FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3210196688> ?p ?o ?g. }

• W3210196688 endingPage "795" @default.
• W3210196688 startingPage "790" @default.
• W3210196688 abstract "Type 1 diabetes (T1D) is a chronic autoimmune disease of childhood affecting 1:500 children aged under 15 years, with around 25% presenting with life-threatening diabetic ketoacidosis (DKA). While first-degree relatives have the highest risk of T1D, more than 85% of children who develop T1D do not have a family history. Despite public health awareness campaigns, DKA rates have not fallen over the last decade. T1D has a long prodrome, and it is now possible to identify children who go on to develop T1D with a high degree of certainty. The reasons for identifying children presymptomatically include prevention of DKA and related morbidities and mortality, reducing the need for hospitalisation, time to provide emotional support and education to ensure a smooth transition to insulin treatment, and opportunities for new treatments to prevent or delay progression. Research studies of population-based screening strategies include using islet autoantibodies alone or in combination with genetic risk factors, both of which can be measured from a capillary sample. If found during screening, the presence of two or more islet autoantibodies has a high positive predictive value for future T1D in childhood (under 18 years), offering an opportunity for DKA prevention. However, a single time-point test will not identify all children who go on to develop T1D, and so combining with genetic risk factors for T1D may be an alternative approach. Here we discuss the pros and cons of T1D screening in the UK, the different strategies available, the knowledge gaps and why a T1D screening strategy is needed." @default.
• W3210196688 created "2021-11-08" @default.
• W3210196688 creator A5029984659 @default.
• W3210196688 creator A5032123532 @default.
• W3210196688 creator A5063960889 @default.
• W3210196688 creator A5068658241 @default.
• W3210196688 creator A5069129983 @default.
• W3210196688 creator A5078314492 @default.
• W3210196688 date "2021-11-05" @default.
• W3210196688 modified "2023-09-26" @default.
• W3210196688 title "General population screening for childhood type 1 diabetes: is it time for a UK strategy?" @default.
• W3210196688 cites W1925140590 @default.
• W3210196688 cites W1942296996 @default.
• W3210196688 cites W2032070373 @default.
• W3210196688 cites W2043114954 @default.
• W3210196688 cites W2049204060 @default.
• W3210196688 cites W2051883261 @default.
• W3210196688 cites W2095256598 @default.
• W3210196688 cites W2095285670 @default.
• W3210196688 cites W2098825592 @default.
• W3210196688 cites W2130601108 @default.
• W3210196688 cites W2145691772 @default.
• W3210196688 cites W2147602249 @default.
• W3210196688 cites W2326904657 @default.
• W3210196688 cites W2594850664 @default.
• W3210196688 cites W2739470548 @default.
• W3210196688 cites W2740851732 @default.
• W3210196688 cites W2789802001 @default.
• W3210196688 cites W2807718461 @default.
• W3210196688 cites W2885611015 @default.
• W3210196688 cites W2904932351 @default.
• W3210196688 cites W2909847496 @default.
• W3210196688 cites W2912769950 @default.
• W3210196688 cites W2939526051 @default.
• W3210196688 cites W2948104235 @default.
• W3210196688 cites W2949088599 @default.
• W3210196688 cites W3003622489 @default.
• W3210196688 cites W3018568543 @default.
• W3210196688 cites W3023814294 @default.
• W3210196688 cites W3048014252 @default.
• W3210196688 cites W3080368399 @default.
• W3210196688 cites W3088208944 @default.
• W3210196688 cites W3097352840 @default.
• W3210196688 cites W3133375349 @default.
• W3210196688 cites W3142901137 @default.
• W3210196688 cites W3163112646 @default.
• W3210196688 cites W979034263 @default.
• W3210196688 doi "https://doi.org/10.1136/archdischild-2021-321864" @default.
• W3210196688 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34740879" @default.
• W3210196688 hasPublicationYear "2021" @default.
• W3210196688 type Work @default.
• W3210196688 sameAs 3210196688 @default.
• W3210196688 citedByCount "4" @default.
• W3210196688 countsByYear W32101966882022 @default.
• W3210196688 countsByYear W32101966882023 @default.
• W3210196688 crossrefType "journal-article" @default.
• W3210196688 hasAuthorship W3210196688A5029984659 @default.
• W3210196688 hasAuthorship W3210196688A5032123532 @default.
• W3210196688 hasAuthorship W3210196688A5063960889 @default.
• W3210196688 hasAuthorship W3210196688A5068658241 @default.
• W3210196688 hasAuthorship W3210196688A5069129983 @default.
• W3210196688 hasAuthorship W3210196688A5078314492 @default.
• W3210196688 hasConcept C118552586 @default.
• W3210196688 hasConcept C126322002 @default.
• W3210196688 hasConcept C134018914 @default.
• W3210196688 hasConcept C187212893 @default.
• W3210196688 hasConcept C2779134260 @default.
• W3210196688 hasConcept C2779727114 @default.
• W3210196688 hasConcept C2780292510 @default.
• W3210196688 hasConcept C2781232474 @default.
• W3210196688 hasConcept C2781283889 @default.
• W3210196688 hasConcept C2908647359 @default.
• W3210196688 hasConcept C512399662 @default.
• W3210196688 hasConcept C555293320 @default.
• W3210196688 hasConcept C71924100 @default.
• W3210196688 hasConcept C99454951 @default.
• W3210196688 hasConceptScore W3210196688C118552586 @default.
• W3210196688 hasConceptScore W3210196688C126322002 @default.
• W3210196688 hasConceptScore W3210196688C134018914 @default.
• W3210196688 hasConceptScore W3210196688C187212893 @default.
• W3210196688 hasConceptScore W3210196688C2779134260 @default.
• W3210196688 hasConceptScore W3210196688C2779727114 @default.
• W3210196688 hasConceptScore W3210196688C2780292510 @default.
• W3210196688 hasConceptScore W3210196688C2781232474 @default.
• W3210196688 hasConceptScore W3210196688C2781283889 @default.
• W3210196688 hasConceptScore W3210196688C2908647359 @default.
• W3210196688 hasConceptScore W3210196688C512399662 @default.
• W3210196688 hasConceptScore W3210196688C555293320 @default.
• W3210196688 hasConceptScore W3210196688C71924100 @default.
• W3210196688 hasConceptScore W3210196688C99454951 @default.
• W3210196688 hasFunder F4320307874 @default.
• W3210196688 hasFunder F4320310820 @default.
• W3210196688 hasIssue "9" @default.
• W3210196688 hasLocation W32101966881 @default.
• W3210196688 hasLocation W32101966882 @default.
• W3210196688 hasOpenAccess W3210196688 @default.
• W3210196688 hasPrimaryLocation W32101966881 @default.
• W3210196688 hasRelatedWork W2000571139 @default.

• next