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• W3210190970 abstract "Myo-inositol is a precursor of the membrane phospholipid, phosphatidylinositol (PI). It is involved in many essential cellular processes including signal transduction, energy metabolism, endoplasmic reticulum stress, and osmoregulation. Inositol is synthesized from glucose-6-phosphate by myo-inositol-3-phosphate synthase (MIPSp). The Drosophila melanogaster Inos gene encodes MIPSp. Abnormalities in myo-inositol metabolism have been implicated in type 2 diabetes, cancer, and neurodegenerative disorders. Obesity and high blood (hemolymph) glucose are two hallmarks of diabetes, which can be induced in Drosophila melanogaster third-instar larvae by high-sucrose diets. This study shows that dietary inositol reduces the obese-like and high-hemolymph glucose phenotypes of third-instar larvae fed high-sucrose diets. Furthermore, this study demonstrates Inos mRNA regulation by dietary inositol; when more inositol is provided there is less Inos mRNA. Third-instar larvae with dysregulated high levels of Inos mRNA and MIPSp show dramatic reductions of the obese-like and high-hemolymph glucose phenotypes. These strains, however, also display developmental defects and pupal lethality. The few individuals that eclose die within two days with striking defects: structural alterations of the wings and legs, and heads lacking proboscises. This study is an exciting extension of the use of Drosophila melanogaster as a model organism for exploring the junction of development and metabolism." @default.
• W3210190970 created "2021-11-08" @default.
• W3210190970 creator A5000768349 @default.
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• W3210190970 creator A5065040547 @default.
• W3210190970 date "2021-10-15" @default.
• W3210190970 modified "2023-09-26" @default.
• W3210190970 title "Regulated inositol synthesis is critical for balanced metabolism and development in <i>Drosophila melanogaster</i>" @default.
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• W3210190970 doi "https://doi.org/10.1242/bio.058833" @default.
• W3210190970 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8565467" @default.
• W3210190970 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34710213" @default.
• W3210190970 hasPublicationYear "2021" @default.
• W3210190970 type Work @default.
• W3210190970 sameAs 3210190970 @default.

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