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- W3210130528 abstract "Genomic imprinting is a term used for an intergenerational epigenetic inheritance and involves a subset of genes expressed in a parent-of-origin-dependent way. Imprinted genes are expressed preferentially from either the paternally or maternally inherited allele. Long non-coding RNAs play essential roles in regulating this allele-specific expression. In several well-studied imprinting clusters, long non-coding RNAs have been found to be essential in regulating temporal- and spatial-specific establishment and maintenance of imprinting patterns. Furthermore, recent insights into the epigenetic pathological mechanisms underlying human genomic imprinting disorders suggest that allele-specific expressed imprinted long non-coding RNAs serve as an upstream regulator of the expression of other protein-coding or non-coding imprinted genes in the same cluster. Aberrantly expressed long non-coding RNAs result in bi-allelic expression or silencing of neighboring imprinted genes. Here, we review the emerging roles of long non-coding RNAs in regulating the expression of imprinted genes, especially in human imprinting disorders, and discuss three strategies targeting the central long non-coding RNA UBE3A-ATS for the purpose of developing therapies for the imprinting disorders Prader-Willi syndrome and Angelman syndrome. In summary, a better understanding of long non-coding RNA-related mechanisms is key to the development of potential therapeutic targets for human imprinting disorders." @default.
- W3210130528 created "2021-11-08" @default.
- W3210130528 creator A5005488530 @default.
- W3210130528 creator A5021934954 @default.
- W3210130528 creator A5052010465 @default.
- W3210130528 creator A5076386494 @default.
- W3210130528 creator A5077428966 @default.
- W3210130528 date "2021-10-25" @default.
- W3210130528 modified "2023-10-12" @default.
- W3210130528 title "The Role of Long Non-coding RNAs in Human Imprinting Disorders: Prospective Therapeutic Targets" @default.
- W3210130528 cites W1502342189 @default.
- W3210130528 cites W1589590998 @default.
- W3210130528 cites W1637500350 @default.
- W3210130528 cites W1784280110 @default.
- W3210130528 cites W1844199574 @default.
- W3210130528 cites W1961597426 @default.
- W3210130528 cites W1964789204 @default.
- W3210130528 cites W1965883073 @default.
- W3210130528 cites W1967481218 @default.
- W3210130528 cites W1967706132 @default.
- W3210130528 cites W1968475322 @default.
- W3210130528 cites W1973062929 @default.
- W3210130528 cites W1975993845 @default.
- W3210130528 cites W1976274498 @default.
- W3210130528 cites W1977459685 @default.
- W3210130528 cites W1977709885 @default.
- W3210130528 cites W1978715316 @default.
- W3210130528 cites W1980156946 @default.
- W3210130528 cites W1980312138 @default.
- W3210130528 cites W1982946759 @default.
- W3210130528 cites W1983034375 @default.
- W3210130528 cites W1984948945 @default.
- W3210130528 cites W1985513877 @default.
- W3210130528 cites W1985567838 @default.
- W3210130528 cites W1989126702 @default.
- W3210130528 cites W1997188614 @default.
- W3210130528 cites W1999307118 @default.
- W3210130528 cites W2000046950 @default.
- W3210130528 cites W2001206796 @default.
- W3210130528 cites W2002202527 @default.
- W3210130528 cites W2003849576 @default.
- W3210130528 cites W2004078197 @default.
- W3210130528 cites W2004429089 @default.
- W3210130528 cites W2006603866 @default.
- W3210130528 cites W2007227912 @default.
- W3210130528 cites W2007263599 @default.
- W3210130528 cites W2007963738 @default.
- W3210130528 cites W2009940298 @default.
- W3210130528 cites W2010043305 @default.
- W3210130528 cites W2014534727 @default.
- W3210130528 cites W2014921813 @default.
- W3210130528 cites W2015649315 @default.
- W3210130528 cites W2016365513 @default.
- W3210130528 cites W2018293583 @default.
- W3210130528 cites W2019122937 @default.
- W3210130528 cites W2020898306 @default.
- W3210130528 cites W2021905453 @default.
- W3210130528 cites W2022030369 @default.
- W3210130528 cites W2022199909 @default.
- W3210130528 cites W2028462657 @default.
- W3210130528 cites W2028823361 @default.
- W3210130528 cites W2030282106 @default.
- W3210130528 cites W2031896201 @default.
- W3210130528 cites W2031921215 @default.
- W3210130528 cites W2032555022 @default.
- W3210130528 cites W2034403814 @default.
- W3210130528 cites W2036322711 @default.
- W3210130528 cites W2036402097 @default.
- W3210130528 cites W2036441876 @default.
- W3210130528 cites W2036636377 @default.
- W3210130528 cites W2040561411 @default.
- W3210130528 cites W2040600097 @default.
- W3210130528 cites W2040751058 @default.
- W3210130528 cites W2042794051 @default.
- W3210130528 cites W2043203820 @default.
- W3210130528 cites W2043611593 @default.
- W3210130528 cites W2044912691 @default.
- W3210130528 cites W2045435533 @default.
- W3210130528 cites W2045904517 @default.
- W3210130528 cites W2046295100 @default.
- W3210130528 cites W2048654855 @default.
- W3210130528 cites W2049356067 @default.
- W3210130528 cites W2050480410 @default.
- W3210130528 cites W2050994249 @default.
- W3210130528 cites W2052721941 @default.
- W3210130528 cites W2053758959 @default.
- W3210130528 cites W2054191153 @default.
- W3210130528 cites W2055550188 @default.
- W3210130528 cites W2057418848 @default.
- W3210130528 cites W2058940094 @default.
- W3210130528 cites W2059968749 @default.
- W3210130528 cites W2060187824 @default.
- W3210130528 cites W2060967135 @default.
- W3210130528 cites W2061385180 @default.
- W3210130528 cites W2061650108 @default.
- W3210130528 cites W2063819447 @default.
- W3210130528 cites W2064140451 @default.
- W3210130528 cites W2064815984 @default.
- W3210130528 cites W2067410483 @default.
- W3210130528 cites W2069223267 @default.