FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3210136110> ?p ?o ?g. }

• W3210136110 endingPage "S106" @default.
• W3210136110 startingPage "S105" @default.
• W3210136110 abstract "Approximately 50% of patients treated with curative intent radiotherapy for limited stage follicular lymphoma (FL) will have a lymphoma relapse. The ideal follow-up strategy for detecting relapse is uncertain. The purpose of this study was to evaluate the impact of surveillance imaging (SI) in patients treated with radiotherapy for limited stage follicular lymphoma (FL).Patients with limited stage IA-IIA, grade 1-3A, FL treated with curative intent radiotherapy alone between 2000-2015 were retrospectively reviewed. Relapse detection was categorized into clinical detection (investigations based on signs/symptoms or laboratory abnormalities) or SI detection (radiologic investigations in asymptomatic patients). Survival outcomes were stratified based on method of relapse detection.A total of 330 patients were included with a median follow-up of 8.1 (0.5-20.0) years. All patients received ≥20Gy of involved site radiotherapy (ISRT). 222 (67.3%) patients had SI investigations with a mean of 0.4 (0.1-1.7) per year of follow-up. The most common SI modality used was computed tomography (48.6%). Of all SI investigations (n = 830), 761 (91.7%) showed no evidence of relapse, 49 (5.9%) showed findings of suspected relapse that were that were subsequently found to be false positive, and 20 (2.4%) led to confirmed relapse. The resulting positive predictive value and specificity of SI was 29.0% and 94.0%, respectively. In the follow-up period, 146 (44.2%) patients had a relapse; 126 (86.3%) were detected clinically and 20 (13.7%) were detected with SI. In relapses that were clinically detected (n = 126), 11 (8.7%) were associated with clinically significant patient morbidity, manifesting as deep vein thrombosis (n = 2), pleural effusion (n = 1), biliary duct obstruction (n = 1), renal failure (n = 2), spinal cord or nerve root involvement (n = 4), or symptomatic hypercalcemia (n = 1). The 5- and 10-year overall survival (OS) from the date of diagnosis were 85.6% and 65.2% for clinically detected versus 84.7% and 74.1% for SI detected relapses (P = 0.71). The 5- and 10-year OS from the date of relapse were 70.1% and 50.6% for clinically detected versus 80.2% and 59.4% for SI detected relapses (P = 0.54).This retrospective cohort revealed no significant OS differences between relapse detection by SI versus clinical assessment. The incidence of morbidity was low in relapses that were detected clinically. Only 2.4% of SI investigations led to a confirmed relapse suggesting they may have limited utility in the follow-up of limited stage FL patients treated with curative intent radiotherapy. A prospective analysis of cost-effectiveness and impact of SI on psychological and physical morbidity may help guide clinicians when considering a SI follow-up strategy." @default.
• W3210136110 created "2021-11-08" @default.
• W3210136110 creator A5006888644 @default.
• W3210136110 creator A5009657374 @default.
• W3210136110 creator A5017873196 @default.
• W3210136110 creator A5021133318 @default.
• W3210136110 creator A5023096496 @default.
• W3210136110 creator A5026641386 @default.
• W3210136110 creator A5045731423 @default.
• W3210136110 creator A5053501729 @default.
• W3210136110 creator A5059082232 @default.
• W3210136110 creator A5062342454 @default.
• W3210136110 creator A5062748816 @default.
• W3210136110 creator A5070464513 @default.
• W3210136110 creator A5083101716 @default.
• W3210136110 date "2021-11-01" @default.
• W3210136110 modified "2023-09-23" @default.
• W3210136110 title "The Impact of Surveillance Imaging After Curative Intent Radiotherapy for Limited Stage Follicular Lymphoma" @default.
• W3210136110 doi "https://doi.org/10.1016/j.ijrobp.2021.07.244" @default.
• W3210136110 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34700401" @default.
• W3210136110 hasPublicationYear "2021" @default.
• W3210136110 type Work @default.
• W3210136110 sameAs 3210136110 @default.
• W3210136110 citedByCount "0" @default.
• W3210136110 crossrefType "journal-article" @default.
• W3210136110 hasAuthorship W3210136110A5006888644 @default.
• W3210136110 hasAuthorship W3210136110A5009657374 @default.
• W3210136110 hasAuthorship W3210136110A5017873196 @default.
• W3210136110 hasAuthorship W3210136110A5021133318 @default.
• W3210136110 hasAuthorship W3210136110A5023096496 @default.
• W3210136110 hasAuthorship W3210136110A5026641386 @default.
• W3210136110 hasAuthorship W3210136110A5045731423 @default.
• W3210136110 hasAuthorship W3210136110A5053501729 @default.
• W3210136110 hasAuthorship W3210136110A5059082232 @default.
• W3210136110 hasAuthorship W3210136110A5062342454 @default.
• W3210136110 hasAuthorship W3210136110A5062748816 @default.
• W3210136110 hasAuthorship W3210136110A5070464513 @default.
• W3210136110 hasAuthorship W3210136110A5083101716 @default.
• W3210136110 hasConcept C126322002 @default.
• W3210136110 hasConcept C126838900 @default.
• W3210136110 hasConcept C143998085 @default.
• W3210136110 hasConcept C146357865 @default.
• W3210136110 hasConcept C151730666 @default.
• W3210136110 hasConcept C167135981 @default.
• W3210136110 hasConcept C2777058707 @default.
• W3210136110 hasConcept C2777910003 @default.
• W3210136110 hasConcept C2779338263 @default.
• W3210136110 hasConcept C509974204 @default.
• W3210136110 hasConcept C71924100 @default.
• W3210136110 hasConcept C86803240 @default.
• W3210136110 hasConceptScore W3210136110C126322002 @default.
• W3210136110 hasConceptScore W3210136110C126838900 @default.
• W3210136110 hasConceptScore W3210136110C143998085 @default.
• W3210136110 hasConceptScore W3210136110C146357865 @default.
• W3210136110 hasConceptScore W3210136110C151730666 @default.
• W3210136110 hasConceptScore W3210136110C167135981 @default.
• W3210136110 hasConceptScore W3210136110C2777058707 @default.
• W3210136110 hasConceptScore W3210136110C2777910003 @default.
• W3210136110 hasConceptScore W3210136110C2779338263 @default.
• W3210136110 hasConceptScore W3210136110C509974204 @default.
• W3210136110 hasConceptScore W3210136110C71924100 @default.
• W3210136110 hasConceptScore W3210136110C86803240 @default.
• W3210136110 hasIssue "3" @default.
• W3210136110 hasLocation W32101361101 @default.
• W3210136110 hasLocation W32101361102 @default.
• W3210136110 hasOpenAccess W3210136110 @default.
• W3210136110 hasPrimaryLocation W32101361101 @default.
• W3210136110 hasRelatedWork W2006668081 @default.
• W3210136110 hasRelatedWork W2050662773 @default.
• W3210136110 hasRelatedWork W2057721052 @default.
• W3210136110 hasRelatedWork W2074838061 @default.
• W3210136110 hasRelatedWork W2116001782 @default.
• W3210136110 hasRelatedWork W2411455308 @default.
• W3210136110 hasRelatedWork W2411610896 @default.
• W3210136110 hasRelatedWork W4220939315 @default.
• W3210136110 hasRelatedWork W4224870306 @default.
• W3210136110 hasRelatedWork W4291189777 @default.
• W3210136110 hasVolume "111" @default.
• W3210136110 isParatext "false" @default.
• W3210136110 isRetracted "false" @default.
• W3210136110 magId "3210136110" @default.
• W3210136110 workType "article" @default.