Matches in SemOpenAlex for { <https://semopenalex.org/work/W3210149807> ?p ?o ?g. }
- W3210149807 endingPage "e1009889" @default.
- W3210149807 startingPage "e1009889" @default.
- W3210149807 abstract "Beyond their canonical function in nucleocytoplasmic exchanges, nuclear pore complexes (NPCs) regulate the expression of protein-coding genes. Here, we have implemented transcriptomic and molecular methods to specifically address the impact of the NPC on retroelements, which are present in multiple copies in genomes. We report a novel function for the Nup84 complex, a core NPC building block, in specifically restricting the transcription of LTR-retrotransposons in yeast. Nup84 complex-dependent repression impacts both Copia and Gypsy Ty LTR-retrotransposons, all over the S . cerevisiae genome. Mechanistically, the Nup84 complex restricts the transcription of Ty1, the most active yeast retrotransposon, through the tethering of the SUMO-deconjugating enzyme Ulp1 to NPCs. Strikingly, the modest accumulation of Ty1 RNAs caused by Nup84 complex loss-of-function is sufficient to trigger an important increase of Ty1 cDNA levels, resulting in massive Ty1 retrotransposition. Altogether, our study expands our understanding of the complex interactions between retrotransposons and the NPC, and highlights the importance for the cells to keep retrotransposons under tight transcriptional control." @default.
- W3210149807 created "2021-11-08" @default.
- W3210149807 creator A5016315152 @default.
- W3210149807 creator A5019811686 @default.
- W3210149807 creator A5020446024 @default.
- W3210149807 creator A5052972676 @default.
- W3210149807 creator A5075914132 @default.
- W3210149807 date "2021-11-01" @default.
- W3210149807 modified "2023-09-30" @default.
- W3210149807 title "A nuclear pore sub-complex restricts the propagation of Ty retrotransposons by limiting their transcription" @default.
- W3210149807 cites W1921052768 @default.
- W3210149807 cites W1926028962 @default.
- W3210149807 cites W1936611779 @default.
- W3210149807 cites W1963504189 @default.
- W3210149807 cites W1978895170 @default.
- W3210149807 cites W1981329233 @default.
- W3210149807 cites W1981866732 @default.
- W3210149807 cites W1982741055 @default.
- W3210149807 cites W1984945120 @default.
- W3210149807 cites W1987156564 @default.
- W3210149807 cites W1988923344 @default.
- W3210149807 cites W1994598776 @default.
- W3210149807 cites W1999227561 @default.
- W3210149807 cites W2002538481 @default.
- W3210149807 cites W2005205256 @default.
- W3210149807 cites W2011007445 @default.
- W3210149807 cites W2013584797 @default.
- W3210149807 cites W2013706075 @default.
- W3210149807 cites W2019654388 @default.
- W3210149807 cites W2019923915 @default.
- W3210149807 cites W2024567907 @default.
- W3210149807 cites W2024578708 @default.
- W3210149807 cites W2043249063 @default.
- W3210149807 cites W2043644121 @default.
- W3210149807 cites W2045862142 @default.
- W3210149807 cites W2052586663 @default.
- W3210149807 cites W2054555589 @default.
- W3210149807 cites W2055764576 @default.
- W3210149807 cites W2057968668 @default.
- W3210149807 cites W2058402081 @default.
- W3210149807 cites W2063490358 @default.
- W3210149807 cites W2063587388 @default.
- W3210149807 cites W2072876216 @default.
- W3210149807 cites W2074541523 @default.
- W3210149807 cites W2085304899 @default.
- W3210149807 cites W2091642705 @default.
- W3210149807 cites W2091997786 @default.
- W3210149807 cites W2092952480 @default.
- W3210149807 cites W2097647525 @default.
- W3210149807 cites W2097982583 @default.
- W3210149807 cites W2100045646 @default.
- W3210149807 cites W2100459042 @default.
- W3210149807 cites W2101107183 @default.
- W3210149807 cites W2102278945 @default.
- W3210149807 cites W2102619694 @default.
- W3210149807 cites W2108234281 @default.
- W3210149807 cites W2109845157 @default.
- W3210149807 cites W2110303147 @default.
- W3210149807 cites W2114875490 @default.
- W3210149807 cites W2116114189 @default.
- W3210149807 cites W2117403595 @default.
- W3210149807 cites W2122713795 @default.
- W3210149807 cites W2130024434 @default.
- W3210149807 cites W2131150601 @default.
- W3210149807 cites W2131271579 @default.
- W3210149807 cites W2132665479 @default.
- W3210149807 cites W2135144130 @default.
- W3210149807 cites W2136949260 @default.
- W3210149807 cites W2138207763 @default.
- W3210149807 cites W2142896923 @default.
- W3210149807 cites W2142976581 @default.
- W3210149807 cites W2144887544 @default.
- W3210149807 cites W2146614388 @default.
- W3210149807 cites W2146666887 @default.
- W3210149807 cites W2152573239 @default.
- W3210149807 cites W2153606842 @default.
- W3210149807 cites W2154583738 @default.
- W3210149807 cites W2154805387 @default.
- W3210149807 cites W2156500567 @default.
- W3210149807 cites W2162828523 @default.
- W3210149807 cites W2166077200 @default.
- W3210149807 cites W2168143468 @default.
- W3210149807 cites W2170863549 @default.
- W3210149807 cites W2179438025 @default.
- W3210149807 cites W2191182742 @default.
- W3210149807 cites W2323295555 @default.
- W3210149807 cites W2339328439 @default.
- W3210149807 cites W2341539131 @default.
- W3210149807 cites W2516620605 @default.
- W3210149807 cites W2547035613 @default.
- W3210149807 cites W2560753267 @default.
- W3210149807 cites W2564335181 @default.
- W3210149807 cites W2741326531 @default.
- W3210149807 cites W2752724466 @default.
- W3210149807 cites W2754076530 @default.
- W3210149807 cites W2766958871 @default.
- W3210149807 cites W2767008202 @default.
- W3210149807 cites W2789110439 @default.