
• W3210078367 hasAuthorship W3210078367A5023862882 @default.
• W3210078367 hasAuthorship W3210078367A5027896699 @default.
• W3210078367 hasAuthorship W3210078367A5056181848 @default.
• W3210078367 hasAuthorship W3210078367A5084143561 @default.
• W3210078367 hasAuthorship W3210078367A5084431909 @default.
• W3210078367 hasAuthorship W3210078367A5085472676 @default.
• W3210078367 hasAuthorship W3210078367A5090904309 @default.
• W3210078367 hasBestOaLocation W32100783671 @default.
• W3210078367 hasConcept C104317684 @default.
• W3210078367 hasConcept C116834253 @default.
• W3210078367 hasConcept C132455925 @default.
• W3210078367 hasConcept C141231307 @default.
• W3210078367 hasConcept C144133560 @default.
• W3210078367 hasConcept C162853370 @default.
• W3210078367 hasConcept C54355233 @default.
• W3210078367 hasConcept C59822182 @default.
• W3210078367 hasConcept C70721500 @default.
• W3210078367 hasConcept C86251818 @default.
• W3210078367 hasConcept C86803240 @default.
• W3210078367 hasConcept C98108389 @default.
• W3210078367 hasConceptScore W3210078367C104317684 @default.
• W3210078367 hasConceptScore W3210078367C116834253 @default.
• W3210078367 hasConceptScore W3210078367C132455925 @default.
• W3210078367 hasConceptScore W3210078367C141231307 @default.
• W3210078367 hasConceptScore W3210078367C144133560 @default.
• W3210078367 hasConceptScore W3210078367C162853370 @default.
• W3210078367 hasConceptScore W3210078367C54355233 @default.
• W3210078367 hasConceptScore W3210078367C59822182 @default.
• W3210078367 hasConceptScore W3210078367C70721500 @default.
• W3210078367 hasConceptScore W3210078367C86251818 @default.
• W3210078367 hasConceptScore W3210078367C86803240 @default.
• W3210078367 hasConceptScore W3210078367C98108389 @default.
• W3210078367 hasLocation W32100783671 @default.
• W3210078367 hasOpenAccess W3210078367 @default.
• W3210078367 hasPrimaryLocation W32100783671 @default.
• W3210078367 hasRelatedWork W2077190448 @default.

• next