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- W3210097269 endingPage "1805" @default.
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- W3210097269 abstract "Hepatitis C virus (HCV) is a major cause of chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma (HCC) worldwide. Among the structural proteins of HCV, the HCV core protein has the ability to regulate gene transcription, lipid metabolism, cell proliferation, apoptosis, and autophagy, all of which are closely related to the development of HCC. Transgenic mice carrying the HCV core gene exhibited age-dependent insulin resistance, hepatic steatosis, and HCC that resembled the clinical characteristics of chronic hepatitis C patients. Several dietary modifications, including calorie restriction and diets rich in saturated fatty acids, trans fatty acids, or cholesterol, were found to influence hepatic steatogenesis and tumorigenesis in HCV core gene transgenic mice. These strategies modulated hepatocellular stress and proliferation, in addition to hepatic fibrotic processes and the microenvironment, thereby corroborating a close interconnection between dietary habits and steatosis-related hepatocarcinogenesis. In this review, we summarize the findings obtained from mouse models transgenic for the HCV genome, with a special focus on HCV core gene transgenic mice, and discuss the mechanisms of steatogenesis and hepatocarcinogenesis induced by the HCV core protein and the impact of dietary habits on steatosis-derived HCC development." @default.
- W3210097269 created "2021-11-08" @default.
- W3210097269 creator A5008613221 @default.
- W3210097269 creator A5036849639 @default.
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- W3210097269 creator A5082222815 @default.
- W3210097269 date "2021-12-01" @default.
- W3210097269 modified "2023-10-17" @default.
- W3210097269 title "Mechanisms of Steatosis-Derived Hepatocarcinogenesis: Lessons from HCV Core Gene Transgenic Mice" @default.
- W3210097269 cites W1456504179 @default.
- W3210097269 cites W1520005158 @default.
- W3210097269 cites W1590736681 @default.
- W3210097269 cites W1706687021 @default.
- W3210097269 cites W1796179288 @default.
- W3210097269 cites W1873531632 @default.
- W3210097269 cites W1939545062 @default.
- W3210097269 cites W1972373954 @default.
- W3210097269 cites W1972559150 @default.
- W3210097269 cites W1973810265 @default.
- W3210097269 cites W1975962588 @default.
- W3210097269 cites W1976064871 @default.
- W3210097269 cites W1976875921 @default.
- W3210097269 cites W1977139084 @default.
- W3210097269 cites W1977238306 @default.
- W3210097269 cites W1979931682 @default.
- W3210097269 cites W1980737728 @default.
- W3210097269 cites W1982501391 @default.
- W3210097269 cites W1986962882 @default.
- W3210097269 cites W1988045726 @default.
- W3210097269 cites W1990112891 @default.
- W3210097269 cites W1995752427 @default.
- W3210097269 cites W1996826591 @default.
- W3210097269 cites W1998420980 @default.
- W3210097269 cites W2001602562 @default.
- W3210097269 cites W2005077809 @default.
- W3210097269 cites W2006222088 @default.
- W3210097269 cites W2006757932 @default.
- W3210097269 cites W2007505836 @default.
- W3210097269 cites W2008818215 @default.
- W3210097269 cites W2010264142 @default.
- W3210097269 cites W2014265355 @default.
- W3210097269 cites W2017670453 @default.
- W3210097269 cites W2020217881 @default.
- W3210097269 cites W2024840555 @default.
- W3210097269 cites W2030153054 @default.
- W3210097269 cites W2031170097 @default.
- W3210097269 cites W2034063619 @default.
- W3210097269 cites W2034323667 @default.
- W3210097269 cites W2035242291 @default.
- W3210097269 cites W2044397277 @default.
- W3210097269 cites W2050898100 @default.
- W3210097269 cites W2052467883 @default.
- W3210097269 cites W2053978445 @default.
- W3210097269 cites W2060018191 @default.
- W3210097269 cites W2060151133 @default.
- W3210097269 cites W2061122330 @default.
- W3210097269 cites W2062473966 @default.
- W3210097269 cites W2063551671 @default.
- W3210097269 cites W2067369664 @default.
- W3210097269 cites W2068437958 @default.
- W3210097269 cites W2068638478 @default.
- W3210097269 cites W2077875665 @default.
- W3210097269 cites W2080835548 @default.
- W3210097269 cites W2082189626 @default.
- W3210097269 cites W2086127478 @default.
- W3210097269 cites W2088053309 @default.
- W3210097269 cites W2102298532 @default.
- W3210097269 cites W2109457390 @default.
- W3210097269 cites W2112293207 @default.
- W3210097269 cites W2114001235 @default.
- W3210097269 cites W2118276142 @default.
- W3210097269 cites W2120775018 @default.
- W3210097269 cites W2123511080 @default.
- W3210097269 cites W2125422148 @default.
- W3210097269 cites W2126271291 @default.
- W3210097269 cites W2138004489 @default.
- W3210097269 cites W2138051219 @default.
- W3210097269 cites W2139252765 @default.
- W3210097269 cites W2143885375 @default.
- W3210097269 cites W2145107075 @default.
- W3210097269 cites W2146274115 @default.
- W3210097269 cites W2154803647 @default.
- W3210097269 cites W2163726900 @default.
- W3210097269 cites W2164340474 @default.
- W3210097269 cites W2205982384 @default.
- W3210097269 cites W2391958150 @default.
- W3210097269 cites W2404952942 @default.
- W3210097269 cites W2413962043 @default.
- W3210097269 cites W2509004031 @default.
- W3210097269 cites W2531805971 @default.
- W3210097269 cites W2563539433 @default.
- W3210097269 cites W2577888605 @default.
- W3210097269 cites W2593099486 @default.