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- W3210170852 endingPage "2862" @default.
- W3210170852 startingPage "2862" @default.
- W3210170852 abstract "Cancer cells can reprogram their metabolic activities and undergo uncontrolled proliferation by utilizing the power of heat shock proteins (HSPs). HSPs are highly conserved chaperones that facilitate the folding of intracellular proteins under stress. Constitutively, HSPs are expressed at low levels, but their expression upregulates in response to a wide variety of insults, including anticancer drugs, allowing cancer cells to develop chemoresistance. In recent years, several researchers have reported that HSPs could be an important therapeutic target in difficult-to-treat cancers such as colorectal carcinoma (CRC). Worldwide, CRC is the second most common type of cancer and the second leading cause of cancer-related deaths. The molecular complexity of CRC and the coexisting inflammatory conditions present a significant obstacle to developing effective treatment. Recently, considerable progress has been made in enhancing our understanding of the role of HSPs in CRC pathogenesis. Moreover, novel therapeutic strategies targeting HSPs, either alone or in combination with other anticancer agents, have been reported. Herein, we present an overview of the functional mechanisms and the diagnostic and prognostic potential of HSPs in CRC. We also discuss emerging anti-CRC strategies based on targeting HSPs." @default.
- W3210170852 created "2021-11-08" @default.
- W3210170852 creator A5001733179 @default.
- W3210170852 creator A5060258160 @default.
- W3210170852 creator A5068769091 @default.
- W3210170852 creator A5073394160 @default.
- W3210170852 date "2021-10-24" @default.
- W3210170852 modified "2023-10-16" @default.
- W3210170852 title "Ins and Outs of Heat Shock Proteins in Colorectal Carcinoma: Its Role in Carcinogenesis and Therapeutic Perspectives" @default.
- W3210170852 cites W1501101425 @default.
- W3210170852 cites W1502349162 @default.
- W3210170852 cites W1526728179 @default.
- W3210170852 cites W1808605164 @default.
- W3210170852 cites W1920856529 @default.
- W3210170852 cites W1966492828 @default.
- W3210170852 cites W1969853607 @default.
- W3210170852 cites W1970784499 @default.
- W3210170852 cites W1972110853 @default.
- W3210170852 cites W1978325418 @default.
- W3210170852 cites W1990389298 @default.
- W3210170852 cites W1998886634 @default.
- W3210170852 cites W1999824570 @default.
- W3210170852 cites W2003791117 @default.
- W3210170852 cites W2014576328 @default.
- W3210170852 cites W2017229007 @default.
- W3210170852 cites W2027069379 @default.
- W3210170852 cites W2028705478 @default.
- W3210170852 cites W2028971520 @default.
- W3210170852 cites W2033106731 @default.
- W3210170852 cites W2038261675 @default.
- W3210170852 cites W2044204464 @default.
- W3210170852 cites W2048978941 @default.
- W3210170852 cites W2075188892 @default.
- W3210170852 cites W2077427662 @default.
- W3210170852 cites W2080800396 @default.
- W3210170852 cites W2082961519 @default.
- W3210170852 cites W2093872436 @default.
- W3210170852 cites W2103373547 @default.
- W3210170852 cites W2109936231 @default.
- W3210170852 cites W2117288359 @default.
- W3210170852 cites W2123520511 @default.
- W3210170852 cites W2131271517 @default.
- W3210170852 cites W2132968032 @default.
- W3210170852 cites W2181262244 @default.
- W3210170852 cites W2252295447 @default.
- W3210170852 cites W2270834283 @default.
- W3210170852 cites W2342335890 @default.
- W3210170852 cites W2343430675 @default.
- W3210170852 cites W2346154457 @default.
- W3210170852 cites W2402610460 @default.
- W3210170852 cites W2478037884 @default.
- W3210170852 cites W2502404460 @default.
- W3210170852 cites W2515585752 @default.
- W3210170852 cites W2551088026 @default.
- W3210170852 cites W2559835914 @default.
- W3210170852 cites W2566859523 @default.
- W3210170852 cites W2577465983 @default.
- W3210170852 cites W2585032307 @default.
- W3210170852 cites W2609558343 @default.
- W3210170852 cites W2631413551 @default.
- W3210170852 cites W2699348072 @default.
- W3210170852 cites W2755428803 @default.
- W3210170852 cites W2780463052 @default.
- W3210170852 cites W2783598097 @default.
- W3210170852 cites W2788709098 @default.
- W3210170852 cites W2799662254 @default.
- W3210170852 cites W2800229102 @default.
- W3210170852 cites W2884578107 @default.
- W3210170852 cites W2886372396 @default.
- W3210170852 cites W2887739857 @default.
- W3210170852 cites W2891141728 @default.
- W3210170852 cites W2894798439 @default.
- W3210170852 cites W2901909497 @default.
- W3210170852 cites W2904049988 @default.
- W3210170852 cites W2904077352 @default.
- W3210170852 cites W2905545423 @default.
- W3210170852 cites W2914236451 @default.
- W3210170852 cites W2920001469 @default.
- W3210170852 cites W2920910005 @default.
- W3210170852 cites W2944120773 @default.
- W3210170852 cites W2945170725 @default.
- W3210170852 cites W2946215758 @default.
- W3210170852 cites W2951782366 @default.
- W3210170852 cites W2965628604 @default.
- W3210170852 cites W2969864766 @default.
- W3210170852 cites W2971557207 @default.
- W3210170852 cites W2972657579 @default.
- W3210170852 cites W2974325953 @default.
- W3210170852 cites W2974909977 @default.
- W3210170852 cites W2977122965 @default.
- W3210170852 cites W2980500079 @default.
- W3210170852 cites W2981675923 @default.
- W3210170852 cites W2982659210 @default.
- W3210170852 cites W2983955174 @default.
- W3210170852 cites W2988980269 @default.
- W3210170852 cites W2997805606 @default.
- W3210170852 cites W2999201878 @default.
- W3210170852 cites W2999779055 @default.