Matches in SemOpenAlex for { <https://semopenalex.org/work/W3210137428> ?p ?o ?g. }
Showing items 1 to 85 of
85
with 100 items per page.
- W3210137428 endingPage "S55" @default.
- W3210137428 startingPage "S55" @default.
- W3210137428 abstract "Abstract Introduction/Objective Patients with microsatellite instability (MSI) are susceptible to developing epithelial malignancies in multiple organs and systems, especially along the gastrointestinal tract. It’s important to know that MSI-tumors may present with an intriguing non-classical, “non-MSI-appearing”, histomorphology that deviates from the well-known MSI or Lynch syndrome spectrum. Pathologists should thus be prepared for unusual histopathological presentations in order to detect MSI and related therapeutic and prognostic targets. Ultimately, a timely and accurate classification is a crucial step in guiding clinical course. Methods/Case Report An 80-year-old male presented to an outside facility due to worsening dysphagia. Imaging and endoscopy studies confirmed a near-obstructing distal esophageal mass. Subsequently, an esophagogastrostomy was performed, which removed a moderately differentiated adenocarcinoma (pT3N1). The patient was managed with conventional chemotherapy after the surgery; however, due to progressive metastasis involving the liver, he was referred to our cancer center. Results (if a Case Study enter NA) Upon review of outside pathology materials, the tumor displayed irregularly arranged bizarre glands with eosinophilic cytoplasm and unusually large nuclei within the abundant fibrotic stroma. No intra-tumoral lymphocytes or “Crohn’s-like” pushing borders were identified. However, ancillary tests performed on acquired outside material showed loss of MLH1 and PMS2 with retained MSH2 and MSH6 in the tumor. Subsequent mutational analysis revealed additional MSI-related carcinogenic mutations. Accordingly, the previous regimen was switched to immunotherapy-based management. The patient remains disease-free 10-months later. Conclusion This unusual MSI esophageal adenocarcinoma exemplifies that such tumors may present with non- MSI/non-lynch histomorphology and that ancillary analyses should be carried out without reservation to evaluate microsatellite status. Thus, optimizing patient management and outcome." @default.
- W3210137428 created "2021-11-08" @default.
- W3210137428 creator A5009954908 @default.
- W3210137428 creator A5056295842 @default.
- W3210137428 creator A5056398068 @default.
- W3210137428 date "2021-10-01" @default.
- W3210137428 modified "2023-09-24" @default.
- W3210137428 title "Microsatellite unstable esophageal adenocarcinoma masquerading as a conventional esophageal primary" @default.
- W3210137428 doi "https://doi.org/10.1093/ajcp/aqab191.112" @default.
- W3210137428 hasPublicationYear "2021" @default.
- W3210137428 type Work @default.
- W3210137428 sameAs 3210137428 @default.
- W3210137428 citedByCount "0" @default.
- W3210137428 crossrefType "journal-article" @default.
- W3210137428 hasAuthorship W3210137428A5009954908 @default.
- W3210137428 hasAuthorship W3210137428A5056295842 @default.
- W3210137428 hasAuthorship W3210137428A5056398068 @default.
- W3210137428 hasBestOaLocation W32101374281 @default.
- W3210137428 hasConcept C104317684 @default.
- W3210137428 hasConcept C111425858 @default.
- W3210137428 hasConcept C121608353 @default.
- W3210137428 hasConcept C126322002 @default.
- W3210137428 hasConcept C126838900 @default.
- W3210137428 hasConcept C142724271 @default.
- W3210137428 hasConcept C143998085 @default.
- W3210137428 hasConcept C180754005 @default.
- W3210137428 hasConcept C2776559941 @default.
- W3210137428 hasConcept C2776674815 @default.
- W3210137428 hasConcept C2777819096 @default.
- W3210137428 hasConcept C2779013556 @default.
- W3210137428 hasConcept C2779115348 @default.
- W3210137428 hasConcept C2779742542 @default.
- W3210137428 hasConcept C2779767149 @default.
- W3210137428 hasConcept C2780596822 @default.
- W3210137428 hasConcept C2781182431 @default.
- W3210137428 hasConcept C526805850 @default.
- W3210137428 hasConcept C55493867 @default.
- W3210137428 hasConcept C60748783 @default.
- W3210137428 hasConcept C61320498 @default.
- W3210137428 hasConcept C71924100 @default.
- W3210137428 hasConcept C86803240 @default.
- W3210137428 hasConceptScore W3210137428C104317684 @default.
- W3210137428 hasConceptScore W3210137428C111425858 @default.
- W3210137428 hasConceptScore W3210137428C121608353 @default.
- W3210137428 hasConceptScore W3210137428C126322002 @default.
- W3210137428 hasConceptScore W3210137428C126838900 @default.
- W3210137428 hasConceptScore W3210137428C142724271 @default.
- W3210137428 hasConceptScore W3210137428C143998085 @default.
- W3210137428 hasConceptScore W3210137428C180754005 @default.
- W3210137428 hasConceptScore W3210137428C2776559941 @default.
- W3210137428 hasConceptScore W3210137428C2776674815 @default.
- W3210137428 hasConceptScore W3210137428C2777819096 @default.
- W3210137428 hasConceptScore W3210137428C2779013556 @default.
- W3210137428 hasConceptScore W3210137428C2779115348 @default.
- W3210137428 hasConceptScore W3210137428C2779742542 @default.
- W3210137428 hasConceptScore W3210137428C2779767149 @default.
- W3210137428 hasConceptScore W3210137428C2780596822 @default.
- W3210137428 hasConceptScore W3210137428C2781182431 @default.
- W3210137428 hasConceptScore W3210137428C526805850 @default.
- W3210137428 hasConceptScore W3210137428C55493867 @default.
- W3210137428 hasConceptScore W3210137428C60748783 @default.
- W3210137428 hasConceptScore W3210137428C61320498 @default.
- W3210137428 hasConceptScore W3210137428C71924100 @default.
- W3210137428 hasConceptScore W3210137428C86803240 @default.
- W3210137428 hasIssue "Supplement_1" @default.
- W3210137428 hasLocation W32101374281 @default.
- W3210137428 hasOpenAccess W3210137428 @default.
- W3210137428 hasPrimaryLocation W32101374281 @default.
- W3210137428 hasRelatedWork W1509212822 @default.
- W3210137428 hasRelatedWork W1984307543 @default.
- W3210137428 hasRelatedWork W2015881451 @default.
- W3210137428 hasRelatedWork W2100442244 @default.
- W3210137428 hasRelatedWork W2584140133 @default.
- W3210137428 hasRelatedWork W2898571352 @default.
- W3210137428 hasRelatedWork W3011378427 @default.
- W3210137428 hasRelatedWork W4298148436 @default.
- W3210137428 hasRelatedWork W2186066481 @default.
- W3210137428 hasRelatedWork W2413541173 @default.
- W3210137428 hasVolume "156" @default.
- W3210137428 isParatext "false" @default.
- W3210137428 isRetracted "false" @default.
- W3210137428 magId "3210137428" @default.
- W3210137428 workType "article" @default.