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• W3210116997 abstract "Background/Aim: Per literature, patients with epidermal growth factor receptor (EGFR) exon-20 insertions respond poorly to tyrosine kinase inhibitors (TKIs). This study analyzed real-world data to examine the prognostic and predictive value of these mutations. Patients and Methods: We conducted a retrospective cohort study using Czech TULUNG Registry data, with data on multiple mutation types, collected in 2011-2020. Results: We analyzed 554 (95.85%) patients with EGFR exon-19 deletions or exon-21 L858R substitutions and 24 (4.15%) patients with exon-20 insertions who received first-line high-value therapies. We summarized clinical characteristics and outcomes in all patients and by cohort. The risk of progression was statistically significantly higher (86%) in the exon-20 insertion cohort compared to the cohort with other mutations. Although not statistically significant, the risk of death was 44% higher in patients with exon-20 insertions. Conclusion: Advanced NSCLC patients with rare EGFR exon-20 insertions have a high risk of progression." @default.
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• W3210116997 date "2021-11-01" @default.
• W3210116997 modified "2023-10-17" @default.
• W3210116997 title "Prognostic Value of<i>EGFR</i>Exon-20 Insertions in Czech Patients With Advanced Non-small Cell Lung Cancer" @default.
• W3210116997 doi "https://doi.org/10.21873/anticanres.15378" @default.
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